Shane Caldwell

Biochemist. Structural Biologist. Eukaryote.

[Shane Caldwell @superhelical]

Every time you say "trending towards significance", a statistician somewhere trips and falls down

[Shane Caldwell @superhelical]

I'm just going to say that it's reeeeeeally convenient that a disease that kept the world indoors and boosted Animal Crossing numbers could have been started by Tom Nook himself

https://t.co/dXR7BVs1Wv

[Shane Caldwell @superhelical]

@AirCanada Hi, I have an upcoming flight on Dec 27th. Both my passport and driver's licenses are up for renewal and I'm worried they won't arrive in time. I have my birth certificate and BC interim license, is this sufficient? Your website isn't clear on this.

[Shane Caldwell @superhelical]

@PassportCan Hi, my ppt application went in last month and I also just renewed my driver's license. I fly within Canada on Dec 27 and realized I have no photo ID for Air Canada. If I go to a passport centre to expidite, what ID will I need? I have a temp license but no photo now

[Shane Caldwell @superhelical]

It was worth a shot #ChatGPT #ASOIAF #windsofwinter #GameofThrones

[Shane Caldwell @superhelical]

@AirCanada hey! My wife left her phone on a plane we arrived at YVR on this evening. Is there anyone we can directly reach with Air Can at the airport to try to find it from lost and found?

[Shane Caldwell @superhelical]

Anyone who says topology isn't important has never tried to dress a toddler

[Shane Caldwell @superhelical]

@AlexanderRKlotz 80 A in the longest dimension, 52 perpendicular to that

[Shane Caldwell @superhelical]

@AlexanderRKlotz Send me the pdb id

[Shane Caldwell @superhelical]

@ichaydon @UW Would this be the first vaccine based on engineered nanocages? Or did RSV get there first?

[Shane Caldwell @superhelical]

@sokrypton @AlexanderRKlotz every time I see knots I assume you're interested

[Shane Caldwell @superhelical]

@sokrypton Lorenz attractor?

[Ian Haydon @ichaydon]

Here's how a close friend who is a brilliant scientist reacted to this news: "I see people in the streets, going about their lives, and I think 'they don't know how the world just changed.'"

Has there ever been a bigger, more impactful data drop in the history of biology?

[Shane Caldwell @superhelical]

@sokrypton @klausenhauser @zarivach @minkbaek @DeepMind Just noticed there aren't linkers there after all, are there? I made an assumption. Wow this is impressive

[Shane Caldwell @superhelical]

@sokrypton @klausenhauser @zarivach @minkbaek @DeepMind Wow! Impressive! Only thing is the catalytic N1-proline, but suppose it's easy to break the chain and relax once you have the model.

[Shane Caldwell @superhelical]

@sokrypton @klausenhauser @zarivach @minkbaek @DeepMind Edge case, but guess this wouldn't work for cases where termini aren't free? Thinking of PDB 4OTA

[Shane Caldwell @superhelical]

@aledmedwards Maybe I'm too young, why not prepare a saturated solution and mix in? Ends up too dilute?

[Shane Caldwell @superhelical]

@CaraSantaMaria I have a wtw suggestion: ligand. Mostly because it means kind of opposite things in chemistry vs. biology, which has led to many confusing exchanges in my biochemistry career.

[Shane Caldwell @superhelical]

Here's the work @ichaydon and I worked on at @UWproteindesign in collaboration with the Hilvert group and @CathleenZeymer lab. We think this is an important step to generate artificial enzymes completely from scratch. With metals rarely used in biology!

https://t.co/t75fPUVqhV

[Shane Caldwell @superhelical]

No one informed me that 73% of parenting is keeping them from eating dog food.

[Shane Caldwell @superhelical]

So great to be able to work with such a great team and to finally share this work!

The teams at @UWproteindesign and @CathleenZeymer's group continue to work hard toward the development of fully synthetic enzymes.

Glad to be part of one important step along the way.

[Ian Haydon @ichaydon]

[warning: non-COVID science]

My graduate research is out today! We created a protein that binds rare earth metals w high affinity. It's a new way for the living & non-living worlds to interact :)

w/ @superhelical, @CathleenZeymer et al

https://t.co/yxVW8avLhU