This has been an extensive collaborative team effort! Thanks to @em_ka_gu @JonathanBrento2@mgrantpeters@ZhongboC ReginaHReynolds @lcolladotor AineFairbrother-Browne and many more from our lab (RytenLab https://t.co/WKqMQgtTYQ)🥼🧑🔬👨🔬👩🔬🧪
New in @NatureComms: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration https://t.co/KapUzy4OQP
Overall, this in-depth characterisation of splicing accuracy can expand our understanding of the role of inaccuracies in ageing and neurodegenerative disorders.
Methods 📐In this work, we investigate splicing accuracy using short-read RNA-sequencing data from >14k control samples and 40 human body sites, focusing on split reads partially mapping to known transcripts in annotation.
First: we are proud to present RBPamp, a biophysical model of protein-RNA interactions and associated algorithm to query affinity of proteins for different RNA sequences from RBNS data https://t.co/TCYdk3OCEo
Great first day at #icar2024. Moving accounts on the impact of #ataxia on those affected, advances in disease modelling, promise of therapeutics on the horizon & keynote from @NINDSdirector on many exciting initiatives! Looking forward to the next few days!
A new BBC documentary explores the discoveries made by researchers at @ucl and UCLH that have given hope for #AlzheimersDisease, and the family that helped make it happen.
Watch #jenningsvsalzheimers on @BBCTwo 9pm 13 May 2024.
Read more https://t.co/4tvZ5p3yjK @brain_appeal
Physicist Peter Higgs has passed away at the age of 94. The Higgs particle, often called the God particle, is named after him.
Higgs was awarded the 2013 physics prize for the theory of how particles acquire mass.
Watch our interview with him: https://t.co/GnWRXnsyGx
SQANTI3 is the latest version of the SQANTI tool, offering a flexible approach for quality control, curation, and annotation of long-read RNA sequencing derived transcriptomes. @anaconesa@ConesaLab
https://t.co/ffz6oSufGL
Non-coding mutations can lead to rare disease too! @PacBio detected de novo mutation of lncRNA CHASERR leading to rare syndromic neurodevelopmental disorder https://t.co/jOoTNC3M9F
"I am truly excited to lead our brilliant team of researchers and collaborators in pushing the boundaries of science and unlocking vital understanding."
New UK DRI at Cambridge Director Prof Mina Ryten in @CambridgeIndy ⬇️
https://t.co/yXBag8ROos