Steven Zhao

[Steven Zhao @SteZhao]

@GongDennis FYI https://t.co/dKschV8wr8 and other papers from this group. Addresses some of your thoughts.

[Steven Zhao @SteZhao]

3/ This PhD would suit candidates with backgrounds in epidemiology, biostatistics, bioinformatics, data science, genetics, computational biology, medicine or related quantitative/biomedical disciplines.

Interested candidates: please get in touch for an informal discussion.

[Steven Zhao @SteZhao]

1/ @PsoriasisUK funded #PhD @OfficialUoM:

𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐡𝐞𝐚𝐥𝐭𝐡 𝐜��𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐩𝐬𝐨𝐫𝐢𝐚𝐭𝐢𝐜 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐝𝐢𝐯𝐞𝐫𝐬𝐞 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬

https://t.co/cZscaERufw

UK fees + UKRI stipend. UK applicants only.

[Steven Zhao @SteZhao]

2/ Use linked health + genomic data from @ukfuturehealth and @AllofUsResearch to study how comorbidities cluster, accumulate and causally relate to #psoriasis and #PsoriaticArthritis across diverse populations.

[Steven Zhao @SteZhao]

@AberdeenEpi @PhysioWillGreg @KarlGaffney1 @RheumatologyUK @LindsayTurnerPM So true. We were joyous the rest of the video, except this frame 😅

[BSR @RheumatologyUK]

📢 We are delighted to share our newly-updated clinical guideline for the management of axial spondyloarthritis! Read more: https://t.co/6KrJ5zmpXK

@NASSexercise
@BritspaUK

#guidelines #rheumatology #axSpA

[Dr Ai Lyn Tan @DrAiLynTan]

📢Do you work in #Rheumatology or #Dermatology in the UK?

Please help us understand the impact of #obesity on #psoriasis and #PsoriaticArthritis
👉🏽https://t.co/J1TvDHVk6V

[Marios Georgakis @MariosGeorgakis]

A great new resource for phenome-wide genetic explorations by the Estonian Biobank🇪🇪🧬

👉206,159 participants
👉GWASs for 4,884 ICD-10 diagnoses
👉2,127 unique GWAS loci
👉778 putatively novel locus-phenotype associations

[Marios Georgakis @MariosGeorgakis]

A GWAS meta-analysis for sarcoidosis in 9,755 cases and 1,526,867 controls🧬

In diseases like sarcoidosis, where we know little about etiology, GWAS can be much more interesting, as they provide pathogenesis insights with potential for informing therapeutic strategies

[Dr Ai Lyn Tan @DrAiLynTan]

#PhysicalActivity for those with chronic widespread pain & #fibromyalgia effective in

✅Reducing #pain & #depression
✅Enhancing quality of life

🔹Intense physical activity has strongest protective effect

#MetaAnalysis
👉🏽https://t.co/tDfyziRZv2

[Steven Zhao @SteZhao]

*these results replicate an earlier candidate gene study of TYK2 and sarcoid https://t.co/okQPAnqncm

[Steven Zhao @SteZhao]

The largest #GWAS of #sarcoidosis to date identifies 28 susceptibility loci and implicates CCDC88 and #TYK2* genes.

MR suggested causal roles of IL-23R and IL-2Rβ, and risk increasing role of #BMI. @Yuan_AS

https://t.co/J9OhEFhuFc

[Steven Zhao @SteZhao]

This study compares #apremilast and #methotrexate (that have more similar efficacy for cutaneous psoriasis) to see if targeted therapy reduces PsA risk independent of skin control.

[Steven Zhao @SteZhao]

🚨#Apremilast (#Otezla) is associated with⬇️risk of #PsoriaticArthritis compared to #methotrexate among people with cutaneous #psoraisis (HR 0.85, 95%CI 0.79, 0.91).

Research funded by @PsoriasisInfo

https://t.co/E0nRQdZJVt

[Steven Zhao @SteZhao]

However, a key limitation is that IL-17/-23 inhibitors have superior efficacy for controlling cutaneous disease, the severity of which is an independent risk factor for PsA onset.

[Steven Zhao @SteZhao]

This research was funded by @PsoriasisInfo

[Steven Zhao @SteZhao]

🚨The incidence of #uveitis and #IBD in psoriatic disease, and vice versa, is not well described.

This study shows, among other things, that uveitis and IBD incidences are higher in #PsA than cutaneous-only #psoriasis and higher in females than males.

https://t.co/gF8yKJ3poq

[Steven Zhao @SteZhao]

🚨#Tofacitinib ⬆️ #cardiovascular & #cancer risk in RA. But how relevant is this risk to people with #AxialSpondyloarthritis or #PsoriaticArthritis?

This study did not find⬆️risk of JAK compared to TNF/IL17 inhibitors in SpA. Funded by @PsoriasisInfo https://t.co/jCutAt1rRJ