Sun Lab JHU

We are the Sun Laboratory at the Johns Hopkins. Dr. Shuying Sun and her team are interested in RNA metabolism dysfunction and RNA-targeting therapy of ALS.

[Sun Lab JHU @sunlab_jhu]

Excited to share a new Neuron paper from our lab’s recent PhD graduate Ying. We identified DCPS as a modifier of TDP-43 loss-of-function toxicity and revealed that TDP-43 regulates RNA stability through P-body dynamics. https://t.co/LOvSdNXKqh

[Neuron @NeuroCellPress]

Online now: PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD https://t.co/0l14WoedNG

[Sun Lab JHU @sunlab_jhu]

Excited to share our latest work in Neuron! Using CRISPRi screening, we identified PTPσ as a key modifier of R-DPR-mediated neurotoxicity in ALS/FTD. Huge congrats to Zhe for her beautiful work! https://t.co/KSdcv5QpO0

[Sun Lab JHU @sunlab_jhu]

Happy Chinese New Year!

[Sun Lab JHU @sunlab_jhu]

🎄 Merry Christmas!!

[Sun Lab JHU @sunlab_jhu]

🎃 Halloween vibes in the Sun Lab! 👻 We swapped lab coats for costumes and had a lunch party with fun games!

[Sun Lab JHU @sunlab_jhu]

Today is the last day for our amazing postdoc, Yini Li. She is off to Purdue University to join the Borch Medicinal Chemistry and Molecular Pharmacology Department as an Assistant Professor! We'll miss the endless happiness and energy she's brought to the lab. Best of luck, Yini!

[Shuying Sun @shuying_sun]

Excited to present our work @NeuroCellPress . We found that the GGGGCC RNA repeats and poly-GR dipeptides synergistically impair nuclear speckle functions. This leads to global splicing defects, contributing to neurodegeneration in C9ORF72-linked ALS/FTD.
https://t.co/rrb9tbZVkg

[Sun Lab JHU @sunlab_jhu]

☀️Double acheivement in August! Congrats to postdoc Dr. Rong Wu for publishing in
@NeuroCellPress ! His work demonstrates that nuclear speckle is disrupted in C9ORF72-FTD/ALS, and leads to RNA mis-splicing and neuronal degeneration.https://t.co/EKTssBlbWY

[Sun Lab JHU @sunlab_jhu]

🔬Our post-doc Dr. Daoyuan Dong's latest paper on C9 ALS/FTD is now out! Her study reveals how poly-GR repeats impair translation elongation and induce ribotoxic stress in neurons. https://t.co/LP5dj0Upso

[Sun Lab JHU @sunlab_jhu]

Congratulations to Shuxian on receiving the ALS Association-Milton Safenowitz Postdoctoral Fellowship!!

[Sun Lab JHU @sunlab_jhu]

🎉 Big congrats to our lab's postdoc Yini Li for winning the Helen B. Taussig Research Award of the 47th annual Young Investigators’ Day! 🏆 Here’s to many more achievements on your incredible journey!

[Sun Lab JHU @sunlab_jhu]

Eclipse Monday🌘🌑🌒

[UMich RNA Center 〽️🧬 @umichrna]

Join us Monday, April 1, 4 PM #RNA Innovation Seminar Series: Shuying Sun, Ph.D., @HopkinsMedicine presents “RNA Metabolism in C9ORF72-linked neurodegenerative diseases ALS and FTD” https://t.co/VWojjv67Tu BSRB and Zoom https://t.co/zBdSiLnLvA @shuying_sun
#UMichRNA #UMichRNATx

[M W @Michael_E_Ward_]

We currently lack biomarkers for TDP-43, a protein that aggregates in ALS, FTD, and AD. We discovered that mis-spliced RNAs downstream of TDP-43 dysfunction are sometimes translated into abnormal proteins. These are present in patient biofluids, enabling future TDP-43 biomarkers.

[Sun Lab JHU @sunlab_jhu]

🏠🎉 What a cozy house party this Christmas! It’s time to take a break from the lab bench and have a jolly good time celebrating the season together!

[Sun Lab JHU @sunlab_jhu]

Our lab just published a new commentary on the recent paper by Chi. et al. in PNAS, discussing the connection between ALS and the immune system. https://t.co/F4oqyPlX2L… https://t.co/3KhQVxVO1I

[Rothstein Lab @Rothstein_Lab]

Antisense therapy: a potential breakthrough in the treatment of neurodegenerative diseases https://t.co/pQVyHUGdgc

[Sun Lab JHU @sunlab_jhu]

🔬🍲 Lab lunch today: A steaming hot pot, symbolizing the warmth and unity of our amazing team! 🎉 Celebrating our recent publication and lab move, all thanks to the dedication and hard work of each member!

[Rothstein Lab @Rothstein_Lab]

Disease related changes in ATAC-Seq of more than 450 iPSC-derived motor neuron lines from ALS patients and controls @AnswerALS https://t.co/dGBMCydYWY