Aaron

Chemist, inventor, software developer. - Los Angeles

[Aaron @soychemist]

@BernardoFariaJJ I think that is Jason Rau? Sorry to drag you into this!

[Aaron @soychemist]

@Osint613 Yes, your account is one of the very few that keeps me on X.

[Aaron @soychemist]

Very interesting

[Sue @suekhim]

AI is making kids dumber.

It should be making them geniuses.

Introducing Koji, the first AI tutor that gets kids to actually think. 👇

[Aaron @soychemist]

Cutting weight for my first amateur MMA fight, should I try retatrutide-maxxing? #enhanncedgames #jklol

[Eric Topol @EricTopol]

Retatrutide, the triple receptor (GLP-1, GIP, glucagon) most potent weight loss drug yet seen (w/ 28% body weight reduction), pushes the limits, introduces some risks, by @PostRowland
gift link
https://t.co/v9XrXc7vBJ

[Aaron @soychemist]

Worth reading.

[Avi Roy @agingroy]

Two shots a year. No daily pills.

Zilebesiran, an RNA interference injection given every 6 months, lowered systolic blood pressure by 14-17 mmHg in patients whose daily medications weren't working.

1.3 billion people worldwide have hypertension. About half of those prescribed daily pills don't take them consistently. That compliance gap kills more people than treatment limitations do.

@Roche and @Alnylam are now enrolling 11,000 patients in the Phase 3 ZENITH trial.

Serious adverse events so far: 3.6% in the treatment group vs 6.7% on placebo.

For a condition defined by medication non-adherence, the most important innovation isn't a better drug. It's a drug that works when patients don't remember to take it.

[Aaron @soychemist]

@chrissyfarr The conclusion we have arrived at is that screens are fine, slop on screens is not.
PBS Kids, Sesame Street, Duolingo, Zelda ✅
Influencer Content, Blippi, Minecraft, Roblox ❌

[Aaron @soychemist]

Estonia should have won
https://t.co/AiXqKsQRod

[Aaron @soychemist]

nuts > data

[Colin McCarthy @US_Stormwatch]

Insane stat of the day: California almonds use roughly 3–5.5 million acre-feet of water per year, depending on methodology.

That's ~4-7x more water than all data centers in North America used combined in 2025.

[Angelica Parente (in SF June 9-11) @draparente]

Guys, this is why companies spend a lot of resources doing rigorous internal testing for protein quality. You cannot trust the claims from vendors, you'll hear plenty of horror stories from people who have been in the industry long enough.

Now apply this thinking to grey market peptides.

[Aaron @soychemist]

13 year olds all over LA are cutting across traffic like lemmings in on these F*ing things

[Temu @shoptemu]

Temu brings you luxe car upgrades without the luxe price tag.

[Aaron @soychemist]

The decline in quality of life for the working class.

[WarMonitor🇺🇦🇬🇧 @WarMonitor3]

What will the decade of 2020 to 2030 be remembered for in history?

[Aaron @soychemist]

Prediction: 🇺🇸 🫸🇹🇼 ⬇️ 🚌

[Open Source Intel @Osint613]

Chinese Foreign Ministry:

The pursuit of Taiwan independence is a dead end and its days are numbered.

[Aaron @soychemist]

Legit @jockowillink

[The Associated Press @AP]

WATCH: Taiwanese grandmothers aged 89 and 91 train at the gym. An increasing number of elderly people in Taiwan’s super-aged society are hitting the gym to stay healthy, both physically and mentally.

[Aaron @soychemist]

If you need work on your roof or drainage, get it done asap.

[Edgar McGregor @edgarrmcgregor]

The route for hurricanes to go make landfall in Southern California will be.... hot this year.

Hmm.

[Aaron @soychemist]

@DronePilotIL כל חייל צריך שיהיה לו את זה עם תחמושת טונגסטן. https://t.co/Ts8nTTfGUk

[Aaron @soychemist]

It's like that trick from the Princess Bride with the two cups of wine! Exposure => Tolerance

[Sheel Mohnot @pitdesi]

Feed your babies delicious Bamba snacks to help prevent peanut allergies!

Bamba is actually how they discovered this.

Jewish kids in the UK have 10x peanut allergies as Israeli Jews, they studied it and determined it was bc Israeli kids ate Bambas.

[Aaron @soychemist]

@EricTopol @heidiledford @Nature It seems like PP-405, named after the freeway and discovered by UCLA faculty, will be very good for hair.

I'm nervously monitoring TRG-035 in case I need new teeth at some point.

[Aaron @soychemist]

@DronePilotIL Watch This
https://t.co/qV79ovOt3z

[Aaron @soychemist]

True that. I just started on the "Wonder Woman" stack:
Every week I go to an IV clinic in a posh mini mall and they hook me up to a drip with prolactin, kisspeptin, oxytocin, relaxin, inhibin, and activin.
#kidding

[Bryan Johnson @bryan_johnson]

Everyone's injecting peptides. Almost no one is measuring what they actually do.

I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the benefits don't.

Tirzepatide didn't work for me. I'm already top 1% on glucose control and body composition, so the marginal upside was small. And even at 20% of the starting dose (0.5 mg/week), my resting HR climbed 2–3 bpm. Even granting it might return to baseline in a couple weeks, not worth it.

So I'm testing whether I can stack two peptides with opposite side effects and get the best of both worlds.

Tirzepatide: metabolic optimization, yet raises my HR and can disrupt my sleep.

CJC-1295 (a GHRH agonist that drives my own GH and IGF-1): growth and repair, but can blunt my glucose control and cause insulin resistance.

Opposite vectors on autonomic tone. Opposite vectors on glucose. On paper, the side effects cancel but the benefits don't.

That's my hypothesis. Now I'll measure it.

Two CJC-1295 variants on the table:
• DAC: weekly injection, extended half-life
• No-DAC + Ipamorelin: daily, before bed

The peptide community leans no-DAC, assuming it better preserves pulsatile GH release, with fewer side effects. However, the published data on DAC is better than the public consensus gives it credit for: sustained GHRH signaling without abolishing pulses, 7.5x overnight GH trough, >150% IGF-1 increase after two weekly doses at 30 µg/kg.

I'm starting with DAC, weekly dosing of the long-acting version, and monitoring side effects closely. If they're intolerable, I'll switch to no-DAC + Ipamorelin, daily.

Here’s my protocol, taking it easy on the dose, since DAC peptides are long acting:

Week 1
1.2 mg CJC-1295 DAC

Week 2
2.4 mg (or switch to no-DAC + Ipamorelin if side effects demand it)

Weeks 3 and 4
2.4 mg CJC-1295 weekly + 0.25 mg tirzepatide, twice weekly

Measuring everything:
• Weekly blood: IGF-1, GH, GHRH, fasting glucose, insulin, HOMA-IR, ApoA1, ApoB, prolactin, cortisol
• Continuous CGM across all 4 weeks
• Continuous core body temp (eCelsius capsule), weekly
• Sleep, HR, HRV: 24/7

I'll post results as they arrive.

[Aaron @soychemist]

@DronePilotIL צפו בזה.
https://t.co/QfNk1RQLGO