Tom

Now on bluesky, same handle

[Tom @tomlau]

Looks like the scientists finally picked which social media platform to move to. Great seeing new and old faces there. See you on bluesky. https://t.co/VZVDx1cwza

[Tom @tomlau]

@JaneAEnglish @UCDProteomics @FemalesInMS @metabolomics A lot of the scientists have moved over the bluesky, you might have better luck there Jane

[Stephan Hacker (inactive account) @StephanHacker2]

Interesting @biorxivpreprint by a team around Jason Thomas and Andrea Byrnes of @Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. https://t.co/Ha5dHJ2Yfq

[Patrick Hsu @pdhsu]

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

[philip lewis @Phil_Lewis_]

New Orleans students Ne’Kiya Jackson and Calcea Johnson, credited with solving the Pythagorean theorem using trigonometry, have discovered nine more solutions to the problem

https://t.co/2p7L9r1PUV

[Tom @tomlau]

More fantastic talks on Day 2 of Structural Proteomics. Love the multidiscplinary aspect. That said, there’s enough mass spectrometrists that all the “and amazingly the antibody worked” jokes have landed. #SSP2024

[Simon Duerr @simonduerr]

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https://t.co/qYzIsbr0TH

[Tom @tomlau]

Twitter can leave me pretty jaded these days but things like #SfNPigeon are what keep me coming back

[Brian Liau @brian_b_liau]

We all have our scientific role models. I’m so lucky that mine was my own mom. 1st-generation & running a lab while raising two boys, she overcame many barriers, to say the least. After 45 years of discoveries @MIT, I hope you enjoy retirement! https://t.co/pRY8Egb6cL

[Paul Novosad @paulnovosad]

What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too?

And why should we care? A 🧵 on our paper on the Nobel Laureates.

A teaser: the income distribution of the laureates' fathers.1/N

[Tom @tomlau]

@AmandaLSmythers All star team! Congrats

[Urban Cycling Institute 🚲  @fietsprofessor]

POV: working in the field of sustainable mobility.

[Tom @tomlau]

@jake4somerville FYI your linktree to "support your campaign" goes to a 404.

[Tom @tomlau]

@brian_b_liau @liaulab Congrats Brian. Hopefully we'll get to catch up again at this years chembio in the hub

[Tom @tomlau]

@SAMyers_lab Wait till they hear what percentage of RNA sequencing experiments use single cell...

[Tom @tomlau]

Most biologists, "I wish proteomics was cheaper, faster, more robust, had universal standards, could be done by someone without a mass spec PhD".
Proteomics vendors and facilities, "Can I offer you some single cell proteomics? It's like what you wanted but the opposite"

[Tom @tomlau]

@brian_b_liau @proteinnns @clee_bio @Malvina_Pap @hansen_lab @liaulab Really nice paper Brian. Congrats to everyone on the team

[Brian Liau @brian_b_liau]

How do intrinsically disordered regions (IDRs) regulate protein function? Today in @MolecularCell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6)
https://t.co/XRNw9Q4V7U

[Tom @tomlau]

Love this idea! Two of my favourite labs working together. Really useful application where @Keribackus 's chemoproteomics and @nesvilab's Fragpipe modification search enables not only target ID but site ID.

[Keriann Backus @Keribackus]

Thrilled to share our groups' new SEE-CITE photoaffinity labeling methodology where we installed a silyl cleavable linker between the diazirine and MOI to enable head-to-head interactomics. Spearheaded by Sho Takechi and Chau Ngo and now up on @ChemRxiv https://t.co/qBnz94l7Gs

[Tom @tomlau]

@jake4somerville @MattForWard1 @MbahCouncilor @BenForWard3 Thanks for the very reasonable response. I hope the other 10 votes feel the same!

[Tom @tomlau]

Someone took the time to mine and graph the somerville police traffic enforcement changes over the year. A fascinating read. https://t.co/niRGA4bkYG @jake4somerville @MattForWard1 @MbahCouncilor @BenForWard3