Dongdong Wang (王冬冬)

Assistant Professor in the Department of Medicine, McMaster University

[Logan Townsend @LoganTownsend86]

Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation and fibrosis in mouse models of MASH

https://t.co/QsWOWKoyXA

[Journal of Clinical Investigation @jclinicalinvest]

MASH: the nexus of metabolism, inflammation and fibrosis

This review by Gregory R. Steinberg @DrGregSteinberg & colleagues @McMasterU is part of JCI’s ongoing series, Evolving Insights into #MASLD and MASH Pathogenesis and Treatment with series editor Scott Friedman: https://t.co/04FecXeO0i

[Logan Townsend @LoganTownsend86]

check out our latest "ACLY inhibition promotes tumour immunity and suppresses liver cancer"

https://t.co/PkIrvJmjN1

@NaturePortfolio @Nature

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

GDF15 links adipose tissue lipolysis with anxiety https://t.co/9fZsp19hfj

[@MacMODR @MacMODR]

Our 1st #MODR seminar of 24/25 will feature Dr. Shingo Kajimura @harvardmed . The @KajimuraLab focuses on the molecular basis of bioenergetics in health & disease. Don't miss it on Sep 19, 2024, from 12-1 PM! In-person in HSC 1A5 or on Zoom https://t.co/8mkV6rLMlo

[Dongdong Wang (王冬冬) @wddong1988]

Happy to share the cutting-edge technology Spatial Transcriptomics established recently in @MacMODR at McMaster University recently: https://t.co/A1EtrDA5qK

[ADA Professional Publications @ADA_Pubs]

Introducing DiabetesBio! The inaugural January #DiabetesBio #Podcast is now online.

Topic: Fatty acids on a mission: Boosting GDF15 and cutting down on food intake through the GFRAL signaling axis. #NutritionScience #GDF15

🎙️https://t.co/VOgY9gBnHj

@thewilliamslab
@DarleenSandoval
@wddong1988

[Diabetes, an ADA research journal 🧪 @Diabetes_ADA]

The January 2024 issue of Diabetes is live at https://t.co/V4ATwNAQhU, featuring latest scholarly research on #diabetes.

In This Issue:
- LysoPIs are upregulated following human ß-cell loss
- Re-epithelialization of Diabetic Skin and Mucosal Wounds
- and more!

[Dongdong Wang (王冬冬) @wddong1988]

Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways https://t.co/yiQpFmyKKM

[Muscle Health @MHRC_YorkU]

Please join us Friday (3pm Toronto time) for the MHRC Seminar featuring Dr. Irena Rebalka (McMaster U) who will speak on "Muscle metabolism and the effects of exercise in type 1 diabetes". Get the link: https://t.co/XLglHb0yWu
Passcode: 936832

[Logan Townsend @LoganTownsend86]

Macrophage AMPKβ1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis and atherosclerosis in mice

@iScience_CP @CellPressNews @EmDay4 @EricMDesjardins @wddong1988 @DrGregSteinberg @Immunometabolab
https://t.co/NpCYLOH1Me

[Logan Townsend @LoganTownsend86]

Fatty Acids Increase GDF15 (from the kidney) and Reduce Food Intake (and body weight) Through a GFRAL Signaling Axis.

Equal caloric load of glucose did not suppress food intake or reduce body mass

https://t.co/b2UmdYErmK

[Eric M. Desjardins @EricMDesjardins]

Check out our team's work showing that a GLP-1R agonist and Bempedoic Acid have combinatorial benefits to reduce NASH and hepatic fibrosis in mice. @CellRepMed @DrGregSteinberg @MacMODR @EsperionInc https://t.co/2wdgcciRmQ

[Nature Metabolism @NatMetabolism]

COMMENT | Led by @DenisPBlondin (@USherbrooke):

Authors argue that skeletal muscle #thermogenesis, rather than the stimulation of thermogenic adipose tissue, is required to elicit these benefits in humans.

👉 https://t.co/5cLIhP5Q8Q

https://t.co/4SM1kZFO3J

[Logan Townsend @LoganTownsend86]

Happy to share that my paper with @DrGregSteinberg @TheEndoSociety where we discuss how AMPK coordinates the hormonal responses to cold, exercise, fasting, feeding, and obesity is the Featured Articled of the Week. Check it out!
https://t.co/nwtwOEX8np

[Nature Reviews Endocrinology @NatureRevEndo]

AOP #ResearchHighlight: GDF15 promotes weight loss by enhancing energy expenditure in muscle (£) https://t.co/WMrzm7qV38
@HollowayMitoLab @LoganTownsend86 @JohnSpeakman4 @wddong1988 @MacMODR @McMasterU @MacDeptMed

[Nature Metabolism @NatMetabolism]

#NatMetabPicks | In @Nature led by @DrGregSteinberg (@McMasterU):

GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater #weightloss and reductions in #NAFLD compared to caloric restriction alone.

https://t.co/uHfTrAxO41

[Dongdong Wang (王冬冬) @wddong1988]

GDF15 boosts muscle energy burn https://t.co/BgVPT4SXgp

[Dongdong Wang (王冬冬) @wddong1988]

@_atanas_ Thanks dear Ata!

[Matthew Watt @MattWattUnimelb]

Fab new work from ⁦@DrGregSteinberg⁩ GDF15 promotes weight loss by enhancing energy expenditure in muscle. Great job mate. #obesity #muscle https://t.co/O8LCcHNKkD