Tjakko van Ham

Associate prof, clin lab specialist, functional genomics & RNA diagnostics of genetic disease, zebrafish, glia, leukodystrophy

[Wittamer Lab @ValerieWittamer]

🚨Please RT🚨 We are hiring! We have two immediate #postdoc openings! If you are interested in studying #microglia #development and functions, and want to use a cool animal model, #Zebrafish, to do that, please apply! More info: https://t.co/95a8SMIppZ

[Tjakko van Ham @vanHam_lab]

Happy our paper on RNA-seq to diagnose rare genetic disorders is out in @AJHGNews with @GraziaMancini3 @Jordy_Dekker_ and others from @Erasmusgenetica! 🎉🎊

[AJHG @AJHGNews]

New! @Jordy_Dekker_ et al. provide a web-based tool to improve RNA-Seq-based analyses of neurodevelopmental disorders
https://t.co/vTkvqLZUad

[Stefan Barakat @StefanBarakat]

📣📢Hiring alert❗️
We are looking for a computational postdoc to join our team @Erasmusgenetica @ErasmusMC, working on the #noncoding genome & #epilepsy. Please RT!
#ZonMw #Vidi #raredisease #generegulation #neurodevelopment #enhancer #teamsport #genetics
https://t.co/ip50u9f7Gh

[Tjakko van Ham @vanHam_lab]

@DePaterLab @ckoyunlar Congrats Emma and Cansu! 👏🎉🎉

[Tjakko van Ham @vanHam_lab]

@NeuroNiko @wmberdowski @Lesliezfish Thanks Nick!

[Tjakko van Ham @vanHam_lab]

Happy to announce a new paper from the lab! Very proud of this work by senior PhD candidate @wmberdowski (1st 1st author paper) others from the lab @Lesliezfish & collaborators not on twitter:
https://t.co/WQclWVgwGW
#ErasmusMC #zebrafish #glia #leukodystrophy #RareDisease 1/9

[Tjakko van Ham @vanHam_lab]

@wmberdowski pursued this/other aspects further in the last 3 yrs, with great perseverance, and our conclusion is that it could be a compensatory astrocytic phenotype indeed.
As always this also raises new questions (e.g. do abnormal astrocytes contribute to leukodystrophy?)

[Tjakko van Ham @vanHam_lab]

We then asked the question: could we get a glimpse of what consequence is of lower microglia density?
#multiomics Proteomics and RNA-seq data led to us to an abnormal endocytic astrocyte phenotype in #zebrafish and in #ALSP associated with lower microglia density. 5/9

[Tjakko van Ham @vanHam_lab]

Having shown the loss of microglia in #ALSP, this supports the idea that stem cell transplantation could benefit ALSP patients (as shown in several small scale clinical studies) Thanks to all involved @Erasmusgenetica, and ActaNeuropath for constructive/efficient review! 9/9

[Tjakko van Ham @vanHam_lab]

I was quite excited about the original findings, and applied to some grant to follow up on this (which I didn’t get 🙄). But continued the research regardless😛!
Also see (in Dutch) https://t.co/bk3asiJ4Xb
8/9

[Tjakko van Ham @vanHam_lab]

@rogiermin @Czopka_Lab @F_deVrij Indeed, thanks for initiating Rogier, fun to organize and to hear about novel white matter cell functions & tools to study them & clinical perspective!

[Tjakko van Ham @vanHam_lab]

Nice indeed 👏and nice supporting role by #zebrafish genetic models @Jordy_Dekker_

[Stefan Barakat @StefanBarakat]

Nice talk by our colleague Daphne Smits from @GraziaMancini3 lab @Erasmusgenetica identifying CLEC16A as a New NDD gene
#ESHG2022

[Tjakko van Ham @vanHam_lab]

Awesome (virtual) chalk talk (no slides) by @OdedRechavi
Question in Q & A "I can't see the slides"
Oded: "there are no slides" 😀 #ESHG2022 #rnainheritance https://t.co/Pn0oTL44uC

[Tjakko van Ham @vanHam_lab]

Very nice/proud to see @Jordy_Dekker_ present this: rotated as 1st yr MSc in '15, came back after his MD for more and now close to get his PhD in lab cosupervised w/ @GraziaMancini3 and together w/Functional Genomics unit @Erasmusgenetica at #ESHG2022

[Tjakko van Ham @vanHam_lab]

Our new Preprint: https://t.co/hoGu8jFFGb

Finding a cause in rare genetic disorders is key for treatment/prognosis/counseling, but often this cause is hard to find in DNA. Diagnostic RNA-sequencing improves diagnosis for neurodevelopmental disorders https://t.co/sI6y4xnPz1

[Tjakko van Ham @vanHam_lab]

Presented @ #ESHG2022 by PhD student @Jordy_Dekker_ !