Developmental, Stem Cell & Cancer Biology

Understanding the molecular and genetic mechanisms of a variety of developmental disorders and paediatric diseases to improve global child health outcomes.

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models. @cirunalab @SickKidsNews
https://t.co/qFXOsq2nx7
https://t.co/QPEIQ8o5iN

@SickKidsNews @CIHR_IRSC @NatureComms @sickkids @UofT @mogen

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Great work being done by postdocs in @yunli lab in the @SKDevStemCell program at SickKids.

https://t.co/zuE3TZjzEl

[Peter Dirks @BrainSurgn1989]

Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm

https://t.co/UByt8IWTk3

[Augusto Zani @augusto_zani]

Great job @FabianDoktor and the @Zani_Lab! Another important paper highlighting the effects of #EVs on fetal hypoplastic lungs 🫁! @SKDevStemCell @Me4Ped @cdhintl @CDHUK_CHARITY

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

@matt_eroglu @wbderry Congratulations @matt_eroglu and @wbderry

[Matthew Eroglu @matt_eroglu]

Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵https://t.co/K0tfW4PIoi

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Ulcers increase the risk of gastric cancer, but the mechanisms underlying this association remain unclear. The Kim and Guo labs demonstrate that YAP signaling promotes both gastric regeneration and metaplasia, a precancerous lesion. https://t.co/vnPX9LeYHm
https://t.co/jkDyoHqYbi

[Xi Huang @XiHuang18]

Weifan's paper has been featured on the cover of Nature Cancer @NatureCancer

[The Hospital for Sick Children (SickKids) @SickKidsNews]

A newly discovered protein-protein interaction has sparked the development of a novel treatment for #glioblastoma 🧠

Published in @NatureCancer, the #SKResearch team is now working to advance this therapy into clinical trials as soon as possible.

Read ➡️ https://t.co/VC56GsSIzv

[Xi Huang @XiHuang18]

Today, we report in @NatureCancer a new approach to treat glioblastoma (GBM). First and foremost, this is the work of recently graduated Dr. Weifan Dong, who has championed this study for the past 7 years with ingenuity and perseverance. @SickKidsNews @SKDevStemCell @MoGen_Grad

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

@augusto_zani @CIHR_IRSC @Zani_Lab @SickKidsNews @UofTSurgery @CDHUK_CHARITY @cdhintl Congratulations @augusto_zani and the entire Zani Lab team!!

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Great work!! Congratulations!

[Xi Huang @XiHuang18]

Excited to share our paper "Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes" https://t.co/1vDksLhbYm, led by our extremely talented postdoctoral fellow Xian Wang.

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Kim https://t.co/jkDyoHrw0Q and Wilson https://t.co/kQbBwOs6jN labs at SickKids have defined the epigenetic regulation of mesenchymal niche signals in stomach and intestinal development.
https://t.co/xF202H8Aek

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

@birendav3 Great work @birendav3!!!

[Neuron @NeuroCellPress]

First 2023 issue is out! https://t.co/ImgPc6zCsX
Cover art by Siqi Ou illustrates Chen & coll. findings on mechanosensitive brain tumor cells that form the blood-tumor barrier to mask chemosensitivity
Paper: https://t.co/Rb8awBs4kN
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[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

@XiHuang18 Congratulations Xin and all the best in your scientific endeavours!!

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Dr. Tae-Hee Kim's lab https://t.co/jkDyoHIz2Q identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis.
https://t.co/TXkxt3VndX

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Congratulations Dr. Vijay Ramaswamy @vijayvijay1979 for Canada Research Chair award (Tier II) to identify weaknesses in medulloblastoma and ependymoma, the first and third most common paediatric brain cancers.
https://t.co/E4mmnERbwb
@SKDevStemCell @SickKidsCancer @sickkids

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

@farmgirlphd We are no longer giving the hybrid option because when we did, in person attendance was very poor.

[Developmental, Stem Cell & Cancer Biology @SKDevStemCell]

Great work from @XiHuang18 lab.
https://t.co/pnUJEmJmhs

@SRC_CRS @CIHR_IRSC @SickKidsCancer @braincancercan @NoBrainCancer

[The Hospital for Sick Children (SickKids) @SickKidsNews]

A SickKids team led by Dr. Xi Huang has uncovered the mechanics of the blood-tumour barrier, laying the foundation for more effectively treating medulloblastoma, the most common malignant paediatric brain tumour.

Read more ➡️ https://t.co/EFJ3TEj2dI #SKResearch