Will Patrick

Founder & Board Member Culture Biosciences

Love fabrication, design, biology, and staring off into space.

[Will Patrick @wgpatrick]

I built an eval to measure the ability of various LLMs to create CAD. Gemini 2.5 and o3 are leading the pack.

It looks like reasoning may be a big enabler. Anecdotally, I've noticed that the reasoning models effectively think through how they're going to make the part.

[Ofir Press @OfirPress]

It's crazy how great LMs are at 3D modeling, a task that was probably a very small % of their pre-training and probably 0% of their post-training.

From @wgpatrick: https://t.co/4hm4gYCE6L

[Will Patrick @wgpatrick]

New blog post.

Vibe Code Everything.

I've found it stunningly useful to use Cursor to do non-software tasks. For example, creating a book for my son and creating a financial model. Other founders I know are doing the same thing.

https://t.co/lObCyUemcU

[Will Patrick @wgpatrick]

@julianlehr But isn't telling a LLM, "Make me a nicely formatted PDF of [whatever the thing I'm working on with the LLM", a form of hyper data compression. You're effectively replacing 100s to thousands of line item actions ("Ctrl-B for Bold") with a simple command.

[Will Patrick @wgpatrick]

@SynBio1 I think that all parts of the infrastructure to develop or make industrial products produced will remain, by and large, centralized.

One can imagine a maker community that makes real products. But - it will probably remain small compared to industrial applications.

[Will Patrick @wgpatrick]

@alexlorestani In other words, the capacity apocalypse is destiny, if there are a number of successful molecules hitting the existing CMO fermentation capacity at the same time. There would be a crunch; that would be resolved once supply catches up. But it will take some time.

[Will Patrick @wgpatrick]

@alexlorestani With a successful product-market fit and good economics (and, thus, to your point, interest from CMOs) -- the challenge, I imagine, becomes the timeline to build out additional capacity for the CMO. Usually, it's 3-5 years.

[Will Patrick @wgpatrick]

@alexlorestani If (big if) alternative protein cost per kg gets to where we all want and hope it to be (<$10/kg), then you're totally right. I've done some very basic modeling that estimates the infrastructure need to be ~10BL, something like 100-200X today's global capacity.

[daryl herzmann @akrherz]

15 minute pressure altimeter change via ASOS NWS/MADIS 5 minute interval data. Shows the shockwave from the #Tongaeruption , feel free to use as you wish.

[Chris Wintersinger @Cwintersinger]

Can DNA be made to assemble into giant structures as intricate as living cells? In the preprint I led, we put ~1000 unique origami nanorods into shapes like this ghost, with a footprint larger than a single E. coli! (https://t.co/afKdSKB7JQ)

[Will Patrick @wgpatrick]

@willcanine @opentrons I hope you feel great and proud of what you built. Opentrons has made a huge impact on the lives of many scientists and non trivially democratized biotech tools. Looking forward to seeing what you don next and hope to hang soon!

[Will Patrick @wgpatrick]

@esepzai Thanks @esepzai !

[Will Patrick @wgpatrick]

We'll be using this new capital to build out larger-scale biomanufacturing infrastructure, such that our customers can run pilot and full-scale manufacturing runs.

[Culture Biosciences @culturebiosci]

We at Culture are thrilled to announce our $80M Series B financing led by @npv_vc and @Synthesis_Cap. We're so excited for what’s to come as we tackle client demand for large-scale biomanufacturing. Thanks to @Forbes and @johncumbers for sharing our story!
https://t.co/mnC3GxvEO6

[Will Patrick @wgpatrick]

@SexyLikeMeiosis Thanks @SexyLikeMeiosis — would love to catch up some time and hear about your climate work.

[Will Patrick @wgpatrick]

@AnkeshMadan Thanks @AnkeshMadan !

[Will Patrick @wgpatrick]

@stevenlurie Thanks @stevenlurie — I’ve greatly appreciated your support over the years

[Will Patrick @wgpatrick]

@lina_colucci Thanks, @lina_colucci … I hope you are well!!

[Will Patrick @wgpatrick]

@erinheejoon @culturebiosci Dawwwwww thanks!

[Will Patrick @wgpatrick]

@joshuamarch Thanks Josh … let’s hang in Bernal soon!

[Will Patrick @wgpatrick]

@soroushjp Thanks @soroushjp !

[Will Patrick @wgpatrick]

@JonahCallinBack Thanks, @JonahCallinBack !!

[Will Patrick @wgpatrick]

@jrkelly @culturebiosci Thanks, @jrkelly ! Ginkgo has always been an inspiration.