Stephen McConnell

[Stephen McConnell @StephenMc55]

@MohammedAlo Niacin (Vitamin B3) supports memory and cognitive health by protecting brain cells from stress and assisting cellular energy metabolism.
Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011–2014

https://t.co/rsmsRqSsrb

[Stephen McConnell @StephenMc55]

@MohammedAlo Pay close attention. Not thousands, but we’ve observed dozens in the last 25 years who experienced loss of memory, some severe with actual amnesia. Discontinuing atorvastatin solved the problem. Cause-and-effect. If your patients complain of memory loss, you leave them on statin.

[Stephen McConnell @StephenMc55]

@MohammedAlo Statins DECREASE Desmosterol which is the precursor to cholesterol. So, ApoB is unable to deliver cholesterol to cells in the brain, which is unique to the entire body. To compensate it needs cholesterol from its own ability to synthesize. Suppressed= less cholesterol for brain.

[Stephen McConnell @StephenMc55]

@MohammedAlo https://t.co/uQkLnZuNmG

[Stephen McConnell @StephenMc55]

@MohammedAlo The Role of Desmosterol in Dementia Risk: Implications for Brain Health and Therapeutic Strategies

https://t.co/cNTCvx76PD

[Stephen McConnell @StephenMc55]

@MohammedAlo Alzheimers Dement (Amst). 2015 Mar 29;1(1):67–74. doi: 10.1016/j.dadm.2014.11.009

Reduced plasma desmosterol-to-cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease

https://t.co/28YawkelZK

[Stephen McConnell @StephenMc55]

@MohammedAlo “Low plasma desmosterol levels are linked to mild cognitive impairment and Alzheimer's disease as a marker of altered brain cholesterol synthesis,..”

https://t.co/2aBalOVFJg

[Stephen McConnell @StephenMc55]

@MohammedAlo In the present study in older people from the general population we did not find an association between treatment with statins at baseline and cognitive decline
at five-years follow-up.

[Stephen McConnell @StephenMc55]

@MohammedAlo https://t.co/Ow50gOo0pO

[Stephen McConnell @StephenMc55]

@MohammedAlo https://t.co/yhhnk9TIBJ

[Stephen McConnell @StephenMc55]

@davidasinclair

[Stephen McConnell @StephenMc55]

@markkaplan20 Maybe because Cardiology is a surgical profession. They spend most of their time doing surgical procedures, and actually have little knowledge of how the disease brought them to the Cath Lab. The best console would be with a Lipidologist, not a cardiologist.

[Stephen McConnell @StephenMc55]

@SABOURETCardio I see. So what is “your list”,.. ??

[Stephen McConnell @StephenMc55]

@EricTopol @NEJM OK Voters
We all understand what needs to be done

[Stephen McConnell @StephenMc55]

@whitfieldlewis6 @theproof “A good reason why niacin has not disappeared. It requires a spine to use it, and not just an opinion based on no clinical experience. A swimming instructor, who actually cannot swim, shouldn���t offer opinions on swimming.”

https://t.co/kADjDECrx3

[Stephen McConnell @StephenMc55]

@theproof

[Stephen McConnell @StephenMc55]

@theproof NIACIN DENIAL ??
Open to opposing views ??

“A good reason why niacin has not disappeared. It requires a spine to use it, and not just an opinion based on no clinical experience.

https://t.co/kADjDECrx3

[Stephen McConnell @StephenMc55]

@DrM_ODonoghue @jspellos A good reason why niacin has not disappeared. It requires a spine to use it, and not just an opinion based on no clinical experience. A swimming instructor, who actually cannot swim, shouldn’t offer opinions on swimming.

https://t.co/kADjDECrx3

[Stephen McConnell @StephenMc55]

@mdavidsonmd A good reason why niacin has not disappeared. It requires a spine to use it, and not just an opinion based on no clinical experience. A swimming instructor, who actually cannot swim, shouldn’t offer opinions on swimming.

https://t.co/kADjDECrx3