Dr Vinay K S

Pathologist- Institute of Nephrourology @bangalore,India
Interested in Nephropath, uropath, tx pathology! GlomCon Fellow.
Views and opinions - my own

[Tiffany Caza @Tiff_Caza]

Fun with EM. . .It's a macrophage caught in the act :-)

[Toby Schmitt, MD @TobyASchmitt]

Papillary renal neoplasm with reverse polarity:
- Papillae lined by bland cuboidal cells with nuclei oriented AWAY from the basement membrane
- GATA3+

See the whole slide and more info:
https://t.co/3rAlL7a2Yu

[Arkana Laboratories @arkanalabs]

Cortical microabscess formation is a clue to the presence of an infectious organism. Various bacteria, viruses, fungi, and even parasites may cause similar appearing lesions. This biopsy is taken from a renal transplant patient with acute kidney injury and microscopic hematuria. The low-power image shows a dense mixed cellular infiltrate involving the tubulointerstitium (Fig. 1). Higher magnification shows tubulitis with intratubular leukocytes and rare structures suspicious for fungal elements (Fig. 2). Gomori methenamine silver staining confirms the presence of budding yeast forms (Fig. 3 arrow) with hyphae and pseudohyphae. Fungal isolates from urine culture showed colony morphology characteristics consistent with Candida species.

#TeachingPoints #kidneypath #renal #pathology

[path_clicks @hannibal_l60340]

The urothelium is composed of 3 distinct cell layers:
🟢 Basal cells → CK5, CK14, p63, CD44
🟣 Intermediate cells → CK18, GATA3
🔴 Umbrella cells → CK20, Uroplakin, GATA3
📚 Save this for quick revision.
#pathology #uropathology #bladder #urothelialcarcinoma #path_clicks

[path_clicks @hannibal_l60340]

A tumor with relatively bland nuclei can still be high-grade if it exhibits Pattern 4 or 5 architecture. This is the concept that many trainees initially miss.

#path_clicks #pathology #trending #progress #Histopathology
https://t.co/aMEIRGozAc

[Renal Path Labs @RenalPathLabs]

Some off-beat and slightly rare cases among the routines..
Came in just 3 days to prove the versatility and non-monotonus nature of Kidney diseases!! Age-no bar.
#KidneyBiopsy #RareRenal #Nephpath #RenalPathLabs #AskRenal #PathTwitter #NephTwitter #RenalPathology #PoojaMaheshwari

[Dr Vinay K S @vinaypush]

@DrCycloPath Low grade oncocytic tumor!

[Dr Vinay K S @vinaypush]

@Kenny92954457 Papillary RCC, kidney?

[Dr Vinay K S @vinaypush]

@arkanalabs @set_fortess Michaelis Gutmann body!?

[Jonathan Zuckerman MD PhD @JZRenalPath]

Classic example of autosomal recessive polycystic kidney disease. Large kidneys with poor corticomedullary differentiation radially arrayed cysts. Fusiform dilatation of radially oriented cortical and medullary collecting duct. #renalpath #gupath

[Jonathan Zuckerman MD PhD @JZRenalPath]

Sometime the casts have eyelashes. Amyloidogenic variant of light chain cast nephropathy. #renalpath #nephrology #pathtwitter

[Sanjeev Sethi @SethiRenalPath]

Kidney biopsy: Great teaching case

Severe inflammation and necrosis with abscess formation.

Look carefully=you see cells with large nuclei in the mix of inflammatory cells.

IHC= Positive staining for ADENOVIRUS.

DX: Adenovirus-associated interstitial nephritis.

55-yr old with kidney &
heart transplant, fevers, rise in serum creatinine.

[@isaalvaradoc @vintage81106614]

At first glance. A 19 yo man presented with a 2.6x2cm tumor of the left testis. Pure Germ Cell Tumor. Dx. Yolk Sac Tumor. #pathresidents #pathology #pathTweeter #Testis #Tumor

[Arkana Laboratories @arkanalabs]

The EM photomicrograph shows capillary walls that are uniform and of normal thickness with no electron dense immune complex-type deposits noted within the capillary walls or mesangium. Additionally, numerous podocyte cell bodies are present and unremarkable and epithelial foot processes show no significant effacement. At the top left of the image you can even see Bowman’s capsule and unremarkable parietal epithelium. These findings are those of a normal glomerulus by electron microscopy. No pathologic changes are present in this image.

#renalpath #kidneypath #pathology #renal #pathtwitter

[Kanishk Gupta, MD @kanishk10246585]

19/M with exercise-induced rhabdomyolysis presenting as dialysis-dependent AKI.

Kidney biopsy showed acute tubular injury with reddish-brown pigment casts. Myoglobin IHC was strongly positive, confirming myoglobin cast nephropathy.

#NephPath #AKI #Rhabdomyolysis

[Kanishk Gupta, MD @kanishk10246585]

Rare renal manifestation of malaria-associated AKI.

Kidney biopsy showed collapsing glomerulopathy with severe acute tubular injury in a patient with P. vivax infection. IF negative.

An uncommon but important association.
#NephPath #RenalPath#KidneyBiopsy #Malaria #CollapsingGN

[Arkana Laboratories @arkanalabs]

What is your diagnosis?

#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath

[Dr Vinay K S @vinaypush]

@arkanalabs IgG4 related disease with storiform fibrosis!

[PSRP @AbdipourPSRP]

The kidney biopsy showing severe tubular injury, with several foci displaying nuclear cytopathic change typical of BKV infection (arrows). Inset: an SV40 stain for BKV antigen is strongly positive in the abnormal tubular nuclei, confirming the presence of BKV.

🔗Read more👉🏻 https://t.co/S9nU6kDZcP

[Dr Vinay K S @vinaypush]

@nephromythri @ISNkidneycare Congratulations 🎉