Tisho Jenkut

[Tisho Jenkut @tishojen]

@flpsnd Decided before opening the comments 🥷

[Tisho Jenkut @tishojen]

@flpsnd Left

[Tisho Jenkut @tishojen]

It's 2026. All the frontier labs are overtaking each other in solving the most difficult math problems.

Yet, we still don't understand what causes Parkinson. Or Alzheimer or many other diseases.

Today we're launching models that help predict how to reverse a disease.

[Filip Dousek @fdousek]

We set out to predict how to reverse disease.

Today we’re launching Theorema’s causal disease models:

15 diseases
Trained on data from 100M+ human cells
Found the right cancer drug targets 13.7× more often than chance

Here’s what we’ve built 🧵

[Tisho Jenkut @tishojen]

@CrowElRobot @AI_4_Healthcare @HowToPrompt__ That's reasonable, agree

[Tisho Jenkut @tishojen]

@CrowElRobot @AI_4_Healthcare @HowToPrompt__ The title oversells.

Cortexyme (the company behind this paper) took this to the trial and ran the causal test. Atuzaginstat failed Phase 2/3. Correlations in post-mortem tissue plus mouse amyloid didn't prove causation in humans.

[Tisho Jenkut @tishojen]

Vision is probably the most information-dense sense.

We used to observe the world at all times except for sleep. Say 16-18 hours a day. Now our screen time is 10-12 hours.

how much worse do we understand nature and its laws as a result?

[Tisho Jenkut @tishojen]

@AI_4_Healthcare @HowToPrompt__ This 👆people mistake the two too many times

[Tisho Jenkut @tishojen]

@erinmagennis Thanks! Will be able to share more in coming days 👀

[Tisho Jenkut @tishojen]

@erinmagennis congrats! we're trying to make drug discovery more causal. any best practise on how to apply/get in please?

[Tisho Jenkut @tishojen]

@flpsnd They've added the report ai slop button finally 👀

[Tisho Jenkut @tishojen]

Half an hour of my own writing beat a week of prompting.

Spent a week prompting AI to write copy for me. Couldn't get rid of the weird words and phrases. Even built my own skills trained on real human posts. Still sounded like AI.

Wrote it myself. Half an hour. Way happier.

[Tisho Jenkut @tishojen]

@MakiHacks very solid

[Tisho Jenkut @tishojen]

@saranormous Who's going to watch this?

We can 10x the amount of content produced but we can't 10x the amount actual humans consume.

This is content for the sake of content. Imo the worst motivation for creation.

[Tisho Jenkut @tishojen]

Every Q1 I don't drink or party, eat generally more healthy, exercise almost daily and maintain solid sleep schedule.

Every Q1 around end of January I get sick and find it extremely difficult to get rid of the sickness for weeks.

Random or causation?

[Tisho Jenkut @tishojen]

I wanted to publish a post about defence tech today.

But today is not the day for that.

Today just remember how lucky some of us are.

They're fighting for all of us.

[Tisho Jenkut @tishojen]

Standing in a field outside Kyiv watching a loitering munition hunt a moving target autonomously.

The pilot is 22. The technology is two years old. The pace of progress is incomparable.

[Tisho Jenkut @tishojen]

@TheTrueVanguard HESOYAM

[Tisho Jenkut @tishojen]

Quite remarkble how much impact does slowing down have on one's life.

Speaking slower, slowing down and writing your thoughts under preassure, breathing slower.

Slow seems to be the new speed.

[Tisho Jenkut @tishojen]

@signulll when it comes to what's the hardest i'm always torn between consumer and defence

[Tisho Jenkut @tishojen]

What is the most valuable lesson/insight in the fewest words possible?