Another hard-won project from the lab. We've been trying to understand how proteins get into the mitochondrial outer membrane for almost a decade, and hopefully we're finally getting closer. The structure, evolution, and mechanism of MTCH2: https://t.co/gwFV9ya11V
Excited to share that I'm starting a new research group at @uclachem and @cnsiatucla!
We'll focus on the molecular architecture of tight junctions - barriers crucial for human health - using biochemical reconstitution, cryo-EM, X-ray crystallography, and cell-based assays.
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
https://t.co/DoXSB7SINt
Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2).
https://t.co/UGB8yhKnBW
Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2).
https://t.co/UGB8yhKnBW
Position Open: Postdoctoral Researcher, @pleinerlab, @Stanford, Stanford, CA https://t.co/XtAHEsrvA4
Find out more about this position as well as others in cell biology on ASCB's Job Board.
https://t.co/pAO0VoJ2cZ congrats to @annakarenorta@naditasofia and the rest of the @clemonslab who made this story possible. This is a long time coming.
We are absolutely thrilled to finally share our new structure from @clemonslab of escape mechanism of the smallest phages (φX174) by breaching the peptidoglycan layer, now out in Science! https://t.co/haFGabV5eE
🧵 In this thread, I'll give you a sneak peek of the YES complex👇🏼
@markabelan Nice graphic! Few minor inaccuracies: (1) eukaryotes evolved from archaea not cyanobacteria, (2) choanoflagellates are not a direct ancestor but rather a sister group to animals, unikont, opisthokont, or amorphae would be fit better in that spot.
Our lab is looking for postdocs! 🌴🌞
We value scientific and cultural diversity and collaborative science.
If you think you could excited about membranes, mitochondria, or microscopes🔬, please get in touch!
@HHMINEWS @Caltech@BMBCaltech
Our latest work from @theJensenLab on cryo-ET of Legionella Dot/Icm T4SS is now available on @biorxiv.
https://t.co/xYYlbrBVys
Here are some key findings:
1/7
Check out our nanobody-based protein purification protocol. We’ve had great results using this for a variety of applications including cryo-EM sample prep, IDing interaction partner via mass-spec, and functional/biochemical experiments. Very clean and high yield!
Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec characterization can be a pain! Our new protocol preprint https://t.co/J5tBObCUwR describes how anti-GFP & ALFA tag nanobodies can make your life easier (1/6)
Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec characterization can be a pain! Our new protocol preprint https://t.co/J5tBObCUwR describes how anti-GFP & ALFA tag nanobodies can make your life easier (1/6)