FriendsOfSinclairLab

The amazing group of people who support our research aimed at reversing aging in order to treat diseases and dramatically extend healthy lifespan

[FriendsOfSinclairLab @sinclairfriends]

After a decade of work, it’s exciting to see the labs’ cellular reprogramming tech going into patients. Thank you to all the scientists who worked hard to make this possible and congrats to the entire @lifebiosciences team! 🚀

[David Sinclair @davidasinclair]

FDA greenlights Life Biosciences' human clinical trial on a "near total reset"
https://t.co/KvTsw9SVI1

[David Sinclair @davidasinclair]

Great to be back!

https://t.co/Zam2JMrttx

[Longevity Science News @LongevitySNews]

Scientists stopped muscle aging in mice.
Blocking Hmgb1 in middle-aged mice with antibodies had remarkable results: senescent markers dropped, muscle regeneration improved, physical performance increased, and inflammation decreased.

[David Sinclair @davidasinclair]

Congrats @lifebiosciences team. Big thanks to our investors. Well done Jerry McLaughlin, Michael Ringel, Amit Shashank, Sharon Rozenzweig-L, Ivan Kaplan, @Serenapoon & team. Go ER-100🤞
Not sure we qualify as “startup” after 8 yrs & being in the clinic 😉
https://t.co/IJHx2SkTSR

[Lifespan @JoinLifespan]

Age reversal is natural

[David Sinclair @davidasinclair]

Best article in years

[Lifespan @JoinLifespan]

Can’t wait for you to see the new episodes of Lifespan. Sign up & receive early access & bonus material. Launch April 2026 https://t.co/W8lX18IH81 ✌️

[David Sinclair @davidasinclair]

Can’t wait for the first robot to present their findings at lab meeting

[FriendsOfSinclairLab @sinclairfriends]

👏 👏 👏

[Daniel Shur @teleodaniel]

Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG.

Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry.

In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward.

Michael also sits on the US board of @hevolution_f and on the board of the @AFARorg.

Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech!

0:00 Intro
2:30 Why aging is an optimization by evolution
15:10 Why scientists miss the role of evolution in aging
19:31 Evidence that aging is a regulated process
24:40 Hormesis and adaptive stress responses
28:55 The promise of partial epigenetic reprogramming in humans
35:08 Life Bio's first therapy proceeding to clinical trials
47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice
52:03 The pharma industry's perspective on anti-aging research
56:39 The importance of public engagement for funding and policy change
1:05:42 Reasons for optimism in longevity
1:08:26 Advice on how to have an impactful and interdisciplinary career
1:11:54 The ethical case for longevity
1:17:34 Concrete steps for audience members to support longevity research

[Yuri Deigin @ydeigin]

Oh wow — so cool to see two of my favorite examples that I’ve been using in my talks for close to a decade (rockfish lifespans spectrum from 10 to 200 years and the black garden ant queen’s 30-year lifespan vs. the worker’s 1-year [rather than a month — I think Michael misspoke]) getting wider airtime as evidence that aging is a programmed adaptation. The more people making this case, the better!

Here’s a video with relevant excerpts:

[FriendsOfSinclairLab @sinclairfriends]

@adityasinghnx @davidasinclair Great advice. With too much writing on a slide, the brain isn’t focused on what you’re saying either

[David Sinclair @davidasinclair]

Every week, I tell one of my students to increase the font size on their slides, especially numbers. Here’s how you know you’re good:

Take 5 steps back from your laptop or monitor. If you can still read every letter & number clearly, you’re probably good 👍

[FriendsOfSinclairLab @sinclairfriends]

@davidasinclair 👊✊☝️

[FriendsOfSinclairLab @sinclairfriends]

👊

[David Sinclair @davidasinclair]

For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy

Looking back, it was 100% worth it

Here’s why you should believe in yourself… 🧵

[FriendsOfSinclairLab @sinclairfriends]

Be discerning about companies whose mailing address is the someone's home and the office is in a mall

[Longevity Science News @LongevitySNews]

BREAKTHROUGH 100% Life Extension Achieved in Mouse Study
@ImmortaBio
https://t.co/oWnzJrMUDe

[David Sinclair @davidasinclair]

According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility

In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁

New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet

Why's that important? 🧵

[David Sinclair @davidasinclair]

The paper: https://t.co/29yv9MxfEu

[David Sinclair @davidasinclair]

In 2006, we reported the longevity & metabolic benefits of resveratrol in mice

Now, after 40 human trials with 2,551 patients, resveratrol is reported to significantly lower insulin resistance, lipids, BP & inflammation

Discovery. Translation. Progress.
https://t.co/tWylUPMq2Q

[nature @Nature]

Exercise prevents brain ageing and memory loss by strengthening the blood–brain barrier

https://t.co/O7v9yALtI4

[Dr Brad Stanfield @BradStanfieldMD]

It FINALLY happened!!!!
The Rapamycin & Exercise clinical trial manuscript has been accepted

5 years in the making

Special thanks to @mkaeberlein, @LifespanNews, @vitadao, everyone who donated, and viewers of my channel.

[David Sinclair @davidasinclair]

Longevity’s strongest correlate is having a dependable partner.

We are creatures whose optimal biology requires tight social bonds, presumably because our ancestors’ survival once depended on them.

For optimal health, rebel against today’s antisocial society 💪