Su Hyun (Sue) Lee

Postdoc in the @theaglab interested in drug resistance, and protein degradation in cancer

Ph.D. in @SeoulNatlUni | Protein degradation, selective autophagy

[gerry melino @melino_G]

Session 1: Aaron CIECHANOVER, Ivan DIKIC, Wei JIA, Michele CARBONE. THE CANCER CHALLENGE....
Free participation
https://t.co/z56RJi6dWW
September 19th, at 10:00 AM

[Katherine A Donovan @kdonovan1008]

We have exciting new updates to our schedule for the free TPD in-person event on September 14th!
Register on our webpage and see you soon!!

[Hojong Yoon @hojong_yoon]

Registration for our 2nd in-person meeting is now open, featuring fantastic programs lined up!

We're also hosting 5-min flask talks, so if you're interested, please submit your abstract!

Registration: https://t.co/3UHVTnNdgE

[Su Hyun (Sue) Lee @SH_LEE_528]

@The_Will_Lab @FASEBorg It was an awesome time! Thank you for organizing :)

[Su Hyun (Sue) Lee @SH_LEE_528]

@PhD_Cream @Doulatov_lab @GalvisBaquero Nice to see you and see you next FASEB!

[Britta Will @The_Will_Lab]

Many, many thanks to @FASEBorg, our various sponsors, and the BEST CONFERENCE TAC TEAM one could wish for (from left):
Su Hyun Lee & Juliane Grimm (#HMSRC acellerators), Liam Mulholland (AV wizzard).

[Su Hyun (Sue) Lee @SH_LEE_528]

@CastilloQuan_JI @JoslinDiabetes @harvardmed wow are you in Joslin Diabetes? I am in BCH! 🫡

[Hojong Yoon @hojong_yoon]

This example highlights that just inducing proximity between two proteins is not enough to trigger degradation; crossing the threshold is necessary for effective translation of induced proximity into degradation, and medchem effort did its job!

[Mizushima Lab (UTokyo) @MizLabUT]

Our new paper is out in @MolecularCell !! We found phosphatidylethanolamine is ubiquitinated!! Congratulatioons Jun-ichi!!
https://t.co/xFiDJHT1qr

[Hojong Yoon @hojong_yoon]

A tour de force from @mike_tilapia on functional assessment of UPS machinery for TPD or TPS.

Interesting to see that there is a huge difference in the activity of E3s (or E2s), I always wonder where this difference comes from, if it's just based on proximity.

[Mizushima Lab (UTokyo) @MizLabUT]

Monitor autophagic flux in mammalian cells easily with our new method, now out in @eLife! Pulse-labeled HaloTag reporters are processed in lysosomes, releasing proteolysis-resistant labeled Halo. Free labeled Halo amount = autophagic flux! →western/in-gel fluo/microsc./flow cyto

[Dan Gibbs @DJ_Gibbs]

New @TrendsCellBio review on roles for the Cys/N-degron pathway in ubiquitin-proteasome mediated degradation and autophagy 🐁🌱https://t.co/9SFhOnX6Yp

[Johannes Herrmann @Herrmann_lab]

We made a surprising discovery: the yeast cytosol can store mitochondrial precursor proteins in dedicated granules which we named MitoStores. MitoStores are controlled by the chaperone network and protect cells against mitoprotein-induced stress. https://t.co/FpFJPLIeHC

[Su Hyun (Sue) Lee @SH_LEE_528]

@JeeyunC @MCB_Harvard Congratulations!👍

[Mitochondrial Medicine @Mito_Therapy]

Happy to share our latest review on "Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective".
Thanks to @BottaniEmanuela @iva_dime @DrGiuliaMassaro, Alessia Di Donfrancesco and Valeria Tiranti for their contribution

https://t.co/BTtsAsB1vW

[Su Hyun (Sue) Lee @SH_LEE_528]

@whoisyoo You are really awsome!!!

[Su Hyun (Sue) Lee @SH_LEE_528]

@whoisyoo @STARProtocols congratulations!🎉

[Dougan Lab @DouganLab]

A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC https://t.co/0HJoeT2RUj

[Su Hyun (Sue) Lee @SH_LEE_528]

Check out the weekly collection of papers on #autophagy, #disease, and #therapeutic strategy.
@BiomedNew recommended interesting and insightful papers! Thanks
https://t.co/a4N9xQW44K

[Su Hyun (Sue) Lee @SH_LEE_528]

@DJ_Gibbs @EMBO How time flies! 🇩🇪🇰🇷🇳🇴