Basem Al-Shayeb, Ph.D. 🧬

Co-Founder @ Amber Bio ⌬ PhD from @Doudna_lab & BanfieldLab @UCBerkeley🌋🦠👨‍💻🧬⌬Science #ForbesUnder30 ⌬ formerly @NASAAmes, 🇪🇬🇺🇸 ⌬ #crispr #phage #borgs

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)

https://t.co/zA4EyAVHFQ

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

A great day for RNA, and for groundbreaking science performed at biotech companies! #NobelPrize

[The Nobel Prize @NobelPrize]

“Ten years ago I was kicked out and forced to retire.”

Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.

Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.

Listen now:

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

Thanks @Smanski_Lab for the invite! It was wonderful to share some of our work and hear from faculty and students. Till next time!

[Building Better Bugs @Smanski_Lab]

Thanks @themicrobeguy for a great seminar on engineered trans-splicing. Great our alumni crushing it @umncbs

[Building Better Bugs @Smanski_Lab]

Thanks @themicrobeguy for a great seminar on engineered trans-splicing. Great our alumni crushing it @umncbs

[Zak Doric, PhD @zakdoric]

Had a blast interviewing @themicrobeguy at our @SkyDeck_Cal x @a16zBioHealth student mixer last night. From spotting a synthetic biology flyer in undergrad to quickly becoming a trailblazing scientist-entrepreneur in that field -- what a remarkable journey it's been 🚀@UCBerkeley

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

Thanks to @JuliaBauman2 for this neat recap of our recent work! Stay tuned for updates ���

[Julia Bauman @JuliaBauman2]

A potentially high-efficiency alternative to making large genome edits: making large RNA edits via splicing!

Very cool proof-of-concept from @jacobborrajo @Kamyab_J @themicrobeguy & @BlaineyLab in @biorxivpreprint

[CRISPR Medicine @CrisprMedicine]

@MIT @themicrobeguy @jacobborrajo See also thread explaining Splice Editing by Amber Bio co-founder @themicrobeguy:

https://t.co/7XXhY37Qc1

[Forbes @Forbes]

By targeting RNA rather than DNA, Amber Bio aims to treat multiple genetic diseases with fewer safety risks. https://t.co/AT2MnoDFnW

[BioWorld @BioWorld]

Newco news: With $26M in funding, RNA editing firm Amber Bio targets diverse mutations https://t.co/wpC1MmPiyV #biotech #pharma

[CRISPR Medicine @CrisprMedicine]

Latest CRISPR news -> https://t.co/M1hY9QQMNQ

🚀Amber Bio launches with an oversubscribed $26M seed financing round, which will be used to develop RNA-editing therapies for previously undruggable diseases. Co-founded by Basem Al-Shayeb, Ph.D. & Jacob Borrajo, & they are #hiring

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

We're on a mission to develop intrepid new approaches to RNA medicines. Towards commercialization, we’ve announced the launch of Amber Bio this ~AUG~, with funding from visionary teams at @Playground_VC, @a16z, @EliLillyandCo & more. If this work interests you, we're hiring!

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)

https://t.co/zA4EyAVHFQ

[Kamyab Javanmardi, Ph.D. ⚛️ @Kamyab_J]

Excited to share our recent study describing a new gene editing approach capable of extensive multi-kilobase edits. When DNA is giving you problems look into the RNA. Much more to come, so stay tuned. https://t.co/iMz7zahEpI

[Arturo LoAIza-Bonilla, MD MSEd @DrArturoAI]

CRISPR-Cas and Splicing at kilo base level 🤩🤯👨🏻‍🔬👩‍🔬🧬

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

@Dylan_Smock 🙏🙏

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)

https://t.co/zA4EyAVHFQ

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

@l_loeff Thank you, Luuk!

[SheqLab @ShechnerLab]

Beautiful work—potentially a game-changer! Congrats to the whole team!

[Imran S. Haque (@ihaque@{bsky,genomic}.social) @ImranSHaque]

Neat, splice swapping for RNA editing

[Cameron Myhrvold @cambearon]

This is SO COOL. It's like RNA editing on steroids!

[Mark Budde 🦕🏆 @markwbudde]

Cool work! Cas mediated splicing between transcripts!

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

@markwbudde Thank you Mark! Our team ❤️s primordium and your full plasmid seq that helped make this happen

[Dipa Sashital @dsashital]

CRISPR and splicing together at last! Congrats @themicrobeguy !