TEXIMMED2- Freiburg Labs

Translational EXperimental IMmunology MEDicine 2 Freiburg

Labs of
R. Thimme,
M. Hofmann,
C. Neuman-Haefelin,
T. Boettler,
B. Bengsch

We live(r) immunology

[TEXIMMED2- Freiburg Labs @teximmed2]

@druppygill @Uniklinik_Fr @blizard_inst @BartsHepatology Thanks @druppygill for coming and sharing your expertise.

[Gastroenterology @AGA_Gastro]

Exhaustion of CD39-Expressing CD8+ T Cells in #Crohn’s Disease Is Linked to Clinical Outcome https://t.co/IFhGZp54Bh

[TEXIMMED2- Freiburg Labs @teximmed2]

7/7: However, Omicron-breakthrough infections induced superior antibody neutralization against Omicron compared to 4th vaccination.

[TEXIMMED2- Freiburg Labs @teximmed2]

We are very happy to share our latest data on SARS-CoV-2 boost vaccinations & breakthrough infections in @NatureComms - great collaboration with the @MartinSchwemmle Lab!

https://t.co/2d2M7nby6F

Key points:
(1/7)

[TEXIMMED2- Freiburg Labs @teximmed2]

6/7: Breakthrough infections (after 3rd vaccination) also induced a short-lived CD8+ T cell effector response, which was compareable in phenotype and dynamics to a 4th vaccination.

[TEXIMMED2- Freiburg Labs @teximmed2]

5/7: Importantly, this memory pool was already formed after the 2nd vaccine dose and shows limited phenotypic changes after boosting, regardless whether specific memory subsets (TSCM & TCM) or more comprehensive measures to define memory cells (CD127+ & BCL-2) were analyzed.

[TEXIMMED2- Freiburg Labs @teximmed2]

4/7: Further analysis revealed the presence of classical memory cells throughout the effector phase upon boost vaccination, suggesting effector responses are built on top of a stable memory pool.

[TEXIMMED2- Freiburg Labs @teximmed2]

3/7: Phenotypically, the effector responses induced after each vaccination are indistinctive. Importantly, CD8 T cells with high BCL-2 expression were maintained upon boost vaccination.

[TEXIMMED2- Freiburg Labs @teximmed2]

2/7: Spike-specific CD8+ T cells are efficiently activated (CD38+, Ki67+, T-bet high) and expanded by a 3rd mRNA vaccination. This boosting effect lasts approx. 2 months.

[Anna-Maria Globig @AnnaGlobig]

Very happy to see this out in @NatureComms! 🥳🎉
We identify a distinct Tc17 cell population in Crohn’s disease with proinflammatory features linked to disease activity.
Check out the paper here:
https://t.co/SSBLeWASxM

Huge thank you to everyone involved @teximmed2

[TEXIMMED2- Freiburg Labs @teximmed2]

Excited to share our work on T cell exhaustion in Crohn’s disease. @AGA_Gastro @AnnaGlobig @Therealbbengsch

CD39+ CD8 T cells in the blood
are associated with Crohn's activity

⬆️T cell exhaustion 🟰 Crohn's disease activity⬇️

full paper here:
https://t.co/vmLQMR0Ilk

[TEXIMMED2- Freiburg Labs @teximmed2]

Next week, he will pass on his knowledge to the next generation at the @EASLedu School in Freiburg. https://t.co/AMqz1aFNKB

[TEXIMMED2- Freiburg Labs @teximmed2]

Robert Thimme giving the laudatory speech for Martin Rössle who is receiving the @EASLnews Innovation award in hepatology. A true giant in field and the godfather of TIPS.
#ILC2022

[TEXIMMED2- Freiburg Labs @teximmed2]

#liverimmunology high profile session at the #ILC2022 and filled with experts in the audience. Great fun!

[Alexander Ploss @PlossLab]

Very much enjoyed the @TRR179_2 viral #hepatitis conference in @Freiburg. Fantastic presentations by @jschoggins @EJohnWherry @EranElinav @jbaileylab @julie_lucifora @alexandrovteam @MartinSchwemmle @luglilab @teximmed2 and many others. Thanks Robert for your great hospitality!

[TEXIMMED2- Freiburg Labs @teximmed2]

@TheBinderLab @fireskyer @JohannHolzmann @fitterhappierAJ @bertoletti_lab Sicher valide Hypothese, die weiter untersucht gehört. @bertoletti_lab ist exzellent. Sehr gute Arbeiten zur Epitop-Diversität und Immundominanz von SARS-CoV-2 spezifischen T-Zellen auch von @profshanecrotty und @SetteLab vom LJI in San Diego.

[TEXIMMED2- Freiburg Labs @teximmed2]

@druppygill @BritSocGastro @DrPKennedy @Peppa_Group @maini_lab @bertoletti_lab @pallett_lab @blizard_inst @BartsHepatology Congrats Uppy!

[TEXIMMED2- Freiburg Labs @teximmed2]

This is going to be really good! Make sure you do not miss #ILC2022 in London. It's been a loooong time!

[TEXIMMED2- Freiburg Labs @teximmed2]

Once again, congrats Maike Hofmann. This prestigious research award is so very well deserved! 👏 @TRR179_2

[BMFTR @bmftr_bund]

Unsere Staatsministerin Kornelia Haugg mit den Preisträgerinnen und Preisträgern der Heinz Maier-Leibnitz -Preise 2022. Herzlichen Glückwunsch! 🥳

[TEXIMMED2- Freiburg Labs @teximmed2]

@joostphdrenth Thanks all and congrats! Important study for self-monitoring of diet mistakes.
Positive tests in placebo arm due to diet mistakes or specificity of the assay?