Looks like the scientists finally picked which social media platform to move to. Great seeing new and old faces there. See you on bluesky. https://t.co/VZVDx1cwza
Interesting @biorxivpreprint by a team around Jason Thomas and Andrea Byrnes of @Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. https://t.co/Ha5dHJ2Yfq
🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work
New Orleans students Ne’Kiya Jackson and Calcea Johnson, credited with solving the Pythagorean theorem using trigonometry, have discovered nine more solutions to the problem
https://t.co/2p7L9r1PUV
More fantastic talks on Day 2 of Structural Proteomics. Love the multidiscplinary aspect. That said, there’s enough mass spectrometrists that all the “and amazingly the antibody worked” jokes have landed. #SSP2024
We all have our scientific role models. I’m so lucky that mine was my own mom. 1st-generation & running a lab while raising two boys, she overcame many barriers, to say the least. After 45 years of discoveries @MIT, I hope you enjoy retirement! https://t.co/pRY8Egb6cL
What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too?
And why should we care? A 🧵 on our paper on the Nobel Laureates.
A teaser: the income distribution of the laureates' fathers.1/N
Most biologists, "I wish proteomics was cheaper, faster, more robust, had universal standards, could be done by someone without a mass spec PhD".
Proteomics vendors and facilities, "Can I offer you some single cell proteomics? It's like what you wanted but the opposite"
How do intrinsically disordered regions (IDRs) regulate protein function? Today in @MolecularCell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6)
https://t.co/XRNw9Q4V7U
Love this idea! Two of my favourite labs working together. Really useful application where @Keribackus 's chemoproteomics and @nesvilab's Fragpipe modification search enables not only target ID but site ID.
Thrilled to share our groups' new SEE-CITE photoaffinity labeling methodology where we installed a silyl cleavable linker between the diazirine and MOI to enable head-to-head interactomics. Spearheaded by Sho Takechi and Chau Ngo and now up on @ChemRxiv https://t.co/qBnz94l7Gs
Someone took the time to mine and graph the somerville police traffic enforcement changes over the year. A fascinating read. https://t.co/niRGA4bkYG @jake4somerville @MattForWard1 @MbahCouncilor@BenForWard3