wHEALTH

Consistency & leverage win the race. Let’s play the long game 📈🔬by @natashawiscombe

[wHEALTH @whealth_]

@SahilBloom @NatashaWiscombe same same

[Nithya Shri @Nithya_Shrii]

Please never forget this:

The best thing you can do for your career is build a happy life outside of it.

[wHEALTH @whealth_]

@Nishan_011 Nano

[wHEALTH @whealth_]

@alex_prompter Claude

[Natasha Wiscombe @NatashaWiscombe]

For those of us that have been hacking our biology for years.. biomarkers & biometrics are old news. We want something personalized, proactive and actually preventative.

I dive into a few healthspan therapies & biotech doing just that on Substack (link in comments below):

- HBOT: systemic repair trigger (telomeres, senescence, mitochondria)

- Mitochondrial transfer: organelle replacement for heart/brain/muscle

- Peptides + circadian restoration that pre-dated reprogramming

- Partial cellular reprogramming: short, controlled bursts of Yamanaka factors that erase decades of epigenetic damage, restore youthful gene expression and rejuvenate tissues

All of these are different doors to the same destination: safely supporting multiple hallmarks of young cells into our adult tissues..

To make this actionable: really excited about what the team at NIVO is doing in cellular regeneration and epigenetic reprogramming. They’re providing insights on cellular health now and eventually, personalized treatments.

https://t.co/dN3CIJs6FY

👆🏽link to their early access portal

So, what are iPSCs and how can they help me live longer & healthier?

Well, iPSCs are reprogrammed from your own cells (e.g., skin, hair follicle, blood), creating a "cellular twin" for disease modeling and biomarker analysis. This enables hyper-personalized insights into epigenetic age, mitochondrial function, or early disease signatures - far far beyond standard bloodwork.

🔓 Think cellular reset drips: Heal from the inside out, customized to erase fatigue or autoimmunity at the source

🔓Partial reprogramming "edits" diseased epigenetics or replaces faulty cells entirely, effectively "deleting" states like senescence or mutation loads. It's not curing cancer overnight persay, but for chronic issues it's transformative.

🔓Preclinical and early clinical work includes iPSC-derived cells can be used for organ and tissue regeneration or transplant.

Questions, thoughts, concerns?

To the future of your cellular health,
N

[Alex Hormozi @AlexHormozi]

Stop whining. Every position has an advantage.

Younger = cutting edge
Older = more experience
Smaller company = more personalized
Bigger company = longer track record
Rich = resources to use
Broke = nothing to lose

You arent limited by your resources, only your resourcefulness

[Nithya Shri @Nithya_Shrii]

Stay humble and play dumb. People reveal who they truly are when they think they are smarter than you.

[wHEALTH @whealth_]

This has nothing to do with the payment system and everything to do with the crap we are putting into our bodies and/are exposed to in the environment.

We have the best doctors in the world but they can't work magic on if 88% of Americans are metabolically unhealthy.

[Bernie Sanders @BernieSanders]

Life expectancy:

🇨🇭84.2
🇯🇵84.1
🇸🇪83.4
🇦🇺83.1
🇫🇷83.1
🇧🇪82.5
🇳🇱82
🇨🇦81.7
🇦🇹81.6
🇬🇧81.1
🇩🇪80.6
🇺🇸78.4

There is no reason why the richest country in the history of the world should have a lower life expectancy than every other major country on earth. Medicare for All now.

[M Mohan @mukund]

A guy just used @AnthropicAI Claude to turn a $195,000 hospital bill into $33,000.

Not with a lawyer. Not with a hospital admin insider.
With a $20/month Claude Plus subscription.

He uploaded the itemized bill. Claude spotted duplicate procedure codes, illegal “double billing,” and charges that Medicare rules explicitly forbid. Then it helped him write a letter citing every violation.

The hospital dropped their demand by 83%.

This isn’t just a feel-good story. It’s a preview of what AI will really do next: flatten systems built on opacity.

Hospitals, insurance companies, legal firms—all rely on asymmetry. They win because you don’t have access to the same data, code books, or language.

Claude gave one person the same leverage as a compliance department. That’s a revolution.

We thought AI would replace jobs. Turns out, it’s replacing excuses.

[Jeson Lee @thejesonlee]

the hardest part about being a male founder..

in my experience is finding a girlfriend / partner that understands the short term gains that we are forgoing and the long-term optimization game that we are playing.

most women expect to have most dates paid for, their vacations covered and their partner to have the time and emotional bandwidth to support them. somebody they see as a reliable provider. this is completely understandable.

but as founders, every dollar saved is additional runway for the company. we budget down to the cent because our life’s work depends on it. every 100-hour work week slightly increases the odds of success. at this stage of life, we’re both cash-poor and time-poor — betting everything on the hope that one day, it all works out. that one day, we’ll be sitting on generational wealth — the kind most men only dream about.

even for women who understand that they might be investing in their man long-term , it’s hard not to compare. their friends are dating guys with high-paying tech jobs, who work from 10 to 3 and can afford to give them a luxury experience now, not later. optimizing for the short term is human nature — it’s hard to fight against.

to all the girlfriends out there dating early-stage founders — you’re the real ones.

and to all my fellow founders: may you find your person while you still have nothing. Because that’s the only time you’ll know she’s with you for who you are, not what you have.

[wHEALTH @whealth_]

Compound leverage >

[wHEALTH @whealth_]

@tomcrawshaw01 Skill

[Natasha Wiscombe @NatashaWiscombe]

She lived to 117.

Her cells aged - but her systems didn’t.
María Branyas, the world’s oldest woman, became a living paradox in a new Cell Reports Medicine study by Eloy Santos Pujol et al.

Despite showing classic signs of aging - shortened telomeres, immune shifts - her biology told a different story: a gut microbiome like a 40-year-old’s, an immune system in perfect balance, and an epigenome decades younger than her chronological age.

Multi-omics analysis (genomics, proteomics, microbiomics) revealed what medicine has long missed: longevity isn’t about stopping aging - it’s about synchronizing systems that age at different rates.

The future of biotech is already making moves here - companies are decoding these biological signatures to develop therapeutics that extend healthspan, not just lifespan.

From senolytics to microbiome modulation, the goal isn’t to just live longer & "not die" - it's to adventure & experience life to the fullest.

Healthspan medicine & therapeutics are going to get us there.

[wHEALTH @whealth_]

@reachvaldo Join

[Navalism @NavalismHQ]

"The most important skill for getting rich is becoming a perpetual learner. You have to know how to learn anything you want to learn."

@naval

[wHEALTH @whealth_]

@JulianGoldieSEO Yes

[Julian Goldie SEO @JulianGoldieSEO]

THIS IS INSANE…🔥

Someone just leaked 1,200+ plug-and-play N8N workflows and it’s breaking the internet 👀

They scraped everything from the official docs, GitHub, AND hidden forums 😮‍💨

⚡ AI-powered lead gen
⚡ Auto content repurposing
⚡ Sales & CRM automation

This vault would cost a lot to build from scratch.

LIKE + RETWEET + COMMENT “YES” & I’ll send you the FULL workflow + setup FREE!

[Alex Hormozi @AlexHormozi]

The person you want to become doesn’t entertain the opportunities you’re getting distracted by.

[Navalism @NavalismHQ]

"Work as hard as you can. Even though who you work with and what you work on are more important than how hard you work."

@naval

[Alex Hormozi @AlexHormozi]

You can beat 99% of people if you can master the shame of rejection, the boredom of repetition, and pain of feedback.