Jingliang Simon Zhang

Neuroscience | Poetry | Cinema | Game |
Life Science @PKU1898 ➡️ DevBio @HopkinsCMDB

[Jingliang Simon Zhang @simonational]

Huge shout-out to my co-authors (@csanti412, @YaWenChenMSSM, Seth, @BobbyJEyeGuy, and Twitter-less others) for their support in this work! Thanks for reading to the end of this thread😆 Excited to discuss and explore what’s next in the field! ✨✨ (8/8)

[Jingliang Simon Zhang @simonational]

Excited to see my PhD work is now published @CellReports! In this study, we used human retinal organoids to investigate how cell death occurs and affects the development and survival of retinal ganglion cells (RGCs), the projection neurons in the eye (1/8) https://t.co/pC28z4vKWY

[Jingliang Simon Zhang @simonational]

Further analysis shows blocking apoptosis does not extend the RGC generation window, but slows early neurogenesis and maturation. It also prolongs RGC lifespan and improves mature RGC survival in organoids, exhibiting more complex effects on RGC development than expected. (7/8)

[Bob Johnston @BobbyJEyeGuy]

Check out this "epic" summary of our recent paper from Michael Housset and @MichelCayouette !
https://t.co/Cg0KS56D9T

[biorxiv_devbio @biorxiv_devbio]

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids https://t.co/GNQEx15S1w #biorxiv_devbio

[Jingliang Simon Zhang @simonational]

New #preprint‼️Excited to share my PhD work, in which we characterize waves of cell death during human retinal development, and show how blocking apoptosis promotes RGC long-term survival and alters their developmental dynamics in #organoids. Check this out:

[Bob Johnston @BobbyJEyeGuy]

Check this paper from @simonational in our lab!
https://t.co/VWPFgFkKfI
Human retinas/organoids go through 2 apoptotic waves. Organoids also have a necrotic wave. Blocking apoptosis promotes RGC survival to day 200 (usually die!). Apoptosis promotes normal neurogenesis/maturation

[Taekjip Ha @taekjip]

GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion

https://t.co/LbRmYoghXG

[Jingliang Simon Zhang @simonational]

Congrats Darwin!

[Darwin Kwok @DarwinKwok1]

My first-author PhD thesis work is published in @Nature ! 🧬🔬🎉 I’m beyond grateful for this moment and for everyone who supported me! @NeurosurgUCSF @OkadaLabUCSF1 @josephcostell14 @KlebanoffLab

RNA Splicing aberrations generate tumor-wide neoantigens! https://t.co/z8dGr9n9cI

[Jingliang Simon Zhang @simonational]

Congrats Wenbin!!

[Wenbin Mei @wenbin_mei]

EXCITED to share my PhD work in @CellCellPress. We found that the chance of developing metastasis is partly decided by the DNA we inherited. We identified a germline variant in PCSK9 present in 70% of the white women conferring higher risk of breast cancer metastasis. (1/9)

[Jingliang Simon Zhang @simonational]

Heading out of town for 2024 #cshlbrain at @cshlmeetings to dive into the fascinating world of brain organoids! Happy to chat about my research on protecting human retinal ganglion cells, and to explore how to remake connections between the eye and the brain in vitro! 👁️🤝🧠

[Danielle Beckman @DaniBeckman]

A forest of neurons inside your head, happy #FluorescenceFriday 🔬🧪🧠

[Simon Duerr @simonduerr]

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https://t.co/qYzIsbr0TH

[Bob Johnston @BobbyJEyeGuy]

If you're at #ISER2024, come out to my talk on Thursday Oct 24, where I'll describe our "hourglass hypothesis" for extrinsic control of retinal developmental timing.

Session: Early retinal development and patterning
Time: 8:48
Work from @_chrisT3na @JoannaHagen2 @simonational

[Jun Axup Penman @junaxup]

The fly connectome map completed!! So beautiful!

[Lasker Foundation @LaskerFDN]

“My message to the young people is this: if I can get so close to the stars, you can too.” —Zhijian “James” Chen, 2024 #LaskerAward winner for his discovery of cGAS, an enzyme that senses self and foreign DNA
#Lasker2024 #LaskerLaureate @UTSWMedCenter