Multi-Neuromodulatory fingerprints of an adaptive cognitive state: Cognitive engagement was predicted by joint GABA & ACh/Choline in PFC; by Dopamine & Cholinergic changes in striatum. Glutamate & ACh correlated across states. Kudos to team + Dr Pawliszyn https://t.co/ZixWi7y7g0
2/2 Abilities of inhibitory control, WM updating, and shifting distinguished cognitive phenotypes in NHP's; expl. factor analysis suggested 1) WM updating 2) Shifting/Learning, and 3+4) inhibitory control of interference from external vs internal sources are 4 sep. cogn. factors.
1/2 New paper supporting a 4-factor model of Executive Functions in nonhuman primates (NHPs) using a multi-task assessment approach. NHPs show consistent cognitive phenotypes: A first step quantifying the cognitive architecture in NHP https://t.co/RyPb4zAsew
New IN review covering eTypes, mTypes and comp. motifs of prefrontal interneurons - @KiaBanaie et al. (2026) Prefrontal Cortex Interneurons and their Contributions to Attention, Working Memory, and Adaptive Behavior. Progress in Neurobiology, https://t.co/4PwKUzjEE5
Now out - we show that PV and SOM inhibitory interneurons contribute synergistically to generate cortical oscillations at various frequencies (from gamma down to beta/alpha) and control network stability... https://t.co/5IGtgoZJKK - with Farzin Tahvili and Matteo Di Volo - 1/3
🚀 🚀Preprint out now on bioRxiv!
“KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking”
Brings geometry-free, per-neuron drift correction, without uniform movement assumptions in large-scale recordings.
🔗https://t.co/FDDfOWixvl
👇Code + docs
Notable: mental re-ordering (swapping) was more likely with better learning the initial sequence (=memory) (otherwise NHPs keep using serial chaining strategy) and correlates with working memory performance - kudos to Xuan, Adam and Seema for pulling this off ! 2 / 2
New paper shows how nonhuman primates learn (5-) object sequences and use context cues to mentally re-order objects within a learned sequence – showing that NHPs form non-spatial cognitive maps 1 / 2 https://t.co/jmdz6xeBJs
Overall, the effects suggests that stimulation induced uncertainty in the ACC (with few exceptions) and in striatum boosted feature-specific credit assignment and updating of attentional priorities. Kudos to Louis, Kia, Charlie, Adam and Paul for pulling this off.
Modeling suggests stimulation improved/impaired directed exploration/information gathering of relevant objects and the updating of feature values. Recordings showed ACC firing tracked feature uncertainty and error history, while striatum tracked stronger feature values of objects
New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron https://t.co/nEsn6HXW9j
1/2
What makes memories last—dynamic ensembles or static synapses? | The Transmitter: Neuroscience News and… https://t.co/mqcd0KOD5a Thanks to @JasonSynaptic for organizing!
Excited to share that the latest @perpl_lab paper is published in @CellReports. We describe the dynamics of superficial and deep CA1 pyramidal cells and identified putative groups of inhibitory cells in freely moving, thinking, and sleeping macaques. 1/n
@PeterMKaskan @Hiroyuki_O please also send your study/abstract - ACC stim only impaired = Loss-of-Function... but we found an improving spot too... happy to talk/email about it, a good BRAIN conf.!
If you are interested in how the Anterior Cingulate Cortex affects behavior: Brief ACC-stimulation when an object is fixated changes inferring the relevance of that object over other objects, i.e. ACC reduces uncertainty about the objects' value. 1/3
https://t.co/mCkkHC3Svg
Led by Satoka Fujimoto and with @RussBEneuro and @HelenMaybergMD our first paper on the effects of deep brain stimulation in the brain. What’s exciting is that we find it induces white matter remodeling in specific tracts. @SinaiBrain https://t.co/8hgMmlQBfH
The conclusion is the ACC causally meta-adjusts learning strategies during periods of uncertainty to infer which objects to choose/attend/explore for best outcomes.
kudos to @LTreuting44120 and the team with @KiaBanaie to pull this off!! 3/3