Yeonwoo Park

Ph.D. student @UChicago @JoeThorntonLab
Evolutionary biochemistry
On bicycle with two cats

[Yeonwoo Park @whatdoidohaha]

@_miloj @JoeThorntonLab Regarding predicting mutational effects, there is a lot of interest and expertise converging on the problem. Check out https://t.co/1vGKxaG3LL.

[Yeonwoo Park @whatdoidohaha]

@_miloj @JoeThorntonLab This was necessary for comparing the effects of mutations across the WT proteins and detecting specific epistasis; not adjusting for background differences will cause nonspecific epistasis.

[Yeonwoo Park @whatdoidohaha]

@_miloj @JoeThorntonLab What you want is the phenotype of all WT proteins measured at the same expression level. We unfortunately do not have that because we had to adjust the expression level for each WT so that all of them show the same activity.

[Yeonwoo Park @whatdoidohaha]

@_miloj @JoeThorntonLab Hey! Thank you for building that platform and it is good to see that my analyses are replicable, at least so far!

[Yeonwoo Park @whatdoidohaha]

@AustinHPatton Thank you very much! I'm glad you liked it.

[JoeThornton @JoeThorntonLab]

Our new paper: We measured changes in the effect of all possible mutations across 700 million years of protein evolution. Our goal was to comprehensively characterize epistasis, contingency and evolutionary predictability. Out today in @ScienceMagazine.🧵 https://t.co/TNJrIpoav7

[Marta L Wayne @MartaWayneBio]

Got a question about “Historical memory, epistasis, and contingency in long-term protein evolution”? Find Yeonwoo Park in the Grad Student Excellence Symposium Q&A room off Auditorium 1 in both the Asia/Pacific and EU/Africa hubs. @whatdoidohaha @OfficialSMBE #SMBEv2021 #SMBE2021

[Marta L Wayne @MartaWayneBio]

Get ready...get set... get excellent! The 2021 SMBE Graduate Student Excellence Award Symposium is on Sunday 4 July: 02:30 UTC (Asia) and again at 09:30 UTC (EU/Africa). @OfficialSMBE #SMBEv2021 @adeflamingh @SunMengyi @TheaFRogers @KowalczykAmanda @whatdoidohaha @mp_harwood

[Marta L Wayne @MartaWayneBio]

Got excellence? Yeonwoo Park does. Hear him talk about his work during the 2021 SMBE Graduate Student Excellence Award Symposium talks are on Sunday 4 July, starting at 02:30 UTC (Asia) and again at 09:30 UTC (EU/Africa).
@OfficialSMBE
, #SMBEv2021, #SMBE2021,
@whatdoidohaha

[Yeonwoo Park @whatdoidohaha]

@the100footpole @StefanBassler @EMBLEvents @JoeThorntonLab I'd like to know the answer to that question too. We'll be submitting our manuscript soon!

[Stefan O. Bassler @StefanBassler]

Fascinating talk by Joe Thornton @JoeThorntonLab on the memory length of (epistatic) mutations, the amount of sequence divergence over which the temporal correlation of a mutation’s effect is reduced by 50%.
Very relevant for antibiotic resistance prediction!
#EMBOPredictEvo