Trivedi Lab

The research goal of the Trivedi lab is to identify cellular processes and regulatory mechanisms involved in human cardiac and vascular diseases.

[ASCI @the_asci]

Could metformin reduce structural heart disease?

ASCI member @trivedilab & team @UMassChan find epigenetic changes in nuclear DNA aberrantly activate mitochondria, causing aortic valve stenosis, with improvement by metformin in mice: https://t.co/Vf2GmHSsDx

The image shows elevated expression of 8-hydroxy-2'-deoxyguanosine (8OHdG) (green) in vimentin-positive valvular interstitial cells (red) from human stenotic aortic valves, with nuclei (blue).

[Trivedi Lab @trivedilab]

Outstanding collaborative work by Tim Cashman et al - Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin https://t.co/93nk1Y1yUY @UMassChan @umassmemorial @UMass_Medicine @JCI_insight @the_asci @endothelialnews

[Department of Medicine @UMass_Medicine]

Join our collaborative team of investigators! The Division of Cardiovascular Medicine in the Department of Medicine at UMass Chan Medical School is now accepting applications for a tenure-track faculty position. Learn more and apply: https://t.co/HAnuiHq3SY

[Trivedi Lab @trivedilab]

@jonepstein1 @PennMedicine @kevinbmahoney @Penn Congratulations, Jon!

[Trivedi Lab @trivedilab]

Check out a new review series: Lymphatic System in Organ Development, Function, and Regeneration @UMassChan @UMass_Medicine @CircRes https://t.co/bIbqFnaUZY Outstanding reviews from @NU_Lymphatics @CaronLabUNC @PetrovaLab @ulvmar_maria @EShelton24 @annetkiraboc1 & Valentina Kon!

[Trivedi Lab @trivedilab]

@Sathish34272774 @vascularbiology @JCI_insight @UMassChan @umassmemorial @UMass_Medicine @UMassCardio Thanks, Sathish!

[Trivedi Lab @trivedilab]

Very excited to share our recent work published as the cover story @JCI_insight https://t.co/BBT1mLUmsJ Fantastic collaboration @UMassChan @umassmemorial @UMass_Medicine @UMassCardio @vascularbiology

[JCI insight @JCI_insight]

#Cover: Pathological activation of MAPK causes lymphangiectasia treatable with ravoxertinib: https://t.co/f8YKtUGTTn
Image: H&E-stained pathological human tissue section that shows lymphangiectasia.
@trivedilab @UMass_Medicine
#Development #VascularBiology

[Trivedi Lab @trivedilab]

Checkout a new comprehensive review series on vascular and lymphatic malformations @CircRes @AHA_Research @vascularbiology @EVB_Org @endothelialnews https://t.co/qKUFW8zRDE

[Trivedi Lab @trivedilab]

Our recent manuscript showing YAP1 drives epithelioid hemangioendothelioma is published as the Cover story of July 2021 issue of @atvbahajournals @UMassMedical Wonderful collaboration with @UMassMedMCCB @umassmemorial https://t.co/yIWF3M21oo

[Trivedi Lab @trivedilab]

Our recent study by Roy Jung et al @trivedilab @UMassMedical @GSBS_UMassMed @UMass_Medicine show "Sustained Activation of #Endothelial #YAP1 Causes #Epithelioid_Hemangioendothelioma" @atvbahajournals Wonderful collaborators @umassmemorial @UMassMedMCCB
https://t.co/YVatmhc7s3

[Trivedi Lab @trivedilab]

@KathrynMooreLab @theNASciences Many Congratulations!!!

[Trivedi Lab @trivedilab]

@FitzgeraldKate @theNASciences @UMassMedical @UMass_Medicine Many many congratulations!!! Wonderful news!

[Trivedi Lab @trivedilab]

@EbruErbayLab @KathrynMooreLab Congratulations!!!

[Trivedi Lab @trivedilab]

@RogerJDavis1 @ProgMolMed @UMassMedical @GSBS_UMassMed Congratulations!!!

[Trivedi Lab @trivedilab]

Recent work from our lab @trivedilab @UMassMedical @UMassMedCancer @GSBS_UMassMed is published as Cover in July issue of @JExpMed Fantastic collaboration with @umassmemorial

[Journal of Experimental Medicine @JExpMed]

On our July cover, Janardhan et al. demonstrate endothelial KRAS or BRAF gain-of-function mutations as a causal mechanism for hepatic vascular cavernomas. Image © Janardhan et al., 2020. Read the article: https://t.co/oFUYWcmBKr
Read the JEM July issue: https://t.co/vnFC94E0uZ

[Trivedi Lab @trivedilab]

@DrKoupenova @JaneFreedmanMD Fantastic! Congratulations Milka!

[Trivedi Lab @trivedilab]

Harish Janardhan in our lab @trivedilab @UMassMedical show #KRAS or #BRAF mutations cause #hepatic #vascular cavernomas treatable with MAP2K-MAPK1 inhibition @JExpMed #vascularbiology #hemangioma #endothelialcells https://t.co/nsrbMFy6M2

[Journal of Experimental Medicine @JExpMed]

This study by Harish Palleti Janardhan, @trivedilab, et al. @UMassMedical @GSBS_UMassMed @vascularbiology demonstrates endothelial KRAS or BRAF gain-of-function mutations as a causal mechanism for hepatic vascular cavernomas https://t.co/oFUYWcmBKr

[Trivedi Lab @trivedilab]

A recent study from our lab @UMassMedical @GSBS_UMassMed shows Hdac1/2 silence cryptic transcription to promote mitochondrial function and energy production in heart @ScienceAdvances Awesome collaboration with @chaynes329
https://t.co/FlbVfzLwfo