Sune K. Yang-Jensen

Postdoc at @TeamBenLab - @BiomedUCPH. Part of @CphGutHub team. Host-microbe interactions and immunometabolism. You are what your gut microbes eat

[Sune K. Yang-Jensen @sune_jensen]

6/
For those interested in gut barrier biology, GLP-2 signaling, or immune-epithelial cross-talk, the full open-access paper is worth a read.

📄 https://t.co/lvaKTtQslY

[Sune K. Yang-Jensen @sune_jensen]

🚨 New in @NatureComms

We report that a microbial lysate can activate the GLP-2 receptor (GLP-2R) and protect against gastrointestinal inflammation.

For those interested in IBD, mucositis, and gut barrier dysfunction - this may be of interest. 🧵👇 1/6

[Sune K. Yang-Jensen @sune_jensen]

5/
Rather than viewing microbiota solely as “composition,” this work highlights receptor-level host-microbe interactions.

A shift from:
“Which bacteria are present?”
to
“What host receptors are being engaged?”

Still preclinical — but mechanistically compelling.

[Waggoner Lab @LabWaggoner]

Microbial activation of the GLP-2R mitigates gastrointestinal inflammation
https://t.co/690JsnXTYe
@NatureComms 🇩🇰

[Daniel J Drucker @DanielJDrucker]

Gut barrier function, systemic inflammation and the pathophysiology of metabolic disorders #T2D #obesity https://t.co/C9IwIHuszY

[Sune K. Yang-Jensen @sune_jensen]

📖 Read more: https://t.co/MAx0d6YfUw

[Sune K. Yang-Jensen @sune_jensen]

🫁🧫Our new study in Gut Microbes shows cigarette smoke damages the gut barrier, enabling bacterial encroachment on the gut to aggravate lung inflammation.

Importantly, restoring the gut barrier or preventing encroachment improves lung health!

Link and more in comment!

[Sune K. Yang-Jensen @sune_jensen]

Proud of this impactful industry–academia collaboration pushing the frontiers of host-microbe interaction research! 🌍🤝 Thanks to everyone involved. @TeamBenLab @novonesis

[Sune K. Yang-Jensen @sune_jensen]

@BiomedUCPH covered this research in a recent highlight article, go check it out 💪 https://t.co/19bVpSqddT

[Sune K. Yang-Jensen @sune_jensen]

So grateful #LouisHansenFonden has granted us half a million DKK to explore the gut health-promoting potential in lysates from a soil microbe! At @TeamBenLab we will explore how this lysate can restore balance in the inflamed gut 🔬👨‍🔬 Important research for future IBD therapies!

[Sune K. Yang-Jensen @sune_jensen]

This project will expand on a previously published observations from @TeamBenLab, demonstrating a profound impact of the lysate on gut mucosal T-cells, gut microbiome, and metabolism. https://t.co/NMzoS7tTzw

[Sune K. Yang-Jensen @sune_jensen]

‘Leaky gut’ contributes to the low-grade inflammation seen in metabolic disease. Is fixing the leaky gut going to be a new obesity management strategy? Check out this new review discussing the GLP-2R as a potential target!

https://t.co/Ezfji0pgU0

@TeamBenLab @Filip_Knop

[ScienceNews @sciencenewsdk]

Understanding the intricate relationship between #gut microbes and host #immunity offers valuable insight for future #research.
#sciencenewsdk @TeamBenLab

https://t.co/C8YFtaXeyS

[ScienceNews @sciencenewsdk]

The global prevalence of #overweight and #obesity has nearly tripled in the past 50 years, and 40% of adults have overweight. A new #study shows that the effects of probiotics on obesity are difficult to predict.
#sciencenewsdk @TeamBenLab

https://t.co/1NyPNKvmKs

[Nature Reviews Endocrinology @NatureRevEndo]

Online now: A Journal Club from @sune_jensen and @BeatriceSY_Choi discusses a key paper outlining the influence of the gut microbiota on #obesity (£) https://t.co/JPUmEabAjc

[Sune K. Yang-Jensen @sune_jensen]

The gut microbiota has been proposed to play a role in a variety of diseases, including obesity. However, showing causality is not easy.

@BeatriceSY_Choi and I discuss this issue in our latest journal club out now in @NatureRevEndo - go check it out!

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Obesity is transferable through the gut microbiota https://t.co/kJwRdY30AW