Tomokazu Sumida

Cardiologist, Immunologist

[Science Translational Medicine @ScienceTM]

In a new study, researchers utilize #epigenomic and #transcriptomic profiling of people with relapsing-remitting #MultipleSclerosis to identify pathways involved in regulatory #Tcell dysfunction in autoimmunity. @SumidaTomokazu @DavidHaflerMD https://t.co/OsjS4aB0OT

[Tomokazu Sumida @SumidaTomokazu]

@manoliskellis @xinchen_w @MelinaClaussnit @JasonErnstLab Thank you so much for your patience and generous mentorship, Manolis! It's been an incredible journey of over 7 years, and it’s been worth every moment. I’ve learned so much from your group!👑

[Tomokazu Sumida @SumidaTomokazu]

@Lloyd_Bod @ScienceTM @ypp_lab @DavidHaflerMD @manoliskellis Thank you Lloyd!

[Tomokazu Sumida @SumidaTomokazu]

1/ Excited to share our latest paper published in @ScienceTM! 🧬 https://t.co/cw8w876Ogi. This journey was a true team effort with @ypp_lab, Liang, and Matt, under the guidance of @DavidHaflerMD and @manoliskellis. Here's a breakdown of our findings.

[Tomokazu Sumida @SumidaTomokazu]

Thank you, Yongjin! This has been one of the best collaborations I've ever had. I’m so proud to be working with you, Liang, and Matt! Let’s keep up the great work together.

[Tomokazu Sumida @SumidaTomokazu]

13/ This work was a massive collaboration—thank you to everyone involved! We hope these findings pave the way for new insights into Treg dysfunction and autoimmune disease. Stay tuned for more!

[Tomokazu Sumida @SumidaTomokazu]

12/ Using CRISPRa, we pinpointed a specific regulatory element within the PRDM1 locus tied to PRDM1-S, with an AP-1/IRF composite motif. This supports our theory that these TFs are key in driving PRDM1-S expression.

[Anshul Kundaje @anshulkundaje]

Great paper. I strongly agree that causal gene regulatory network inference (i.e. where u can actually claim gene A causally and directly regulates gene B) using mRNA alone is impossible IMHO. Even from perturbation expts. I think this is impossible. 1/

[Tomokazu Sumida @SumidaTomokazu]

@ppaxisa @ScienceTM @tomomimyoshida @LaLilli11 @lucasite_lab @EricVerdin @DavidHaflerMD @YaleMed Beautiful work addressing “genotype-to-phenotype problem" by using both human and mice system. You rule! Congratulations, PP @ppaxisa!!

[Pierre-Paul Axisa @ppaxisa]

Thrilled to see our study out in @ScienceTM with @tomomimyoshida @LaLilli11 @lucasite_lab @EricVerdin @SumidaTomokazu @DavidHaflerMD during my time @YaleMed. We took a deep dive into the role of HDAC7 in Tregs in the context of #MultipleSclerosis risk.🧵https://t.co/tcuCUFEQnU