Stojdl Lab

We share cutting-edge #science & work on making great #oncolytic #virus immunotherapies to treat #cancer. Tweets by @swiftsciwriting

[Stojdl Lab @StojdlLab]

The @StojdlLab has now moved from working in an academic space to an industrial one. This gives us a strong translational platform to get our #oncolytic immunotherapies to the #cancer patients who need them. Visit https://t.co/KRe6Pw6qIO to track our progress. #immunotherapy

[Brain Canada @BrainCanada]

This project by @StojdlLab is a great example of the kind of promising research being supported by Brain Canada in the field of brain cancer. To date, we have invested nearly $11M in support of work in this area #BrainTumourAwarenessMonth https://t.co/syRcOB4EAK

[Stojdl Lab @StojdlLab]

Can the site of metastasis predict treatment outcomes in #cancer patients treated with #immunotherapy ? https://t.co/JKBRcaaJrZ Interesting #OA #research from @MDPIOpenAccess @SapienzaRoma Image credit: Botticelli et al. 2020 #openaccess #metastasis

[Stojdl Lab @StojdlLab]

Prime/boost treatment of #HIV patients with Ad26/Vaccinia #virus #vaccines generates robust #immune responses but only delays time to viral rebound for several days compared to placebo: https://t.co/4fTztzYLLR via @NatureMedicine #immunology #vaccination #publichealth

[Stojdl Lab @StojdlLab]

Nice @Cancer_Cell review of intratumoural #heterogeneity, including its sources, ways to capture and account for it during clinical decision making, and potential strategies to improve therapeutic outcomes by directly targeting it: https://t.co/5mgFOwPBxZ #cancer #immunotherapy

[Stojdl Lab @StojdlLab]

Great @CellCellPress perspective piece describing the Human Tumour Atlas Network (HTAN), which will chart tumour transitions across space and time at the single-cell level https://t.co/xpuzg8uoXd via @broadinstitute #cancer #immunotherapy #OA #dataviz Image: Rozenblatt-Rosen 2020

[Stojdl Lab @StojdlLab]

Visualising T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones: https://t.co/u8NXn7f8nq via @ImmunityCP @UniofOxford #OA #immunology #immunity Image credit: Chauveau et al. 2020

[Stojdl Lab @StojdlLab]

Sequencing of serially passaged #oncolytic measles #virus demonstrates genomic stability and a robust safety profile for clinical applications: https://t.co/ObQLVcCllZ via @MicrobioSoc @DKFZ @OttawaHospital Image credit: @CDCgov

[Stojdl Lab @StojdlLab]

Interesting model describes how spatial structures, such as solid tissues and diffusion liquids, may impact the ability of viruses to avoid innate #immunity during #infection: https://t.co/4LCKJvGZh1 via @PLOS @CSIC #virus #virology #OA Image credit: Segredo-Otero & Sanjuán 2020

[Stojdl Lab @StojdlLab]

Long-term responses to PD-1 #immune checkpoint blockade are associated with stroma remodeling and reduced expression of tumour cell proliferation markers in mice & patients w/ skin #cancer https://t.co/UX6ILgxPc4 via @NatureComms @OfficialUoM #immunotherapy #OA Image Galvani 2020

[Stojdl Lab @StojdlLab]

Nice @jitcancer review of T cell-targeted #immune checkpoint inhibitor therapies in brain #cancer - where we are, and how we can achieve clinically meaningful benefits: https://t.co/LnySrHfHQ3 via @theNCI #OA #openaccess #immunotherapy #immunecheckpoint #glioma

[Stojdl Lab @StojdlLab]

Exciting new @SpringerNature protocol book chapter on #oncolytic viruses, with a great focus on the immunotherapeutic effects of oncolysis, immunomodulation and immunomonitoring: https://t.co/DLFWH4f1Dp H/T @DKFZ #virus #cancer #immunotherapy #virology #immunology #immunity

[Stojdl Lab @StojdlLab]

Interesting review of the tools, methods & trends for the visual analysis of #cancer-related #genomic #data, and the serious challenges that still need to be overcome to derive clinical meaning from big datasets https://t.co/ma9tsz274t #OA #bigdata #datavisualisation Image Qu2019

[Stojdl Lab @StojdlLab]

Say it with #Histology this #ValentinesDay❤️
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All images credited to @IHeartHisto
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#love #science

[Stojdl Lab @StojdlLab]

More #evidence suggesting that the use of #antibiotics within two months of starting #immune checkpoint inhibitor #immunotherapy may have a deleterious effect in patients with advanced #cancer: https://t.co/zUMapX2B8b via @SpringerNature @UniBasel @UniSpitalBasel @Unispital_USZ

[Stojdl Lab @StojdlLab]

Genome-wide CRISPR-Cas9 screening finds a HLA-independent T cell receptor that targets #cancer vs. non-cancer cells via the MHC class I-related protein, MR1, based on sensing the cancer #metabolome: https://t.co/IN7DJPeUak via @NatImmunol @cardiffuni @UofUMedicine #immunotherapy

[Stojdl Lab @StojdlLab]

New automated flow peptide synthesis technology produces 30-mer #neoantigen peptides in less than 35 minutes and 16-mers in less than 20 for personalised #cancer #immunotherapy: https://t.co/yj9QpiYjMt via @SciReports @MIT @broadinstitute @kochinstitute #OA Image: Truex 2020

[NSERC / CRSNG @NSERC_CRSNG]

#February11 is the International Day of Women and Girls in Science.

Let's celebrate Canada’s women in science past, present and future.
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#WomenInScience #WomenInSTEM #GirlsInScience #GirlsInSTEM
#WomenScienceDay #InternationalDayOfWomenAndGirlsinScience #CdnSci @WomenScienceDay

[Stojdl Lab @StojdlLab]

Genetically stable poliovirus vectors activate dendritic cells and prime anti-tumour CD8+ T cell #immunity in mice: https://t.co/J7TST6f9tM via @NatureComms @DukeU @UCSF #cancer #immunotherapy #oncolytic #virus #PVSRIPO #OA #openaccess Image credit: Mosaheb et al. 2020

[Stojdl Lab @StojdlLab]

Directing traffic: how to effectively drive T cells into tumours. Nice mini-review from @CD_AACR @DanaFarber @harvardmed @broadinstitute @BrighamResearch @AACR Image credit: Anandappa et al. 2020 #cancer #immunotherapy #combinationtherapy