#PharmTox student Siyang Peng is studying the evolution of the #influenza virus through observing its transmission between ferrets. Her research, done within the @tcflab, is being supported by a Hilldale Undergraduate/Faculty Research Fellowship!
https://t.co/fwZhNpck9P
After 5 great years, I've wrapped up my time in the @tcflab! Grateful to everyone in the lab & esp to @tcfriedrich for being a great mentor. And now, I'm excited to start my postdoc tomorrow studying congenital CMV with @SalliePermar at @WeillCornell! 👩🔬
Where do new #SARSCoV2 variants come from? Unusually long infections in immunocompromised people may be one important source. New preprint with @HalfmannPeter@dho and many others to look at viral evolution in one individual with a very long infection. @itsnickminor has details!
New manuscript from my work at @dho_lab is up on medRxiv!
This was my first big project on staff there, and was an extraordinary opportunity to shift gears into viral genomics and public health.
So, what did we find?
Figures & findings in thread.
New paper on H7N9 influenza evolution within and between hosts from @KATarinambraun@haddocksoto and many wonderful collaborators! Kat has the details below.
📣We compare sequence evol’n of H7N9 #birdflu to H1N1 in ferrets. Purifying selection➕ stochasticity➕ tiny bottlenecks=human-transmissible H7N9 is unlikely to emerge from spillover infxs. BUT, every infx is a pull on the evolutionary 🎰slot machine🧵1/11 https://t.co/zpbllfidq6
What factors shape evolution of influenza virus within an individual? Happy to share our collaborative work led by @kaaamato with Luis and Kat and @tcflab, @SSCLabQuips, and @KoelleLab that shows genetic bottlenecks restrain intrahost influenza virus evolution. 1/10
Friday paper drop! Excited to see my second paper out in @PLOSNTDs today. Check out the thread below for details on our study of the impact of prior #DENV exposure on #ZIKV pathogenesis during pregnancy. Thanks to a great team for making this happen! @AliotaLab @tcflab
Love having amazing colleagues and VIROLOGY?
UW-Madison is looking to hire a new faculty member who loves working on viruses as much as we do! https://t.co/OcvvSxRKed
#COVID19 work continues for MSTP student @KATarinambraun alongside the labs of @tcfriedrich and @dho - “You know you want to be able to track how each of those viruses is circulating, which viruses are circulating, because it will save lives."
Preprint 🧵Using viral sequencing + some epi data, we show that a majority #SARSCoV2 infections in healthcare workers at our institution occur in the community and can only rarely be traced to a #COVID19 patient source. @GageKMoreno@dho @tcfriedrich 1/12 https://t.co/QWDtQc8LQq
There’s a lot of concern and confusion right now about the new #sarscov2 variant identified in UK. I’ve spent today and yesterday talking to a dozen people working on this. My story is here: https://t.co/HupLMpgHPt
Thread to come (may be long and slow)
Check out this thread from #MDTP student @chelsea_crooks4 on her new paper with MDTP trainers @tcflab and @dho_lab on African-lineage #Zika pathogenesis in pregnancy! 👇
Check out our preprint! We deep sequenced #SARSCoV2 viruses longitudinally before & after transmission in 🐱s. We observed narrow (& potentially non-random) transmission bottlenecks and argue cats may be a useful model. @GageKMoreno @tcfriedrich 🧵1/
https://t.co/4pSoUmiSB9