Anyone who has ever done microscopy everโข๏ธ
zzz
ใ๏ผโ๏ผใฝ-๏ฝค_๏ผฟ_
๏ผ๏ผ_/๏ผฟ๏ผฟ๏ผฟ๏ผฟ๏ผ
๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ
ใใใโง_โง i didnโt turn off
ใใ (ใ๏ฝฅฯ๏ฝฅ) the lasers
ใ ๏ผฟ|ใโ๏ผ(๏ผฟ๏ผฟ_
๏ผใโ-(๏ผฟ๏ผฟ๏ผฟ_๏ผ
๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ๏ฟฃ
๐๏ธJaneliaโs Gerry Rubin talked to NPR about the fly brain connectome, how it could help scientists begin to compare the brain wiring of different species & whatโs next for connectomics and neuroscience.๐ง
https://t.co/NE3jMauCZS
Brave and important. A #mentalhealth podcast special. Hear first hand experiences from two hugely successful scientists, Beth Cimini and Kedar Narayan. Whilst a serious issue, it is very much a relaxed, engaging chat.
See/Hear - https://t.co/dEFlykGnHk
#TheMicroscopists
Pls retweet
It was great to present at the @PeterMacRes Tech day this week, showing off the capabilities of @CahmPmcc 's recently installed @zeiss_micro Lattice Light Sheet 7 microscope!
Time-lapse imaging of tumour cells expressing a fluorescent actin binding peptide, Lifeact-GFP ๐๐ป
๐ขGOOD NEWS!
The Africa Microscopy Initiative, in partnership with @zeiss_micro will distribute refurbished research-grade light microscopes to African Scientists.
Read more and APPLY: https://t.co/WLcJckSCPE
Deadline: 13 September 2024
This month's Focus on advanced AI in biology also contains a series of Comments from leaders in their respective fields, who discuss the broad impacts that AI-based methods are likely to have on many areas of biological research.
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
TIRF-SIM was a game changer for us to figure out actin dynamics in T cells. Big thanks to Dong Li, @shaomumu and @Eric_Betzig- I was very lucky to work with you all at Janelia. Now who can do this in 3D in the context of a true T cell synapse??! #FluorescenceFriday
#FluorescenceFriday#cellbiology#immunology#Actin dynamics at the immunological synapse (IS) between a Jurkat T cell and an antigen-presenting coverslip, as seen by total internal reflection structured illumination microscopy (TIRF-SIM). John Hammer's group #NIH used our TIRF-SIM to show that formins rearrange inward flowing actin filaments from the outer lamellipodial band of the IS into circumferential arcs that establish the peripheral supramolecular activation cluster, which in turn concentrates T cell receptor microclusters at the center of the IS. https://t.co/XuFawsimD6
Life has been pulling me away from the scope (I had a baby named Henry!), but #FlourescenceFriday never takes a break. CAD cell with a dual tag myosin 2 construct - green on the motor heads and magenta on the tails, giving a๐ข๐ฃ๐ขtriplet. Can even see a few processive runs๐โโ๏ธ
๐ฌ๐คExcited to share our new preprint on robust virtual staining of key organelles! https://t.co/w8eBziTyMz
โจ Virtual staining and segmentation of nuclei and cell membranes in phase images can significantly accelerate image-based screens and developmental studies.
๐ Current virtual staining models often struggle with nuisance variations in label-free input and don't generalize well to new cell types. Weโre releasing our training protocols that lead to robust models and enable few-shot generalization.
๐ง Stay tuned for our revamped codebase with weights and example data, coming soon!
๐๐งซ๐ Huge shoutout to @ZW_Liu, @edyoshikun, my team @czbiohub (Soorya, Johanna, Christian, @TalonChandler, @ieivanov1), and the teams of @LeonettiManuel, Carolina Arias, and @Adrian_Jacobo for this fun collaboration!
#VirtualStaining #DL #CellBiology #Zebrafish
The search is on....
We are recruiting at the assistant professor level!
Come join us!!!
Assistant Professor job with Loyola University of Chicago - Cell and Molecular Physiology Department | 12818067 (https://t.co/Uro0poZlal)
Canโt emphasize enough for folks who are new to crafting slide decks in pharma/biotech: less is more. Lead with key points, go to details if time permits. Convey with graphics & minimize text. If youโre in 10-12 point font, youโve lost the plot. Leave ample time for discussion.
Canโt emphasize enough for folks who are new to crafting slide decks in pharma/biotech: less is more. Lead with key points, go to details if time permits. Convey with graphics & minimize text. If youโre in 10-12 point font, youโve lost the plot. Leave ample time for discussion.
Today, we introduce the new ZEISS Celldiscoverer 7 โ your microscope with adaptable automation for advanced imaging workflows!
ZEISS Celldiscoverer 7 now features higher acquisition speed, and supports more versatile experiments and new applications. Here is what's new:
๐๐ถ๐ด๐ต๐ฒ๐ฟ ๐ง๐ต๐ฟ๐ผ๐๐ด๐ต๐ฝ๐๐
Enjoy up to 9 times faster widefield and up to 1.8 times faster confocal image acquisition.
๐ก๐ฒ๐ ๐๐ถ๐ด๐ต๐ ๐ฆ๐ผ๐๐ฟ๐ฐ๐ฒ
Shorter exposure times enable more sensitive imaging, reducing phototoxicity and bleaching.
๐๐ฟ๐ผ๐ฎ๐ฑ๐ฒ๐ฟ ๐ฆ๐ฝ๐ฒ๐ฐ๐๐ฟ๐ฎ๐น ๐ฅ๐ฎ๐ป๐ด๐ฒ
Seven excitation lines including 735 nm far red give you maximum flexibility in the choice of dyes.
๐ก๐ฒ๐ ๐๐ฎ๐บ๐ฒ๐ฟ๐ฎ๐
Get higher sensitivity, signal to noise, and speed with ZEISS Axiocam 807 mono and 820 mono.
๐๐ฑ๐๐ฎ๐ป๐ฐ๐ฒ๐ฑ ๐ช๐ผ๐ฟ๐ธ๐ณ๐น๐ผ๐๐
Full support of auto-immersion objectives significantly improves Guided Acquisition workflows.
๐๐๐ฐ๐น๐ถ๐ฐ ๐๐บ๐ฎ๐ด๐ถ๐ป๐ด
Include different sample carriers in an experiment to acquire advanced time series.
๐ฆ๐ฐ๐ฎ๐ป๐ป๐ถ๐ป๐ด ๐๐ฟ๐ฒ๐ฎ
A new sample holder maximizes the travel range for full coverage of chamber slides.
๐ฆ๐ต๐ฎ๐ฑ๐ถ๐ป๐ด ๐๐ฎ๐น๐ถ๐ฏ๐ฟ๐ฎ๐๐ถ๐ผ๐ป ๐ ๐ฎ๐ป๐ฎ๐ด๐ฒ๐ฟ
Let individual users apply their custom shading corrections to different samples.
๐๐ฎ๐๐ฎ ๐๐๐ฎ๐น๐๐ฎ๐๐ถ๐ผ๐ป
A new viewer introduces more options for observing and comparing data in multi-well experiments.
๐ฆ๐๐๐๐ฒ๐บ ๐จ๐ฝ๐๐ถ๐บ๐ฒ
Excessive endurance testing and preventive service options ensure reliable long-term operation.
Learn more about ZEISS Celldiscoverer 7, its product features, and explore application examples: https://t.co/iQHUXICtEq
#celldiscoverer7 #hcs #hca #drugdiscovery #cellculture #imaging #microscopy
VR isn't just for gaming. Researchers can literally step into their 3D datasets, tagging voxels for ground truth and setting the stage for advanced 3D deep learning.
#microscopy#bioimageanalysis#deeplearning
Interesting answer to the inexorable loss of momentum of๐ฏ๐ตpharma R&D
Takeda $TAK, #Astellas and #Sumitomo Mitsui Banking Announce Master Agreement to Establish Joint Venture Company for Incubation of Early Drug Discovery Programs (R&D originating from๐ฏ๐ต) https://t.co/UoqM6v91LF
We engineered hyper-migration into CART cells to dramatically enhance their infiltration into solid tumors.
We tested this strategy for ovarian, lung, and pancreatic cancer.
The contrast with control CAR T cells is ....you decide.
More here: https://t.co/ObfvUjKxFX
Tracking neuron lineages, movements, molecular identities & activity in a developing zebrafish spinal cord. Credit to Dr. Philipp Keller @HHMIJanelia. #ZebrafishZunday
#FluorescenceFriday#cellbiology#bioart
The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute:
Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.
https://t.co/H9kU2qeuPb