Adrian “WE NEED RCTS!” Hernandez

Father of 4 boys, cardiologist, clinical researcher- outcomes, clinical trials, health policy & innovative methods; Director DCRI; Vice Dean, Duke School of Med

[nancyatheart @NancyatHeart]

Medical research gives patients hope, advances new treatments and strengthens communities.

So pleased to see so many leaders and volunteers alongside @American_Heart Volunteer President @manesh_patelMD in Washington, D.C., advocating for independent science and continued support of medical research.

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Fun baseball.. this weekend almost hit for the cycle - single, double and triple then game ended before his 4th AB

[Prospect Select Scout @PSBaseballScout]

Collin Hernandez ('29, SC)⬇️

Relaxed semi-open stance w/ small LL, Keeps BP level, Hands Fire through the zone, Sends this one to the RCF gap for a 2B.

#CLTFall | @sox_carolina

👤 https://t.co/iHGcHX5pFY

[Duke Clinical Research Institute @DCRINews]

The DCRI will lead the SYMPHONY Consortium, a national network testing AI agents for heart failure care across diverse health systems and rural sites. The goal: determine whether these tools are safe, effective, equitable, and scalable. https://t.co/9CTvLVxNp3
@american_heart

[Duke Clinical Research Institute @DCRINews]

Ahead of Beyond the Endpoint’s Sept. 9 episode reflecting on 30 years of the DCRI, founder Robert Califf and current executive director Adrian Hernandez play a game of "what kind of bread are you?" Multigrain, sourdough, ciabatta...watch to find out who's who. 🍞

[Adrian “WE NEED RCTS!” Hernandez @texhern]

So humbling and so true!

And why it’s important to have the definitive trials.

While #ai can do many things #hi (human intelligence) means testing our best hypotheses…especially when we’re aiming to improve health outcomes.

[Gregg Fonarow MD @gcfmd]

🧪➡️💊 Going from discovery ➡️ improved CV outcomes in RCTs is very very challenging

20+ once-promising CV targets, oral GP IIb/IIIa, CB1, PDE-3, niacin, Lp-PLA2, aliskiren, all failed or harmed in major CV outcome trials ❌📉

A validated mechanism ≠ a proven therapy ❤️🔬

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Important point…. Different molecules can act differently

Will be interesting to see how all of the data unfolds

[John Maraganore 🇺🇸🇬🇷🇺🇦 @JMaraganore]

WOW!

Hopefully this quote bodes well for other efforts: “The findings provide important new evidence on the relationship between Lp(a) lowering and cardiovascular outcomes.”

And remember, ASOs are NOT RNAi! https://t.co/vtwRiMZij7

[John Maraganore 🇺🇸🇬🇷🇺🇦 @JMaraganore]

WOW!

Hopefully this quote bodes well for other efforts: “The findings provide important new evidence on the relationship between Lp(a) lowering and cardiovascular outcomes.”

And remember, ASOs are NOT RNAi! https://t.co/vtwRiMZij7

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Wow!

Mother Nature is always tricky!

#clinical trial randomization > Mendelian randomization

[C. Michael Gibson MD @CMichaelGibson]

Breaking and MASSIVE:
Lowering Lp(a) with #pelacarsen in patients with elevated Lp(a) and heart disease does NOT improve cardiovascular outcomes in Phase 3 trial https://t.co/QrN5I3NNlc

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Congrats @embimd

What a great choice for @NIH !!

[NIH @NIH]

NEWS: Physician-scientist and informatics leader Dr. Peter Embí to helm NIH’s National Library of Medicine.

Read the full story ➡️ https://t.co/IDTqZqLepP

[JAMA @JAMA_current]

💬 Editorial by @JAMAplusTrials Editor in Chief Alison J. Huang, MD, MAS, Thomas G. Travison, PhD, and JAMA Senior Editor Derek C. Angus, MD, MPH:

#PragmaticTrials are intended to support real-world clinical decision-making, but the term is used inconsistently across studies. A pragmatic orientation may improve the applicability of #ClinicalTrials to routine care, yet it does not justify weaker methods or reduced rigor.

📣 This September’s JAMA+ Trials Theme of the Month examines ongoing confusion and debate in pragmatic trial research, including how eligibility, intervention delivery, outcome assessment, and analysis align with pragmatic goals. Clearer design and reporting may help clinicians and health systems judge whether trial findings are usable in practice.

🔗 https://t.co/9ETPVcbvsr

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Congrats @SusheelKodaliMD

Great choice

[NYU Langone Health @nyulangone]

We’re happy to welcome @SusheelKodaliMD as director of interventional cardiology and our Cardiac Catheterization Laboratory! A world-renowned leader in cardiac care, he's helped advance TAVR and other treatments for complex heart valve conditions: https://t.co/mOsVCzYzGU

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Great choice! Congrats @SVRaoMD

[NYU Langone Health @nyulangone]

We’re pleased to announce that @SVRaoMD has been named director of the Leon H. Charney Division of Cardiology, where he’ll oversee clinical care, research, and education while advancing innovation in cardiovascular medicine.

Learn more about Dr. Rao: https://t.co/CpDdSKr6aA

[C. Michael Gibson MD @CMichaelGibson]

Dr. Marat Fudim and Dr. C. Michael Gibson discuss the MUSIC-HFpEF trial: Data from the first-in-human Phase 1/2a trial demonstrated that single intracoronary infusion of AAV1.SERCA2A was safe and associated with reductions in resting and exercise-induced PCWP in patients with hemodynamically confirmed HFpEF. Watch video here: https://t.co/f5voyekVz0

[Adrian “WE NEED RCTS!” Hernandez @texhern]

@CardioBusiness @nyulangone Congrats @SVRaoMD and Susheel! Well deserved

[NIH Pragmatic Trials Collaboratory @Collaboratory1]

📣 In this week's PCT Grand Rounds, Haider Warraich of @ARPA_H will present “Evaluating Clinical Agentic AI.” Join us! #pctgr

🔗 https://t.co/h0ugxduzFF

[NIH @NIH]

NEWS: Dr. Wendy Weber to serve as director of the National Center for Complementary and Integrative Health.

Read the full story ➡️ https://t.co/aUKzVLGAq1

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Outstanding group of people !
Congrats to all and @gcfmd who has contributed many lifetimes towards improving quality of care and outcomes across the spectrum of heart failure!

[HFSA @HFSA]

Congratulations to the 2026 HFSA Award recipients! 🏆

We're proud to recognize the individuals and teams whose leadership, innovation, research, mentorship & service are advancing heart failure care.

Meet the honorees being recognized at #HFSA2026: https://t.co/YZwqyDwuau

[CardioHealthAlliance @AllianceCardio]

The CardioHealth Alliance is excited to welcome UCLA Health as a new health system collaborator! 🎉UCLA Health’s support will help advance efforts to develop and implement groundbreaking research initiatives aimed at improving cardiometabolic outcomes: https://t.co/PjRDP7bQue

[Adrian “WE NEED RCTS!” Hernandez @texhern]

Celebrating a great start for @manesh_patelMD as @American_Heart President @robmentz @SvatiShah

[Duke Clinical Research Institute @DCRINews]

Congrats to DCRI's Mark Darby, whose stunning Emerald Isle sunrise photo was selected as the latest winner of @WorkingatDuke’s Duke Time Off photo contest! See Mark's photo and learn how Duke faculty and staff can participate: https://t.co/WCScpi2eyK