Thilo Womelsdorf

[Thilo Womelsdorf @thiwomTO]

Multi-Neuromodulatory fingerprints of an adaptive cognitive state: Cognitive engagement was predicted by joint GABA & ACh/Choline in PFC; by Dopamine & Cholinergic changes in striatum. Glutamate & ACh correlated across states. Kudos to team + Dr Pawliszyn https://t.co/ZixWi7y7g0

[Thilo Womelsdorf @thiwomTO]

2/2 Abilities of inhibitory control, WM updating, and shifting distinguished cognitive phenotypes in NHP's; expl. factor analysis suggested 1) WM updating 2) Shifting/Learning, and 3+4) inhibitory control of interference from external vs internal sources are 4 sep. cogn. factors.

[Thilo Womelsdorf @thiwomTO]

1/2 New paper supporting a 4-factor model of Executive Functions in nonhuman primates (NHPs) using a multi-task assessment approach. NHPs show consistent cognitive phenotypes: A first step quantifying the cognitive architecture in NHP https://t.co/RyPb4zAsew

[Thilo Womelsdorf @thiwomTO]

New IN review covering eTypes, mTypes and comp. motifs of prefrontal interneurons - @KiaBanaie et al. (2026) Prefrontal Cortex Interneurons and their Contributions to Attention, Working Memory, and Adaptive Behavior. Progress in Neurobiology, https://t.co/4PwKUzjEE5

[Martin Vinck @martin_a_vinck]

Now out - we show that PV and SOM inhibitory interneurons contribute synergistically to generate cortical oscillations at various frequencies (from gamma down to beta/alpha) and control network stability... https://t.co/5IGtgoZJKK - with Farzin Tahvili and Matteo Di Volo - 1/3

[Kianoush Banaie Boroujeni @KiaBanaie]

Also check out our website for a detailed guide and overview:

https://t.co/I9plsqjfMe

[Kianoush Banaie Boroujeni @KiaBanaie]

GUI walkthrough & tutorial video here:
https://t.co/ik7wdhQJBB
Code & install instructions on GitHub: https://t.co/gXkHfcZZSd

[Kianoush Banaie Boroujeni @KiaBanaie]

🚀 🚀Preprint out now on bioRxiv!
“KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking”

Brings geometry-free, per-neuron drift correction, without uniform movement assumptions in large-scale recordings.
🔗https://t.co/FDDfOWixvl
👇Code + docs

[Thilo Womelsdorf @thiwomTO]

Notable: mental re-ordering (swapping) was more likely with better learning the initial sequence (=memory) (otherwise NHPs keep using serial chaining strategy) and correlates with working memory performance - kudos to Xuan, Adam and Seema for pulling this off ! 2 / 2

[Thilo Womelsdorf @thiwomTO]

New paper shows how nonhuman primates learn (5-) object sequences and use context cues to mentally re-order objects within a learned sequence – showing that NHPs form non-spatial cognitive maps 1 / 2 https://t.co/jmdz6xeBJs

[Thilo Womelsdorf @thiwomTO]

Overall, the effects suggests that stimulation induced uncertainty in the ACC (with few exceptions) and in striatum boosted feature-specific credit assignment and updating of attentional priorities. Kudos to Louis, Kia, Charlie, Adam and Paul for pulling this off.

[Thilo Womelsdorf @thiwomTO]

Modeling suggests stimulation improved/impaired directed exploration/information gathering of relevant objects and the updating of feature values. Recordings showed ACC firing tracked feature uncertainty and error history, while striatum tracked stronger feature values of objects

[Thilo Womelsdorf @thiwomTO]

New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron https://t.co/nEsn6HXW9j
1/2

[Saman Abbaspoor @SAbbaspoor]

Experience reorganizes content-specific memory traces in macaques 🐒🧠. @perpl_lab @AymanAljishi

https://t.co/TDx7wYbgE0

[Kari Hoffman @perpl_lab]

Humor me: I’m reactivating the latest preprint from the lab (itza “new” trace) 🤓

[Kari Hoffman @perpl_lab]

What makes memories last—dynamic ensembles or static synapses? | The Transmitter: Neuroscience News and… https://t.co/mqcd0KOD5a Thanks to @JasonSynaptic for organizing!

[Saman Abbaspoor @SAbbaspoor]

Excited to share that the latest @perpl_lab paper is published in @CellReports. We describe the dynamics of superficial and deep CA1 pyramidal cells and identified putative groups of inhibitory cells in freely moving, thinking, and sleeping macaques. 1/n

[Thilo Womelsdorf @thiwomTO]

@PeterMKaskan @Hiroyuki_O please also send your study/abstract - ACC stim only impaired = Loss-of-Function... but we found an improving spot too... happy to talk/email about it, a good BRAIN conf.!

[Thilo Womelsdorf @thiwomTO]

If you are interested in how the Anterior Cingulate Cortex affects behavior: Brief ACC-stimulation when an object is fixated changes inferring the relevance of that object over other objects, i.e. ACC reduces uncertainty about the objects' value. 1/3
https://t.co/mCkkHC3Svg

[Rudebeck Lab @RudebeckLab]

Led by Satoka Fujimoto and with @RussBEneuro and @HelenMaybergMD our first paper on the effects of deep brain stimulation in the brain. What’s exciting is that we find it induces white matter remodeling in specific tracts. @SinaiBrain https://t.co/8hgMmlQBfH

[Thilo Womelsdorf @thiwomTO]

The conclusion is the ACC causally meta-adjusts learning strategies during periods of uncertainty to infer which objects to choose/attend/explore for best outcomes.
kudos to @LTreuting44120 and the team with @KiaBanaie to pull this off!! 3/3