Duncan Smart PhD

@VanderbiltMSTP student interested in inflammation in cardiovascular disease. Longhorns, Mavs, film, and music.

[JAMA @JAMA_current]

Single subcutaneous doses of zilebesiran significantly lower blood pressure for up to 6 months, suggesting potential for use as an effective antihypertensive with quarterly or biannual dosing.

Read the KARDIA-1 RCT:
https://t.co/gFFqCDyzB8

[Jean Wassenaar @Jean_Wassenaar]

Looking forward to working with @MichaelR21 @JeffHsuMD and @VasRes to learn about all the exciting translational work coming out of #JACCBTS!

[Michael Raddatz @MichaelR21]

Excited to join the #JACCBTS social media team—it has quickly become a journal in which to find and publish high-quality cardiovascular research.

Follow the entire team for more great work published in #JACCBTS! @JeffHsuMD @VascRes @Jean_Wassenaar @JACCJournals

[Meena Madhur @CVimmunology]

Thank you @CVR_TomaszGuzik and @ESC_Journals for highlighting our recent publication with this invited editorial! https://t.co/RIP6VfkJsH
@smartdunc @DJFehrenbach @AmandaDoranLab @Jean_Wassenaar #HeartFailure #Trem2 #cardioimmunology

[J. Sawalla Guseh, M.D. @JSawallaGusehMD]

When Einthoven introduced the ECG to the world, he uniquely labeled its parts PQRST, inspired by mathematicians who used Ps & Qs in coordinates. Yet, he believed there was more to find, so he started in the alphabet's middle, leaving room for new discoveries on both sides.

1/n

[Duncan Smart PhD @smartdunc]

Woah. CCR2+ myeloid cell imaging in the human heart. Can’t wait to see this applied more broadly in CV diseases. Amazing work from Lavine at al. Great example of translating mechanistic preclinical findings to humans

[Nature Cardiovascular Research @NatureCVR]

RESEARCH| Lavine et al. establish the feasibility of C-C chemokine receptor 2 (#CCR2) #imaging, a marker of inflammatory monocytes/macrophages, in patients that suffered a #MyocardialInfarction| @LavineLab, Yongjian Liu, @WUSTL https://t.co/wt0EcoylUm

👉https://t.co/M3bd7C36dk

[Hypertension @HyperAHA]

Cardiometabolic Effects of DOCA-salt in Mice Depend on Ambient Temperature @JLGrobe @fekete2003 @nakagawapablo @curtsigmund

https://t.co/WRxqmllfLe

[Meena Madhur @CVimmunology]

Celebrating our transitions and next steps #Madhur Lab #Alexander Lab #WillMissThisGang!! ⁦@DJFehrenbach⁩ ⁦@smartdunc⁩ ⁦@Jean_Wassenaar⁩ ⁦@VascRes⁩ ⁦@VUMC_MedPSTP⁩ ⁦@VUMC_Medicine⁩ ⁦@VUMCClinPharm⁩ #GreenHillsGrille

[Duncan Smart PhD @smartdunc]

@MatthiasNahrend Thanks for highlighting our paper! Lots more to learn about Trem2 in cardio metabolic disease

[Daniel J Drucker @DanielJDrucker]

First oral semaglutide made a strong impression in OASIS-1 #obesity with 15% #weightloss now orforglipron leads the impressive pack of new small molecule oral GLP-1RA with robust #Weightloss and good tolerability ADA2023

[Duncan Smart PhD @smartdunc]

Many thanks to all my coauthors who made this possible! Excited to share this story in its final form

[Daniel Fehrenbach @DJFehrenbach]

@smartdunc's first first-author paper is finally in press! @CVResearch "Immune profiling of murine cardiac leukocytes identifies Trem2 as a novel mediator of hypertensive heart failure" https://t.co/mswzQ6vJqd @CVimmunology @Jean_Wassenaar @AmandaDoranLab @VAgrawalMDPhD

[Duncan Smart PhD @smartdunc]

@CVimmunology @Jean_Wassenaar @DJFehrenbach @VascRes Thanks!

[Harriette Van Spall, MD MPH 🇨🇦 @hvanspall]

Clinical benefits of #SGLT2is in #HF do not appear to be mediated by changes in myocardial #energetics based on this small mechanistic RCT conducted in
patients with #HFrEF & #HFpEF

#EMPAVISION https://t.co/KlHOrJwPgy

[Vanderbilt Molecular Physiology & Biophysics @VanderbiltMPB]

Join us in one week as @ThaoDVLe, graduate student in the lab of Julio Ayala (@TheBurro34), defends her thesis titled "Identification of Intracellular and Physiological Targets Transducing the Weight-Lowering Actions of Glucagon-Like Peptide 1 Receptor Agonists!"

@VanderbiltMSTP

[Duncan Smart PhD @smartdunc]

@TheBurro34 @MolMetab @ThaoDVLe Congrats!! @ThaoDVLe

[Duncan Smart PhD @smartdunc]

Excited to see this officially out!

[ASN Kidney360 @ASNKidney360]

Hypertension is the leading modifiable risk factor for worldwide morbidity & mortality. This study describes the role of T cells in hypertension & hypertensive end-organ damage & outlines potential therapeutic targets https://t.co/0QywvkDFak

@DJFehrenbach @VascRes @CVimmunology

[Duncan Smart PhD @smartdunc]

Excited to share a portion of my thesis work soon! For those who can’t attend in person, please reach out and I will share a zoom link!

[Vanderbilt Molecular Physiology & Biophysics @VanderbiltMPB]

In two weeks @smartdunc, a graduate student in the lab of Meena Madhur, will defend his thesis titled "Inflammation in hypertensive cardiac remodeling and heart failure."
We can't wait to see you there and here all about this work!

[Vousden Lab @LabVousden]

1/ We are delighted to see our study on the effect of sucralose on T-cells was published today in @Nature!

Time for a tweetorial 🧐 (with GIFs 🤠)

[Duncan Smart PhD @smartdunc]

@AzuahTheShort Congrats!