“Well his name was Folarin Balogun, that’s a mouthful isn’t it? And they gave him a red card. Very unfair. Very nasty. So I called up FIFA and I said ‘FIFA you better give us our guy back’ and they did. And they did it so fast it’d make your head spin. But it turns out he’s an anchor baby so we’re gonna deport him after the World Cup. We have to do it.”
The market seems willing to test Tokyo’s resolve once more, weakening the yen toward the 160 mark—a level widely seen as a potential catalyst for renewed FX intervention by the authorities.
#economy#fx#japan#markets
A MUST-READ!
This is probably one of my most important papers where I try to teach how to fish rather than offer fish.
How I Read a Clinical Trial Report?
BG’s primer for Busy Clinicians.
Thank you @JCOOP_ASCO@EthicsdoctorP for the kind invitation. I hope the readers will find this useful.
https://t.co/HJhZlsBpU2
Major life hack: The ability to keep showing up even when the rewards are uncertain. Tolerance for uncertainty is the most valuable human trait. The one who can tolerate the most uncertainty is the one who will eventually win.
The upper middle class is caught in a trap, and many of them don’t realize it.
The houses are getting smaller, the lounges more crowded, and the schools pricier.
My latest on how the upper middle class is paying more and getting less: https://t.co/biMiQDMFb0
Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file.
There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it).
Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states.
The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement).
Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.
Congrats India on winning the ICC Men's T20 World Cup! chose the wrong game to go watch:) what a stadium and atmosphere. Well played to the other semi finalists, SA, Eng and Nz!! Also so exciting to see the game expand to so many countries and congrats to ICC for a great tournament!
Black children in Mississippi are now performing better in reading and math than black children in New York and California-- despite having much higher rates of poverty and spending much less per student.
And the secret was simply not allowing children to move up a grade level unless they can read proficiently.
It turns out that when education is prioritized over woke ideology, the outcomes for our kids are better.