Y. Sotani

University of Electro-Communications

[Aging Science News @AgingBiology]

The regeneration model of aging and its practical implications
https://t.co/0cwrcEDeg0

[William A. Wallace, Ph.D. @WilliamWallace]

New research shows how exercise protects aging muscle by rebalancing mTORC1.

In young muscle, mTORC1 is carefully regulated, allowing protein building while still clearing out damaged components. With aging, this balance breaks down. A transcription factor called DEAF1 becomes overactive, driving mTORC1 too hard, impairing cellular cleanup (autophagy), and accelerating muscle loss (sarcopenia).

Exercise reduces DEAF1 activity, restoring this balance and improving muscle repair and strength. Animal studies confirm the mechanism: lower DEAF1 improves power, while excess DEAF1 causes weakness.

The findings help explain why exercise benefits vary with age and point to DEAF1 as a potential target for therapies that support healthy muscle aging.

https://t.co/0S1TSA1yYH

[Science Magazine @ScienceMagazine]

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a Science study from earlier this year in mice.

The results suggest a potential new target for treating obesity-related metabolic disease. https://t.co/F3JkkCx0kj

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Excited to announce I've been appointed the inaugural Editor-in-Chief of a NEW nature portfolio journal - Exercise Medicine and Health: https://t.co/RmSJgbPAqq

Please contact me if you have questions about potential submissions or an interest in serving on the editorial board.

[Slava Bobrov @slava__bobrov]

A simplified overview of brain functions

#neuroscience

[骨格筋研究@産総研 @R_Ogasawara_Lab]

筋収縮による筋肥大メカニズムについてまとめた総説がPhysiological Reviewsから出ました！
@DrMikeRoberts を中心に、この分野の第一線で活躍している研究者が協力して、筋肥大メカニズムについて分かっていることの全てが分かるように執筆しました（引用文献923編！）。ご一読ください！