SNR

Make America Great Again
BIG IDEA! SIMPLE EXPERIMENTS!

[SNR @shiv_RNA]

“You could say what we’ve learned so far is what the complex looks like, and we’ve also learned how it’s built.”

Not a bad start.

[Wisdom Stoics @WisdomStoics]

Real talk.

[Reads with Ravi @readswithravi]

Focus on consistency, not intensity. Progress comes from showing up daily.

[The Nobel Prize @NobelPrize]

"I slept and dreamt that life was joy. I awoke and saw that life was service. I acted and behold, service was joy."

Literature laureate Rabindranath Tagore dedicated his life to poetry, art and music, composing the Indian national anthem and the national anthem of Bangladesh.

[The Nobel Prize @NobelPrize]

We're celebrating the 165th anniversary of the birth of a true great: Rabindranath Tagore, who was born #onthisday 7 May, in 1861 in Calcutta, India.

The first non-European literature laureate, he was awarded the #NobelPrize "because of his profoundly sensitive, fresh and beautiful verse, by which, with consummate skill, he has made his poetic thought, expressed in his own English words, a part of the literature of the West."

Read more: https://t.co/cglURuTyvy

#Tagore165

[SNR @shiv_RNA]

Check out my latest creation on Emergent! https://t.co/1vxbaAT1XL

I'm using Emergent to bring my ideas to life. Join me and 1.5M+ builders: https://t.co/RO8LopaJbn

[The Knowledge Archivist @KnowledgeArchiv]

“The biggest mistake we make in life is thinking we have time”

―Kobe Bryant

[Nature Biotechnology @NatureBiotech]

An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery https://t.co/AweqzQSXjq

[William A. Wallace, Ph.D. @WilliamWallace]

Mitochondria coordinate far more than ATP.

🔻 Cytochrome c → apoptosis
🔷 H₂O₂ → redox + protein thiol signaling
🔴 NADH/NAD⁺ → integrated stress response
🔺 AMPK → metabolic/catabolic shift
🧬 mtDNA/mtRNA → innate immune activation
💠 TCA metabolites → chromatin + cell-fate programming

[Cancer Cell @Cancer_Cell]

Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications https://t.co/JLbGgHTT5Z

[nature @Nature]

Cancer cells use mitochondria stolen from immune cells to spread and escape detection

https://t.co/dPJ4TMqI9b

[Molecular Cell @MolecularCell]

Online Now: Epigenetic consequences of DNA damage https://t.co/Qt2fEsxYwB

[Sounak Sahu @SounakSahu]

✨ New Year, New Lab, New Beginnings ✨ Join us in New York as we are building our team. We are interested in understanding the molecular and cellular mechanisms underlying human breast development, tissue homeostasis, and breast cancer. https://t.co/FtKE9C7Z6i Please RT.

[William A. Wallace, Ph.D. @WilliamWallace]

Mitochondria are not just power plants.
They are decision-makers.
They regulate inflammation, aging, and disease.

A quick breakdown:

🔵 Energy signaling, not just energy production
Mitochondria don’t just make energy.
They decide how energy is produced, where it’s used, and when cells change their behavior.
Energy itself acts as a signal that tells cells what to do.

🟣 Inflammation control
When mitochondria are damaged, they release internal components into the cell.
The immune system interprets these as danger signals and turns inflammation on, even without infection.

🟡 Aging regulation
As we age, cells become worse at clearing damaged mitochondria.
These dysfunctional mitochondria build up, increasing oxidative damage and low-grade inflammation that drives aging.

🟢 Why many diseases look different but share the same root
Neurodegenerative disease, heart disease, diabetes, obesity, autoimmune disease, sepsis, and cancer all involve failure of mitochondrial function.
Different organs. Same underlying problem.

🟠 Why “antioxidants” alone miss the point
The problem isn’t just damage.
It’s where the damage happens, why it happens, and whether the cell can remove the broken machinery afterward.

🔴 Why this changes how we think about health
You don’t treat dozens of unrelated diseases separately.
You support mitochondrial health—and multiple systems improve together.

What this all means:
• Mitochondria are control centers, not batteries
• Inflammation often starts as an energy problem
• Aging reflects declining cellular maintenance
• Many diseases are the same biology showing up in different tissues

Health isn’t just chemistry.
It’s how cells manage energy.
And mitochondria sit at the center of the system.

Doi:10.1038/s41392-025-02253-4