Thomas Nguyen

PhD in @sheilateves' lab studying transcriptional regulation. Pokémon Go in my off-time.

[Sheila Teves @sheilateves.bsky.social @sheilateves]

So proud of @thomasfnguyen and co-authors on the publication of this manuscript. Now out in Genetics!

See full paper here! https://t.co/AbIihnokK6

Thank you to the editors of Genetics for effiecient handling, and to the peer reviewers for excellent feedback

[Sheila Teves @sheilateves.bsky.social @sheilateves]

🚨 New Teves Lab Publication Alert! 🚨

Excited to share our latest research published in @RNABiology: "TBP facilitates RNA Polymerase I transcription following mitosis". Read the full article here: https://t.co/T2baqrbi2U

Tweetorial below!

[Sheila Teves @sheilateves.bsky.social @sheilateves]

New preprint from the Teves lab!

We had previously published that TBP is not required for Pol2 transcription in mESCs... What about Pol1? In the preprint below, we try to address precisely this question
1/ https://t.co/4x5DIDTwJy

[Marek Budzynski @MarekBudzynski]

I am excited to let you know that my recent article is now published in Nucleic Acids Research journal and available here: https://t.co/ELX84wHuLz

This is joint work between me and graduate student in @sheilateves lab – Rachel Price.

[Thomas Nguyen @thomasfnguyen]

@enhancer_RNA @eLife @JamesKw18756415 We did not look deeply into changes in transcription initiation patterns like alternative TSS usage, but that would be great to explore!

[Thomas Nguyen @thomasfnguyen]

We are very excited to present our recent work published in @eLife. https://t.co/beJFLrTKDH

Co-authored with @JamesKw18756415, we show that acute depletion of TBP (TATA-box binding protein) in mouse embryonic stem cells (mESCs) has no global effect on RNA Pol II transcription.

[Thomas Nguyen @thomasfnguyen]

@LeoSerebreni @eLife @JamesKw18756415 Thank you! Good question, TRF3 seems to be not present in mESCs.

[Thomas Nguyen @thomasfnguyen]

@TanjaBhuiyan6 @eLife @JamesKw18756415 Thank you! We did not look at BTAF1, but it would be interesting to explore!

[Thomas Nguyen @thomasfnguyen]

Last but definitely not least, the biggest thank you to our outstanding mentor @sheilateves. This work would not have been possible without her constructive feedback, never-ending support, and amazing mentorship.

[Thomas Nguyen @thomasfnguyen]

I would like to thank my amazing co-author @JamesKw18756415 for all the sleepless nights we shared designing and running experiments. I’d also like to thank my labmates, thesis committee, and a big thank you to @dranuliuzozie and the @Lange_Lab for their help with proteomics.

[Sheila Teves @sheilateves.bsky.social @sheilateves]

Teves lab research alert!

Hot off the preprint press:
Our work on revisiting the role of TBP in Pol II transcription is now out on Biorxiv.

The first research work to come out of the Teves lab is led by 2 amazing grad students @JamesKw18756415 and @thomasfnguyen 1/

[Yuan He @YuanHeJHU]

So thrilled to share our #CryoEM structure of the 56-subunit human #Mediator bound #Transcription PIC. Led by fearless @RyanAbdella and @anna_talyzina in a wonderful collaboration with the @TjianDarzacq group. https://t.co/5XqPesiZFs

[Schuh Lab @SchuhLab]

A sperm fuses with an egg to form a zygote. After fertilization, the maternal and paternal chromosomes need to migrate and meet in middle of the zygote.

Our latest work in @NatureComms reveals how this is achieved in mouse zygotes. (1/5)

🔗https://t.co/00rvZEKBva @mpi_bpc