Gabriele Cerutti

Postdoctoral Research Scientist @ZuckermanBrain, Columbia University.
Biochemistry/Biophysics/Structural Biology 🔬

[Gabriele Cerutti @theGABcerutti]

(1/6) Excited to share my latest paper published in @MolecularCell ! Combining structural and developmental biology @ZuckermanBrain we investigated the function of the sevenless receptor tyrosine kinase.
https://t.co/vbnj6n5BSA

[Molecular Cell @MolecularCell]

Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase https://t.co/MIMHacWlPz

[Gabriele Cerutti @theGABcerutti]

(6/6) Big thank you to my mentor @lawrenceshapiro @ColumbiaBiochem, Andrew Tomlinson @ColumbiaGenDev, @NatEyeInstitute @SEMC_NYSBC @Frances84469032 @BobGrassucci @zhang_zhening for your support!

[Gabriele Cerutti @theGABcerutti]

(1/6) Excited to share my latest paper published in @MolecularCell ! Combining structural and developmental biology @ZuckermanBrain we investigated the function of the sevenless receptor tyrosine kinase.
https://t.co/vbnj6n5BSA

[Gabriele Cerutti @theGABcerutti]

(5/6) Sevenless belongs to the ROS family of RTKs, which includes the human ROS1 involved in tissue development and non-small cell lung #cancer.

[Francesca Vallese @Frances84469032]

Today I celebrate my first month as Assistant Professor at @asrc_gc . I am not great at making announcements, but I am incredibly grateful for this opportunity and to @OliBClarke for his mentorship that helped me get here. The Vallese Lab is opening its doors! Be prepared 💥

[Gabriele Cerutti @theGABcerutti]

Such an honor to present my latest research at the 4th NYC area Cryo-EM meeting! ✨ A great collaboration between @lawrenceshapiro🔬 and Andrew Tomlinson 🪰 at @ZuckermanBrain

Thanks to the organizers @RieNygaard and @OliBClarke for a fully immersive day in #cryoEM!

[Fitzpatrick Laboratory @FitzpatrickLab]

Excited to share the structural basis of pH-activated #endocytosis by LRP2 using #cryoem now online @CellCellPress:

https://t.co/jue7HiHKx3

Great collaboration with Andrew Beenken @theGABcerutti Jonathan Barasch @ColumbiaKidney @lawrenceshapiro @ZuckermanBrain @ColumbiaBiochem

[Fitzpatrick Laboratory @FitzpatrickLab]

Exciting times in quad 4C @ZuckermanBrain @ColumbiaBiochem!

[Francesca Vallese @Frances84469032]

You were waiting for me ankyrin-1 complex 🤩

[Gabriele Cerutti @theGABcerutti]

@AaronOwji Thanks! That is a possibility but I think the 1-RBD up is just very mobile as we see in 3DVA. Not sure why the preferred orientation though, we haven't seen it with other ligand-free SARS-CoV-2 spikes.

[Gabriele Cerutti @theGABcerutti]

Check out our biorxiv preprint on the #cryoem #structure of SARS-CoV-2 #omicron spike! Our analysis reveals conformational changes by mutations, providing insights into omicron’s extraordinary (and scary) antibody resistance. #COVID19
https://t.co/grqgnbrGh6

[Gabriele Cerutti @theGABcerutti]

Paper out @CellReports! We report the #CryoEM structure of a fascinating antibody that binds to a hydrophobic pocket in #SARSCoV2 spike NTD away from the NTD supersite. The structure explains tolerance to some variants of concern.

[Cell Reports @CellReports]

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain https://t.co/NKtSRu9ywT

[The Nobel Prize @NobelPrize]

Giorgio Parisi, @giorgioparisi – awarded this year’s #NobelPrize in Physics – was born in 1948 in Rome, Italy.

He is a professor at Sapienza University of Rome, @SapienzaRoma, Italy.

https://t.co/6klY6Kj32y

[Structure @Structure_CP]

Check out the article by @theGABcerutti and colleagues from Lawrence Shapiro lab at @Columbia reporting #cryoEM #structures of two potent neutralizing #antibodies that bind to the #SARSCoV2 spike #protein #openaccess https://t.co/7aVreVE2ZR

[Filippo Mancia @pippomancia]

It's a real pleasure for #ManciaLab to be part of this superb international collaborative effort lead by @MoronisLab! Congratulations to all those involved!

[Rosemary Cater, PhD @RosemaryJCater]

1/9 Did you know that your brain has tons of #omega3 fatty acids like DHA in it but can’t make them?

Here @Nature is our #cryoEM structure of MFSD2A that transports DHA across the #BloodBrainBarrier to fuel your brain! 🐠➡️🧠 @pippomancia #ManciaLab https://t.co/crVDJtIKmd

[Filippo Mancia @pippomancia]

#ManciaLab latest in @Nature! Check out our structure of #DHA lysolipid transporter MFSD2A https://t.co/cAVZk3zsI4 - Congrats @RosemaryCater1 & fantastic team of collaborators @columbiaps @WeillCornell @GeorgeKhelashv1 @dukenus @OliBClarke @uazresearch @michaeltmarty @UChicago