Lu Sun

Assistant Professor at UT Southwestern Medical Center studying how glial cells sculpt the nervous system. Views are my own.

[Lu Sun @SunLab19]

Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.

[Lu Sun @SunLab19]

@YueluUIowa @ZhangTingxin Thanks and hope all is well with you and your new lab in Iowa!

[Lu Sun @SunLab19]

Today we say goodbye to @ZhangTingxin, an outstanding postdoc and research scientist in our group, as he begins his independent lab at SUSTech (the first one from our lab!). He published our group’s first paper and has another under review. Congratulations and best of luck!!

[UT Southwestern O'Donnell Brain Institute @UTSWBrain]

OBI Investigator, Lu Sun, Ph.D. (right), & Aksheev Bhambri, Ph.D., developed a new research tool that sheds light on myelination. Learn how the discovery is providing deeper understanding of how neurological disorders like multiple sclerosis develop. https://t.co/jlkuyQCFc8

[Lu Sun @SunLab19]

We made the Enpp6-CreERT2 mice available from Jax: https://t.co/JNmQa4LI6F

and updated the premyelinating oligodendrocyte multiomic website: https://t.co/vvPG0p4zU8

[Lu Sun @SunLab19]

Glad to share our published version: “ Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms”, led by @AksheevB

https://t.co/V09WCcX2A8

[Lu Sun @SunLab19]

@Zhu_Lab @science So inspiring to read Zhu Lab’s work, even though not in my field. Many congratulations!!

[Bill Dauer @BillDauerNeuro]

A terrific new opportunity for new or early career faculty to join the outstanding and rapidly growing faculty of @UTSWBrain. Spread the word!

[Lu Sun @SunLab19]

@guo_lab @NatureNeuro @YaleNeuro @Yale_INP Beautiful - Congratulations again, Junjie!!

[Eric N. Olson @Transactivator]

Thanks to everyone for an amazing Myo Life celebration of the 40-year anniversary of the Olson Lab, along with a big birthday. Here's my special song for the occasion, "The Ballad of Myo Life". Rock on! 😎 @UTSWMedCenter

[Lu Sun @SunLab19]

@EthanHughesLab @Sriram_S433 @YiheZhang97 Thanks, Ethan!

[Lu Sun @SunLab19]

Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.

[Lu Sun @SunLab19]

The two knock-in mouse lines for myelinating oligodendrocytes are Mog-IRES-iCre (JAX#041041) and Mog-IRES-iCreERT2 (JAX#041042) with high efficient and specificity (no tamoxifen-independent recombination). If interested, please let JAX know so that they will not be cryopreserved.

[Lu Sun @SunLab19]

@CellReports @YiheZhang97 This study was in a close collaboration with @yu_guoqiang group which decoded the CUT&RUN data. We are grateful for the generous support from @czi @klingensteinorg, fichtenbaum foundation, and others.

[Lu Sun @SunLab19]

@CellReports @YiheZhang97 Even more surprisingly, TFEB acts as a transcriptional repressor on these cholesterol genes, thereby reducing cholesterol levels when it is in the nucleus of myelinating oligodendrocytes.