Strained Rings

Strain chemistry insights | Recent papers, perspectives & breakthroughs | Where molecular stress meets discovery 🔬
Handled by @HariGroupIISc

[J. Am. Chem. Soc. @J_A_C_S]

Ladderanes: Stepping Up as Nonclassical ortho-Substituted Benzene Bioisosteres | Journal of the American Chemical Society https://t.co/3J0DjDGbV2

[Strained Rings @strained_rings]

🦋 Strain-driven radical elegance : NHC catalysis unlocks bicyclo[1.1.0]butanes for radical alkylarylation, forging densely functionalized 3-spirocyclobutyl oxindoles through controlled release of ring strain 🚀
@ChemCommun
https://t.co/5ImpFH51YB

[Elva Hu @elvahupin]

Diastereoselective Synthesis of Difluoromethylene—Bridged Cyclopropane-Cyclobutanes from 2-(Difluoromethylene)-cyclobutyl Sulfonium Salt and Cyclopropenes

https://t.co/bCF5nuXaLQ

[Strained Rings @strained_rings]

𖣘 Photochemical chloro-sulfoximidation unlocks the extreme strain of [1.1.1]Propellane, enabling radical difunctionalization into densely functionalized BCPs – light-driven access to high-value 3D bioisosteres 💡
@ChemCommun
https://t.co/Qwi4pqsnLk

[Strained Rings @strained_rings]

🦋 Dihalogenation-triggered strain-release cyclization of BCB carboxamides enables rapid assembly of dihalogenated spiro[cyclobutane-quinolinone] frameworks, extreme BCB strain sculpted into medicinally rich 3D architectures ⚡
@ChemCommun
https://t.co/wWJ73OMFWS

[Strained Rings @strained_rings]

🦋 Electrochemical anodic oxidation triggers relay cyclization to forge strained 2-oxa-bicyclo[2.1.1]hexanes, transforming simple precursors into rigid 3D bioisosteres—electrons unlocking strain-built molecular architecture ⚡🔋
@ChemicalScience
https://t.co/T2w4y1kkDO

[Strained Rings @strained_rings]

🦋1-Azabicyclo[1.1.0]butanes emerge as “spring-loaded” synthons for azetidine construction, where strain-release drives modular ring opening, skeletal editing & rapid access to sp³-rich N-heterocycles ⚡🔺
@ChemEurJ @Luisi_Lab
https://t.co/8aGDDk7Yx1

[Jacsol Joc @jacsoljoc]

https://t.co/qDJrXbDwoe

[Strained Rings @strained_rings]

🔺Strain rewrites diazo chemistry ⚡! Cyclopropanediazonium intermediates trigger ring-opening rearrangement, enabling fluorinative migration to access difluorinated scaffolds: small rings, bold reactivity 💥🔥
@angew_chem
https://t.co/IOL2Q3WGHt

[Strained Rings @strained_rings]

🔺 Cu-catalyzed chemodivergent ring-opening diborylation of strained vinylcyclopropanes exploits cyclopropane strain to forge distal 1,5-diboronates: ligand-controlled selectivity enables precise C–C cleavage and multifunctionalization ⚡
@ACSCatalysis
https://t.co/7cJAtl213B

[Strained Rings @strained_rings]

🦋 One strained BCB, two fates 🔺⚡! Catalyst choice (Ni vs Cu) directs carbene transfer: cyclopropanation or C–H insertion—harnessing “spring-loaded” strain for divergent, high-precision synthesis 💥🧪🔥
@angew_chem
https://t.co/m3Ob4jFBgF

[Strained Rings @strained_rings]

🦋 Strain-encoded reactivity of bicyclo[1.1.0]butanes exploited in a Yb(OTf)₃-catalyzed Schmidt–semipinacol sequence: controlled C–C bond cleavage/migration delivers architecturally complex N-heterocycles 🔥
@JOC_OL
https://t.co/cSwzg3Op0y

[Strained Rings @strained_rings]

🔺Carbonyls → carbenes → cyclopropanes ⚡ ! Fe catalysis converts simple aldehydes/ketones into strained cyclopropanes—no diazo, just elegant strain-building from everyday feedstocks 💥🔥
@J_A_C_S @MacMillan_Lab @PrincetonChem
https://t.co/s2SB1qS2XP

[Strained Rings @strained_rings]

🦋⚡Electrochemical activation unlocks strain-release of 1-azabicyclo[1.1.0]butanes, generating N-centered radical cations for divergent functionalization: electrons sculpt azetidines with precision and synthetic elegance 🔋
@angew_chem @PB_IITRPR
https://t.co/H1fFH1iZGU

[Strained Rings @strained_rings]

🦋 BCB strain goes alkyne-active ⚡! Phosphine catalysis drives strain-release alkynylation, converting tiny high-energy rings into richly functionalized cyclobutanes — small rings, massive synthetic power 💥🔥
@AdvSynthCatal
https://t.co/rc8VzHRGfY

[Silvi Research Group @SilviResearch]

Great to see our recent @J_A_C_S paper about the synthesis of 4-members rings from alkenes https://t.co/Qp7Evqu53c highlighted as Synfacts of the Month https://t.co/d2ZCul3ZED thanks @thiemechemistry for the recognition and well done to the team!

[Strained Rings @strained_rings]

𖣘 Rh(II) drives cascade annulation to build strained [4.3.1]propellanes—small-ring strain + carbene reactivity = explosive access to complex polycycles
@JOC_OL
https://t.co/Iu9qM8A6Hu

[Strained Rings @strained_rings]

🔺Strain forged under light : A photoredox-neutral acridine/Fe dual catalysis enables decarboxylative carbene generation, driving cyclopropanation—transforming simple acids into highly strained rings with elegance & efficiency 🚀
@ACSCatalysis
https://t.co/O4LefuGqSZ

[Strained Rings @strained_rings]

🔺Parallel kinetic resolution of highly strained aziridines enables enantioenriched chiral alcohols via divergent pathways—transforming ring strain into stereochemical elegance and synthetic power ⚡️
@ACSCatalysis
https://t.co/ui89suJIWJ

[Strained Rings @strained_rings]

⚡️ Strain sculpted into function: Enantioselective access to rigid bicyclo[2.1.1]hexanes transforms highly strained frameworks into meta-benzene bioisosteres—unlocking 3D chemical space with precision and elegance
@NatureSynthesis @TortosaLab
https://t.co/Fdb7tfqWQq