PrudencioLab

Opinions are my own and not the views of my employer

[The Rainwater Charitable Foundation @RCFNeuro]

Dr. Timothy Miller, 2023 Rainwater Prize winner and Tau Consortium member, leads this @JAMANeuro article reporting long‑term Phase 3 and open‑label extension results in SOD1-ALS. Catch up on this example of bold, patient-focused science: https://t.co/MJGOUpEaJv

[ShorterLab @ShorterLab]

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification: https://t.co/Kz8qMDQgZg

[Alzforum @alzforum]

Loss of progranulin drives the buildup of TMEM106B fibrils in lysosomes, causing their membranes to burst. Risk variants in TMEM106B accelerate this process. @UMich @univmiami @NIH @Stanford https://t.co/vjPbtMHDkM

[Miller Medicine @umiamimedicine]

Dr. Leonard Petrucelli has joined the Miller School of Medicine as Founding Director of the Neuroscience Institute. Dr. Petrucelli is a visionary scientist and a global leader in neurodegeneration research. His seminal work has uncovered the molecular mechanisms underpinning Alzheimer’s disease, frontotemporal dementia and ALS. His research reveals novel biomarkers and therapeutic targets that will help shape the next generation of treatments, helping to improve the lives of patients facing these devastating diseases.

Welcome, Dr. Petrucelli! Read more: https://t.co/cg1WhyxxDb

[PrudencioLab @PrudencioLab]

https://t.co/DFOOMMv0vO

[UF McKnight Brain Institute @UFMBI]

The MBI community gathered today to honor longtime colleague Dr. David Borchelt.

Dr. Gopal Thinakaran, a close collaborator of Borchelt's, opened the First Annual David R. Borchelt Excellence in Neurodegeneration Research Seminar with a talk on BIN1’s role in Alzheimer’s.

[Target ALS @TargetALS_fdn]

Tracking #ALS early could transform care. Target ALS-backed scientists are developing blood & CSF tests for #CrypticPeptides—potential early biomarkers. Learn more: https://t.co/xAMWYVyuxC #ALSResearch #EveryoneLives

[Target ALS @TargetALS_fdn]

Dr. Leonard Petrucelli is a globally recognized leader in neurodegeneration and our longtime Scientific Advisor. He's been instrumental in shaping #ALSResearch and the very foundation of Target ALS. As he steps down from his role with us, we celebrate his partnership and vision.

[Gregory Day @GDay_Neuro]

NEW PAPER is out! We measured plasma p-tau217 and Aβ42/40 in 509 patients with the cognitive concerns. Worth a read if you're thinking of using blood-based biomarkers in the outpatient clinic.

https://t.co/G4Vq53DiTu

@PiuraYoav1 @MayoClinic @MayoClinicNeuro @mayocliniclabs

[PrudencioLab @PrudencioLab]

https://t.co/0JiSMwPqDk

[Rothstein Lab @Rothstein_Lab]

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7
https://t.co/jC0lzOaRPA

[PNASNews @PNASNews]

Join us in celebrating our 2024 Cozzarelli Prize Class IV: Biomedical Sciences winning paper, “Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis.” Read more: https://t.co/rR16Co9a4a

[Target ALS @TargetALS_fdn]

When #DanDoctoroff was diagnosed with #ALS, he saw an opportunity to make change. See what inspired him to found Target ALS to accelerate the discovery, development, and path to effective treatments.

Take action today: https://t.co/gfErNMXvhL

#ALSResearch #EveryoneLives

[PrudencioLab @PrudencioLab]

I was thrilled for the opportunity to present today at #ADPD2025 the work @PrudencioLab, in the wonderful city of Vienna where I was lucky to get an awesome tour by Dr Wilfried Rossoll!

[PrudencioLab @PrudencioLab]

Our manuscript got highlighted with a beautiful infographic!

#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS @PrudencioLab

DOI: https://t.co/bZfrXZCLpS

[ShorterLab @ShorterLab]

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes: https://t.co/omhuzu6pvw

[PrudencioLab @PrudencioLab]

@alyssawalk1 I am so excited Dr Walker @alyssawalk1 has joined @PrudencioLab
Looking forward to doing great work together!!

[Alyssa Walker, Ph.D. @alyssawalk1]

I joined the Prudencio lab at Mayo’s Department of Neuroscience as a Research Fellow last month! So exciting to be working on great science with this great group of ladies. #STEM #Neuroscience #TDP #TDP43 #proteostasis #proteinopathy #proteopathy

[Celeste Karch @karchlab]

Very proud of this new study from the lab! 🌟We identified a novel lncRNA, FAM151B-DT, that is disrupted across neurodegenerative diseases. https://t.co/tbGEsA9BYs

[ShorterLab @ShorterLab]

A novel lncRNA FAM151B-DT regulates autophagy and degradation of aggregation prone proteins: https://t.co/JuXpNblCNK