Jan Škoda

Principal Investigator at the Laboratory of Tumor Biology, @MasarykUni & Leader of the Laboratory Oncology Translational Research group, @FNUSA_ICRC

[Jan Škoda @SkodaLab]

🔥 Hot off the @cddpress. Our paper on a novel #therapeutic #vulnerability to overcome multidrug resistance in #neuroblastoma has been published in Cell Death & Disease!
https://t.co/3DrWKB5zgE

@Kaja_Borankova et al.🧑‍🔬@BiologieUstav @FNUSA_ICRC @ChildrensPhila @syd_health

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[Jan Škoda @SkodaLab]

🚨 We're hiring! A 2.5-year (full-time) #Postdoc position available in my lab @muni_cz. 👇 Apply now & join us to study mitochondrial synthetic lethality in MYC-driven tumors. 📅 Deadline: 21 March 2025. (official e-application link will follow)

Please repost 💚

[Jan Škoda @SkodaLab]

That's it, I guess it's time to go 👉 https://t.co/jmSt6EaQKs
Hope to see you there. Last one out turn off the lights... 😉

[Jan Škoda @SkodaLab]

@petesoi1 That's amazing, congrats! 🎉

[Jan Škoda @SkodaLab]

A tremendous effort by the first author Lucie Curylova! 👏 Huge thanks to my team @MasarykUni @FNUSA_ICRC and all collaborators @FNBrno @CEITEC_Brno. Funded by @agentura_azvcr, with institutional support from @NUVR_CZ @ZdravkoOnline 🙏

[Jan Škoda @SkodaLab]

🥳 Excited to share our new paper on #pediatric #sarcomas! Restoring p53 tumor suppressor activity offers a promising approach to target aggressive, cancer stem-like cells in these childhood tumors: https://t.co/aM7wVKHpjj

@MasarykUni @FNUSA_ICRC @agentura_azvcr
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[Jan Škoda @SkodaLab]

Finally, as all patient-derived models were wild-type p53, our findings suggest that restoring the p53 signaling could offer a promising strategy for treating refractory/metastatic p53-overexpressing pediatric sarcomas, regardless of their TP53 mutational status.

[Jan Škoda @SkodaLab]

@SvobodaLab 👍🤣

[Jan Škoda @SkodaLab]

An interesting take on why conventional chemotherapy actually works or fails in cancer treatment 👇

[Anthony Letai MD PhD @DrTonyLetai]

Hugues de The and I want to remind you that nothing has cured more cancer patients than conventional chemotherapy!!! Think you understand how it selectively kills cancer cells so well? Take a look inside. @DanaFarber @DanaFarberNews

[LifeScienceAlliance @LSAjournal]

New study by @Kaja_Borankova @SkodaLab unexpectedly reveals that depleting the mitochondrial fission mediator DRP1 does not impair pediatric sarcoma chemoresistance and growth, ruling out DRP1 as a therapeutic target in these tumors. @MasarykUni @FNUSA_ICRC

https://t.co/RrpBjLphch

[Jan Škoda @SkodaLab]

Stressful life events during pregnancy and certain congenital pathologies are independently associated with NB risk https://t.co/nE4B4PhABs 👀 Interesting study that nicely aligns with the identified serotonin-mediated feedback loop in development & NB 👇 @adameykolab @PKameneva

[Igor Adameyko @adameykolab]

Did you ever wonder why pregnant woman should be careful about being #stressed? Our new paper in Nature Communications describes a mother-to-child link, which influences the development of #adrenalglands though the molecule for happiness #serotonin.
https://t.co/3KQjJALhrm
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[Jan Škoda @SkodaLab]

🚨 Our study reveals that DRP1-targeted strategies for sarcoma therapy are likely to fail 💊 #GAČR @NUVR_CZ. This was our first time publishing with @LSAjournal, and I can only commend the quality of the editorial process-just like with EMBO J. 👍 Highly recommended! 😉

[Jan Škoda @SkodaLab]

Happy to see the 2nd paper from @Kaja_Borankova's PhD finally out in @LSAjournal 🤩👇 A yet-to-be-characterized DRP1-independent mechanism compensates for mitochondrial fission & cell survival in drug-resistant pediatric sarcomas. @MasarykUni
@FNUSA_ICRC

https://t.co/bAkgFNdcDI

[KarolinaBorankova @Kaja_Borankova]

📢Check out @SkodaLab's latest preprint: Depletion of chemotherapy-responsive #mitochondrial fission mediator #DRP1 unexpectedly does NOT mitigate #sarcoma 💊chemotherapy resistance.

@Kaja_Borankova et al.🧑‍🔬🔬@BiologieUstav
@FNUSA_ICRC @NUVR_CZ
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https://t.co/ngAehvcaj1

[Jan Škoda @SkodaLab]

@0lgaPiskareva @NeuroblastomaUK @Prof_H_McCarthy @MF_Segura @DKFZ @unisouthampton @vallhebron @TissueEngDublin @RCSI_Research @RCSI_Irl @RCSIPharmBioMol Congrats!!! 🎉🥳👏 Amazing news!

[Jan Škoda @SkodaLab]

@0lgaPiskareva Many thanks, that's very kind of you 🤗 It's fantastic news and I feel very fortunate that I've been able to develop this line of research with such talented and motivated individuals. It's a success of many 😉🙏💚

[Jan Škoda @SkodaLab]

🎉 Celebrating in style 🥳 Delighted to share that we've received a grant from GAČR! We will dissect mitochondrial stress signaling to elucidate its role in regulating the “undruggable” MYC proteins for therapies of MYC-driven tumors. 🚨 We're hiring a postdoc! Full posting soon.