Jeremy Clarkson’s Farm show on Amazon is the most radicalizing piece of mainstream media I’ve ever seen
Just one example (bear with me):
Badgers became a protected species in Britain 40+ years ago.
The population has exploded and now frequently transmits tuberculosis to cows
But farmers can’t cull the badger population to protect their cattle because the government still considers them to be endangered
Instead of addressing the root cause, the UK has the most batshit testing regime for cattle
There’s no TB vaccine. So the cattle have to get tested. The vets administering the test have to measure welts on the cows neck. Whether a cow lives or dies comes down to a vet trying to discern 1mm on a caliper (reactive vs non reactive).
If a cow tests positive, the farm (already running on super thin margins) is quarantined and starts hemorrhaging money.
Jeremy Clarkson’s cow (pregnant with twins) has an inconclusive test so it’s separated from the herd. It receives a second inconclusive test so they have to kill it (before it can give birth to the twins).
Now here’s the kicker: the autopsy reveals no sign of TB. It was a healthy cow needlessly killed
So - silver lining the farm should be removed from quarantine, right? WRONG - it’s still under quarantine and has to keep testing and can’t sell its beef
Kafkaesque doesn’t even begin to describe how f’d up it is for British farmers
@alxshp This is not an open source license, it is a proprietary software license. You need to stop larping as members of the FOSS community when you're an existential threat to it.
@jasonfried Fizzy is not open source, it is proprietary software. You need to stop larping as members of the FOSS community when you are an existential threat to it.
@dhh I don't think you understand the meaning of open source software. You advocate for public software development, not free and open source software.
This is exciting...5-MeO-DMT just got FDA breakthrough designation for treatment resistant depression.
193 ppl with moderate-to-severe depression
38 sites
6 countries
Patients received either 12 mg (n=73), 8 mg (n=46), or a low-dose comparator of 0.3 mg (n=74), which served as a placebo control.
Efficacy Findings
+ at day 29 post-dosing, a single 12 mg dose reduced depression scores by 11.1 points (MADRS scale 0-60), compared to a 5.8-point reduction with the low 0.3 mg dose.
+ the 8 mg dose demonstrated equivalent efficacy, suggesting its potential sufficiency for therapeutic benefit.
+ effects of both 12 mg and 8 mg therapeutic doses were statistically significant compared to the low 0.3 mg dose, starting two days after treatment and peaking at 29 days post-treatment.
+ both 12 mg and 8 mg single doses exhibited durable effects, with mean depression score reductions of 10.2 and 10.8 points, respectively. Both were significantly greater than the 5.2-point reduction observed with the low 0.3 mg dose.
Safety Findings
+ 5-MeO-DMT was well tolerated at all doses, with over 99% of adverse effects being mild or moderate and no serious adverse effects reported.
+ dose related increases in nausea, headache, blood pressure, and anxiety suggest the 8 mg dose was better tolerated than the 12 mg dose.
+ no suicide-related safety signals or concerns were observed.
+ most treated patients were deemed ready to go home within 90 minutes of treatment
Findings from the phase 2a open-label study, using 12 mg and 8 mg doses spaced two weeks apart, showed similar results. These included a rapid decrease in depression score by day 2, maximal improvement at day 22, with a durable effect lasting over 12 weeks of follow-up.
@grok@elonmusk Okay let's re-define the scope of this conversation. I would like you to explicitly focus on the implementation security of both options. Which app is more secure?