SPEC Caltech

Single-cell Profiling and Engineering Center, Beckman Institute

[SPEC Caltech @SPEC_Caltech]

maximally informative. Her method is very resource efficient, allowing her to compute >1M cells on a fairly typical AWS instance. https://t.co/1elUgnAldV

[SPEC Caltech @SPEC_Caltech]

Congrats to Xiaoqiao Chen for her first first-author publication today in Nature Computational Science. Xiaoqiao's method assembles small lists of highly informative genes using an iterative SVM method. She uses a clever 'active' strategy to only prioritize cells and genes that

[SPEC Caltech @SPEC_Caltech]

Really excited about this work from @Allan_HPool, showing how missing genes due to intronic reads and poor 3' annotation can be recovered with optimized reference transcriptomes.

[Allan-Hermann Pool @Allan_HPool]

First Pool Lab pre-print: https://t.co/e3vDzRXPrr. We resolve a major pain with 3’ single-cell RNA-sequencing (10x Genomics etc.) – missing gene expression data from thousands of genes. This stems from suboptimal reference transcriptomes and can easily be recovered. T below: 1/12

[SPEC Caltech @SPEC_Caltech]

We are hiring!! Looking to hire a research technician to execute a focused project on exploring human cell surface proteins on the human immune system using single-cell RNA-seq. https://t.co/R0ZaJXNjs4

[SPEC Caltech @SPEC_Caltech]

Congrats @Pselaphinae and @AdrianBrueckner!! Nice to see this beautiful story finally in print!

[SPEC Caltech @SPEC_Caltech]

Whoohoo!! Congrats @Wonderstrucksci

[Inna-Marie @Wonderstrucksci]

It's so fun to let loose and get creative with @mitchguttman @sofiquinodoz. We developed a great idea and I'm pleased to see my art on the cover of @CellCellPress today. Plus there's more fantastic work from Guttman Lab @Caltech inside.

[SPEC Caltech @SPEC_Caltech]

Congrats to @dibidave @AltermattMi and @cosmotat for their new paper on determining AAV cell type specificity using single-cell RNA seq!

[SPEC Caltech @SPEC_Caltech]

Really cool spatial-sequencing method from UCSF. Have been talking with Eric about this for quite some time... Cool to see it finally in print! XYZeq: Spatially resolved single-cell RNA sequencing https://t.co/uOAIZjV9PL

[SPEC Caltech @SPEC_Caltech]

Congrats to all of the authors for a beautiful new paper! We were happy to support the single-cell profiling experiments in this very intriguing EPES synthetic embryo system.

[Magdalena Zernicka-Goetz @ZernickaGoetz]

My heartfelt thanks for this work to my institution @Caltech @PDN_Cambridge @Cambridge_Uni My wonderful lab @MZG_Lab and especially @BernaSozen_ , my first Caltech PhD student Victoria Jorgensen, my PhD student in Cambridge @BailWeatherbee, and wonderful @sisichen & @zhumeng123

[SPEC Caltech @SPEC_Caltech]

Super cool work from @BEuplotes and @WallaceUcsf !

[Wallace Marshall @WallaceUcsf]

Nice article by @mjflepage in @newscientist about the work or @BEuplotes on how the walking gait of single cell Euplotes may be controlled by a microtubule based computer. I feel this piece poses the big question and sums up the key points in a super clear way! @I2CELL

[SPEC Caltech @SPEC_Caltech]

Congrats David and Tatyana! @dibidave @cosmotat

[dibidave @dibidave]

The preprint for my main PhD project is out! https://t.co/pHulRbd43Y. We characterize the cell types in the brain (cortex) that get targeted by different AAV gene therapy vehicles (in mice ;) )

[Caltech @Caltech]

We are proud to recognize professors Dianne Newman and Jonas Peters for their election to @americanacad.

This election is a recognition of "extraordinary people who help solve the world’s most urgent challenges ... and contribute to the common good..." 👏

[Laurien Van Dyck (she/her) @VanDyckLaurien]

Really enjoyed the talk of Sisi Chen at #RNGS21!
The team combines popAlign and multiseq to unravel distinct drug responses in immune cells, leading to exiting yet sometimes unexpected discoveries🤯
😯I will watch out with artificial sweeteners...

[SPEC Caltech @SPEC_Caltech]

Well-deserved!

[Caltech @Caltech]

Congratulations to Rob Phillips, who was recently awarded Caltech's top prize for excellence in teaching. One nominator cited Phillips's "remarkable ability to make scientific discovery feel special." https://t.co/qljE8VvZEr

[Phys.org @physorg_com]

Engineers place molecule-scale devices in precise orientation @Caltech @sciencemagazine https://t.co/gUJpLScjd4

[VIB @VIBLifeSciences]

Single cell research will be a major focus during #RNGS21, presented to you by some of the leading figures in this field. Check out the full program: https://t.co/WW3kljLfWC
⏰registration deadline: 26 Feb #transcriptomics #genomics #proteomics #multiomics #singlecell #sequencing

[Sisi Chen @sisichen]

So thrillled that our work received the SLAS2021 Innovation award!!! Truly a team effort @SPEC_Caltech with
@TamiKhazaei, @cmcginnisUCSF, @ZevGartner, Eric Chow at @CAT_UCSF, Matt Thomson, Jeff Park, and Tiffany Tsou (now grad student at NYU)

[SPEC Caltech @SPEC_Caltech]

What's cool: capillary blood sampling devices (TAP devices) allowed them to collect blood at high temporal frequencies (morning and night) to study diurnal variability in a cell type-specific and patient-specific manner.

[SPEC Caltech @SPEC_Caltech]

Congrats to @cosmotat @dibidave, Jeff Park and Matt Thomson for their paper on single-cell profiling of capillary blood!
https://t.co/GPYDgSNATm