₿itcoinball⚡️

#bitcoin

[海无方 @vansvoler]

https://t.co/qillFYZYkX

[₿itcoinball⚡️ @tradermtl]

@0xVishnya @Plasma Need this card definitely, and need your code

[Jeff Swanson @theswansjr]

"Bitcoin isn't backed by anything."
Let me stop you right there.

Bitcoin is backed by energy. Real energy. Kilowatts. Heat. Physics.
The kind of backing you can't print, fake, or vote into existence at an emergency Fed meeting.

Every block mined is a thermodynamic proof of work. Not a promise. Not a policy. Proof.

The issuance schedule has never been amended by a committee. Not once. Not ever. Because there is no committee.
There's just math. Cold, indifferent, and immune to political theater.

The network is secured by more raw computing power than anything humanity has ever built. Hundreds of exahashes per second standing guard. Every single day.

Now let's talk about what is backed by nothing.
The dollar.

It's is backed by confidence. Specifically, confidence in the institution that printed $6 trillion in two years while telling you 3% inflation was healthy and you should be grateful for the soft landing.

In the same people who can't pass an audit.
Who fund wars with a credit card.
Who promise solvency while sitting on $39 trillion in debt and accelerating.

"Backed by nothing" isn't an attack on Bitcoin.
It's a confession about the dollar.

Follow if you're serious about building wealth they can't print away.

[Kaan Arven @kaanarven]

Gerçek ralli kimsenin konforlu olmadığı yerden başlar.

Bitcoin’de herkes 80.000 ve üzerini konuşuyor ama aşağıda hâlâ alınmamış ciddi bir likidite var.

67.000 bölgesindeki CME gap bu işin ana parçası. Bu tarz alanlar temizlenmeden gelen yükselişler genelde sürdürülebilir olmaz.

Orası alındığında piyasa hem yakıt toplar hem de sonraki hareket çok daha sağlıklı olur.

[paracelsus @dogalmaxx]

Ana akım diyet ve fitness dünyası, günümüzde otofajiyi (hücrenin kendi kendini yemesi/sindirmesi) aralıklı oruçla, açlıkla veya çeşitli takviyelerle tetiklenmesi gereken mucizevi bir gençleşme ve arınma yöntemi olarak pazarlasa da durum tam tersidir.

Otofajiyi aç kalarak veya ++

[NickSung @NickSung2017]

蒸馏Serenity @aleabitoreddit 已完成第一版，结论：
当前可跟单 $LPK，当前不可立马追高 $SIVE

[GP Q @argosaki]

🚨 IMPOSSIBLE JUST BECAME REAL IN REGENERATIVE ORTHOPEDICS:

Scientists just supercharged cartilage repair by amplifying mitochondria 854x — turning exhausted joint cells into collagen powerhouses that rebuild full load-bearing cartilage in animal OA models in weeks! 🦵🔬

Chondrocytes in arthritic joints have almost zero mitochondria → no energy for collagen/proteoglycan repair.

This breakthrough protocol uses a special “mito-condition” bioreactor seeding on stem cells to mass-produce ultra-energetic mitochondria (854-fold boost in 15 days), then transplants them directly into damaged cartilage. Result?
Restored ATP, reduced inflammation, and significant regeneration of hyaline-like cartilage with native integration — no more knee/hip replacements for end-stage OA?
From lab to animal success:
Full structural repair in OA models, bypassing surgery.
Human clinical trials slated for late 2026.
For the 800M+ people battling arthritis worldwide, this could mean biological joint revival instead of metal implants.
Mind-blown? 🤯
RT if you’d trade surgery for this energy-boost therapy! ❤️
#CartilageRegeneration #OsteoarthritisCure #MitochondriaTherapy #RegenerativeMedicine #JointRepair
Verified sources for the 854x mitochondrial amplification & cartilage regeneration breakthrough (Zhejiang University, published March 2025 in Bone Research):
• Official EurekAlert/News Release (March 31, 2025): https://t.co/Dv37c65T4L
(Details the 854-fold increase via “mito-condition” medium, stem cell-based “mitochondria factory,” superior energy output, and accelerated cartilage regeneration in OA animal models)
• Full peer-reviewed paper (Bone Research, 2025): https://t.co/0hvSQz6Q6H
(Technical on organelle-tuning, AMPK pathway activation, 854x yield calculation over passages, in vitro ATP boosts in OA chondrocytes, and in vivo mitotherapy showing significant cartilage repair over 12 weeks in mouse OA models)
• PMC full-text/open access: https://t.co/hFH3oIbuoQ
(Figures on mitochondrial yield, function, and therapeutic effects in OA chondrocytes/animal models)

Explainer on mitochondrial therapy for cartilage: “New Method Creates 854x More Mitochondria for Cartilage Regeneration” (overview with graphics of the process)
https://t.co/fy9jl9LJox
For those who are interested:
search “854x mitochondria cartilage regeneration” for latest; one popular:
https://t.co/Wo8EoEZssj ]
(Note: Direct lab videos are embedded in university/news pages above—check EurekAlert or Nature .
• https://t.co/yt0TU4jmuF [relevant: search “mitochondria osteoarthritis regeneration” for high-view reactions/explainers from med channels]
• General high-engagement: https://t.co/hCLLc0wC7d (adapt from searches; concepts shown via animations of mito transfer boosting chondrocyte energy)

All facts verified from primary sources—no exaggeration.

Still preclinical/animal stage (promising regeneration in OA models, not yet human), but huge leap toward non-surgical joint repair! 🚀

[波波 Lucy @BoboLucyWisdom]

https://t.co/rTdwYuoIAH

[🌹MIDNIGHT🌹ROSE🌹 @369Jessica369]

椰子油本身并非直接“抗菌神器”，真正起效的关键在于：
你的唾液椰子油富含月桂酸（lauric acid，约占50%），这是一种中链脂肪酸。当它进入口腔，与唾液中的酶反应后，会转化为单月桂酸甘油酯（monolaurin）——这才是真正具有强效抗菌作用的化合物。它能破坏细菌细胞膜，导致有害菌死亡。
科学与实践中最常被提到的潜在益处（结合现有小型研究与使用者反馈）：减少牙龈炎症、出血与肿胀，通过“拉出”方式清除舌苔、死皮细胞与部分细菌生物膜自然改善口气（减少挥发性硫化物）辅助控制牙菌斑积累，轻度美白效果（主要是去除表面污渍，而非改变牙本质颜色）

���无法取代刷牙+牙线，但作为日常口腔护理的优质补充，很多人反馈整体口腔舒适度明显提升。
油漱口过程中实际“拉出”的东西：细菌形成的粘性生物膜（plaque的前体）
舌面与口腔黏膜的死细胞
嵌在牙龈沟里的食物残渣与毒素
漱动过程产生乳化作用，把这些废物“捆绑”在油中，一起吐出。
最佳实践时机：
早晨起床后第一件事（空腹），因为夜间细菌繁殖最多，口腔pH值偏酸性，此时效果最显著。

标准操作指南：
用量：1汤匙（约15ml）优质冷榨椰子油（固态或液态都行）
方法：轻轻含在嘴里，来回漱动，不要用力漱或吞咽
时长：理想10–15分钟，新手可从5分钟开始，逐步增加
频率：每天1–2次

结束后正确清理（超级重要！）：吐到垃圾桶或纸巾里（千万别吐水槽！椰子油遇冷会凝固，容易堵管道）
用温盐水（½茶匙海盐+一杯温水）彻底漱口1–2次，清除残油并舒缓牙龈，正常刷牙+使用牙线

大多数人可见的变化时间线（基于使用者报告与部分研究）：
3–7天：牙龈出血明显减少，口气改善
2–4周：牙龈红肿消退，舌苔变薄，整体清爽感增强

其他可选油（如果不喜欢椰子味）：芝麻油（传统阿育吠陀首选，温和且有研究支持）葵花籽油（中性口感，价格亲民）但椰子油因月桂酸含量最高，通常被认为抗菌潜���最强。

常见疑问解答：
有补牙/牙冠/种植牙能做吗？
可以，非常温和，不会损伤修复体或种植体。
坚持不到10分钟怎么办？
从3–5分钟开始就好，贵在坚持而非一次完美。每天积累的效果更重要。
油漱完还要刷牙吗？
必须！油漱是“加分项”，不是替代品。结束后照常刷牙+牙线。 这项实践已有数千年历史（源自阿育吠陀），至今仍有很多人每天坚持。科学证据目前仍属“有限但有积极信号”（如减少菌斑、类似某些漱口水的抑制效果），但安全性高、副作用极少，值得作为日常口腔护理的自然辅助尝试。
一位女士牙龈严重感染，牙医开抗生素。我建议她改成一天三次椰子油漱口。一周后她发邮件：牙龈完全好了！含一勺椰子油在嘴里，轻轻漱动10���→休息10秒，循环10分钟。
为什么叫“oil pulling”？
因为它像“拉”一样，把舌下腺体、血管、甚至部分鼻窦的废物拉出来。
[注意事项] 吐到垃圾桶，别吐水槽（会凝固堵管）。
之后用水漱几次。[原理] 椰子油碰到口腔细菌后，会变成抗菌状态，能杀灭有害病原体。

[Parker @TheOtherParker_]

This was the highest volume day on $IBIT, ever, by a factor of nearly 2x, trading $10.7B today. Additionally, roughly $900M in options premiums were traded today, also the highest ever for IBIT. Given these facts and the way $BTC and $SOL traded down in lockstep today (normally SOL trades with beta) + the relatively lower liquidations on CeFi exchanges, this leads me to believe that the nexus of the problem lies with a large IBIT holder. IBIT has become the #1 venue for BTC options trading, so my guess is that a hedge fund trading IBIT options is the culprit.

If you look at the 13F filings for IBIT (I like whalewisdom dot com), you'll find a number of interesting names that have the majority of their fund in IBIT. In fact, there are a few in there (not naming names) that have 100% of their fund in IBIT, which likely means no cross margin. In fact, the biggest reason to set up a fund to hold a single asset would be to isolate margin, so that if the trade blew up, the brokers wouldn't have claim to any other assets.

Interestingly, most of these giant, single asset funds are based in HK.

We know that Asian traders, particularly in China, have been deeply involved in the Silver and Gold trade. Silver was down 20% today, which was the 2nd largest 1 day move in a very long time (largest on Jan 30). We also know that the JPY carry trade has been unwinding at an increasingly rapid pace.

This leads me to think that the culprit for the IBIT blowup today was 1 or more HK-based non-crypto hedge funds. As @FranklinBi pointed out, the fund(s) being non-crypto would explain why no one sniffed them out. They would likely have few/no crypto counterparties, meaning complete isolation from CT.

The last small piece of evidence I have is that I personally know a number of HK-based hedge funds that are holders of $DFDV, which had the worst single down day ever, with a meaningful mNAV decline. The mNAV had been holding steady surprisingly well throughout this pull back until today. One of these fund(s) could have been connected to the IBIT culprit, as I highly doubt a fund taking that large of a position in IBIT and using a single entity structure would only have the one fund.

Now, I could easily see how the fund(s) could have been running a levered options trade on IBIT (think way OTM calls = ultra high gamma) with borrowed capital in JPY. Oct 10th could very well have blown a hole in their balance sheet, that they tried to win back by adding leverage waiting for the "obvious" rebound. As that led to increased losses, coupled with increased funding costs in JPY, I could see how the fund(s) would have gotten more desperate and hopped on the Silver trade. When that blew up, things got dire and this last push in BTC finished them off.

I have no hard evidence here, just some hunches and bread crumbs, but it does seem very plausible. Let's see if some more concrete evidence floats to the surface here soon. The smoking gun will be a large fund fitting this profile filing a 13F showing a giant IBIT holding going to zero. Unfortunately, if a fund had their IBIT position liquidated today, they wouldn't have to disclose the position change until 45 days after the quarter end, so we'd be looking at mid May for the smoking gun from 13F filings most likely.

Hopefully some of you out there with too much time on your hands this weekend can snoop around more. My guess is that word will start to get out, because something of this size is just too hard to hide. Additionally, if the broker was not able to liquidate the fund in time, the broker may have a hole in their balance sheet, which would be even more difficult to hide.

[Voltage ⚡ @voltage_cloud]

$1,000,000 was settled over the Lightning Network. On January 28th history was made.

We just powered the first publicly reported $1M Lightning transaction between @SD_Markets and @krakenfx in .47 seconds.

The future of institutional Bitcoin settlement is here.

Lightning got boxed in early. "It's for micropayments." That narrative stuck, but it was only ever part of the story.

Lightning is settling million-dollar transactions today. It's time the world sees this network for what it actually is.

This is only the beginning.

Bitcoin moving at the speed it was meant to.

Powered by @voltage_cloud

[Jason R. Williams, MD, DABR @jasonwilliamsmd]

We've spent 50 years trying to kill cancer cells. What if the answer was never to kill them but to remind them who they are?

Cancer cells aren't foreign invaders. They're your own cells that lost their identity. They stopped differentiating, stopped maturing, and started growing without limits. Cancer doesn't create anything new. It hijacks normal biology.

Researchers at KAIST in South Korea identified three master regulators, MYB, HDAC2, and FOXA2, keeping colon cancer cells locked in a malignant state. When they silenced all three? The cancer cells differentiated back into normal, healthy tissue. MYC and WNT pathways shut down. In mice, tumors shrank significantly.

No chemo. No radiation. Just reprogramming.

Here's what most people will miss: HDAC2 is a histone deacetylase. It compacts DNA and silences tumor suppressor genes. We already use HDAC inhibitors in our protocols. This isn't new to us. But it's powerful validation.

Cancer and aging are the same problem. Cells that no longer serve the body but learned to hijack the immune system to survive. The answer isn't bigger bombs. It's restoration.

Still preclinical. But the direction is exactly right. Kudos to the @kaistpr team. 👏

[Wealth Theory @Wealth_Theory]

Win or lose, Saylor swung for the fences.

The world presented him with an opportunity to create and control the largest Bitcoin stack in the world and he grabbed it with both hands.

That is gangster material. Trolls, investors, bag holders, they are all nothing compared to him.

When the dust settles and Bitcoin succeeds, which it most likely will, he will have cemented his name into history in a way that very few will ever be able to do.

He will go down as the tardiest OG. The last one to turn back the clock 10 years late and pull up beside the first whales.

Let the games play out, and I hope he rides this bronc out.

[Chaitanya Jain @CJ_Bitcoin]

Strong hands create bull markets.
Bull markets create weak hands.
Weak hands create bear markets.
Bear markets create strong hands. $BTC

[Dr.Wang @HotmailfromSH]

「医药快讯：每日一滴 30分钟改善老花眼！“复方滴眼液”获批FDA」

2026年1月28日，Tenpoint Therapeutics公司宣布，美国食品药品监督管理局（FDA）已批准YUVEZZ（carbachol and brimonidine tartrate ophthalmic solution，2.75%/0.1%，卡巴胆碱和酒石酸溴莫尼定滴眼液） 上市，用于治疗成人老花眼（Presbyopia）。

作为首个也是目前唯一一个用于治疗成人老花眼的双效复方滴眼液。 与此同时，该公司完成了 2.35 亿美元的融资，以支持该药物在美国的上市。YUVEZZI预计将于2026年第二季度在美国全面上市。

老花眼是一种近距离视力逐渐下降的现象，通常在45岁左右开始出现，并显著影响老年人的生活质量和视觉功能。老花眼是衰老过程中自然且不可避免的一部分，全球约有20亿人受到影响。老花眼会削弱晶状体改变形状、聚焦近处物体的能力，也会使人难以适应不同水平的环境光照，尤其在昏暗或低对比度条件下更为明显。

YUVEZZI滴眼液此前名为BRIMOCHOL PF，是一种固定剂量复方制剂，由胆碱能激动剂卡巴胆碱和α-肾上腺素能受体激动剂酒石酸溴莫尼定组成。两种药物的联合作用可导致瞳孔缩小，产生针孔效应，从而改善老花眼患者的近视力和景深。

卡巴胆碱于1972年以爱尔康公司Miostat的品牌上市，用于白内障手术中散瞳。酒石酸溴莫尼定于1996年由艾尔建公司作为眼压升高眼药水上市，最近由博士伦公司以Lumify的品牌上市，用于缓解眼部发红。

根据产品标签，YUVEZZI以单剂量小瓶包装，每瓶含卡巴胆碱27.5mg/mL和酒石酸溴莫尼定1mg/mL；一瓶可用于双眼。YUVEZZI的推荐剂量为每日一次，每次每眼滴入1滴。

该批准基于两项3期临床试验的数据，这两项试验纳入了45至80岁的老花眼患者。在BRIO I试验（https://t.co/JPVALiyy3R注册号：NCT05270863）中，182名受试者被随机分配，每次就诊时每只眼睛滴入一滴YUVEZZI、卡巴胆碱或酒石酸溴莫尼定，两次治疗之间至少间隔3天。在BRIO II试验（https://t.co/JPVALiyy3R注册号：NCT05135286）中，436名受试者被随机分配，每只眼睛滴入一滴YUVEZZI(n=218)或赋形剂(n=218)。

两项试验的主要终点均为：在弱光条件下，双眼裸眼近视力较基线提高3行（15个字母）或以上，且双眼裸眼远视力未下降1行（5个字母）或以上的患者比例。

使用YUVEZZI最常见的不良反应包括滴眼后眼痛、视力障碍、滴眼后眼刺激和头痛。处方信息中还包含有关视力模糊、视网膜脱离风险、虹膜炎和血管功能不全加重的警告和注意事项。

[Jeff Booth ⚡️ @JeffBooth]

🧵 The cost of everything technology touches is falling toward zero. Yet, we're told prices should rise. Why? Let's dig into the disconnect between tech-driven deflation and our inflationary monetary system. 👇

[向阳乔木 @vista8]

朋友说这个是这几年最让他震撼的开源产品之一。

比Claude Skill还厉害，应该是下一个大趋势。

地址见评论区

[Ron Sovereignty Swanson⚡️🗝️ @RonSwanonson]

Bitcoin doesn’t really have a “price”

The general public sees it as a stock/investment so we fell into saying “price” to make it easy

Bitcoin is money though, and money has no price. It has an exchange rate

You wouldn’t say “what is the price of a peso” a

[Dylan LeClair @DylanLeClair]

Strategy bought an eye-watering $3.38B of BTC over the past two weeks ($1.25B + $2.13B). Plenty of takes on these moves, but I want to provide some color on what they're doing to the capital structure, which I find to be especially notable.

Firstly, STRC is obviously having its moment in the sun. $119M two weeks ago, $294M this past week—all while STRC stays pinned within 1% of face value.

This $STRC issuance has been in tandem with a large amount of $MSTR ATM . What does this mean, and is this accretive for shareholders?

Most MSTR was sold between 1.0x-1.10x mNAV. This is accretive in net asset terms, however with market cap below the value of BTC holdings, in isolation, it would be negative to BTC/share. However, Saylor is intelligently pairing the MSTR ATM with the STRC ATM. STRC was ~14% the size of MSTR issuance over this period. In BTC per fully-diluted share terms, despite selling of common with BTC below market cap value (while indeed above 1.0x in enterprise value terms), BTC per fully diluted common shares increased over the past two weeks —up 0.4% on the year. So, indeed accretive, but in my view, the bigger story is the focus on deleveraging the convertible bonds to focus on attaining "amplification" through prefs instead.

If we assume constant 92K BTC for consistency, from the start of the year to today:

Converts (less USD) as % of BTC: 9.67% → 9.18%
Prefs (less USD) as % of BTC: 9.19% → 9.36%

Strategy has flipped its outstanding convertible debt with notional prefs, which of course never come due in principal. In just one year.

Why is this being done? Strategy's team has made clear they see the perpetual pref (dubbed "digital credit") as the big idea. The fact that prefs can IPO, with ATMs attached, with no maturity cliff speaks for itself.

But I believe there's an additional motivation potentially: minimizing the gamma effect convertible debt has on the credit spreads of the prefs.

If you correctly view the convertible bonds as debt + an equity call option, at $400 MSTR the weighted delta on the converts was approximately 73%. The market effectively viewed Strategy as having ~$2.18B of effective debt with ~$6.06B that would become equity. This is rough back-of-napkin math, but you can use Black-Scholes to input the convertible bond strikes and first put dates, you can approximate a delta for each bond. In aggregate, you get a weighted average delta.

So yes, while technically $8.2B of debt has been outstanding for almost a year, the market doesn't
treat this as 100% debt—it probabilistically moves with MSTR stock price.

When BTC fell sharply in November and MSTR (as well as all other BTC proxies) followed, the stock price falling essentially partially 'de-equitized' the converts. A move from $400 to $150 is sort of like ~$2.5B more debt becoming senior to the prefs. The delta of the converts—their sensitivity to MSTR price—changed. This change in delta is called gamma.

The point here is that it wasn't necessarily just BTC NAV itself contracting that changed the profile of the prefs in the eyes of some credit investors. It was BTC price moving MSTR price, which impacted the likelihood of conversion of the converts, which impacted the assumed senior liabilities above the prefs.

With the massive purchases in recent weeks, it's clear that Strategy is diligently deleveraging the converts off the balance sheet (relatively), which means the convert gamma will have minimal—and eventually no impact on pref credit spreads.

Having no convertible bonds senior to the prefs should not only improve absolute credit spreads but should diminish credit spread volatility, as the volatility of the size of the assumed senior liabilities above the prefs goes away entirely. This should make prefs like STRC even less volatile, reinforcing the strength and efficiency of the system further.

So to answer the question: yes, this mix of STRC and MSTR issuance is accretive in BTC Yield terms, but I think the bigger story here is the deleveraging of the balance sheet (relatively) of convertible bonds, and it's shifting the focus to pref-style "amplification"—exactly as the MSTR team has stated.

The USD reserve is another recent shift worth noting. It looks to have further dampened credit spread volatility in the prefs by quieting market concerns around dividend coverage and immediate capital raising needs.

Congrats to the Strategy team on having notional prefs surpass converts in just one year.

Wildly impressive.