Xabier Vergara

PhD student in the Netherlands Cancer Institute

[Xabier Vergara @xvergara2]

Have you ever wondered if your favourite DNA repair protein modulates pathway balance depending on the local chromatin context? Check out our latest pre-print from the @MedemaRene and @bvansteensellab. A 🧵:
https://t.co/Qtfm93zgmj

[Mathias Eder @MathiasEder91]

Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out our latest pre-print from the @bvanssteensellab. https://t.co/uSkdNRbTIK

[Bas van Steensel lab @bvansteensellab]

... and we used our platform of 19 chromatin-integrated pathway reporters to probe context-dependent effects of epigenetic drugs on Cas9 editing: https://t.co/ra0DT02TFT

[Bas van Steensel lab @bvansteensellab]

We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-dependent manner. With impact on cancer genomes. Paper is finally out: https://t.co/rRZOqZdFG0

[Max Trauernicht @MaxTrauernicht]

I wrote a blog post about my PhD project at the @bvansteensellab. Give it a read! https://t.co/n5M6YjZBen

[Max Trauernicht @MaxTrauernicht]

I am happy to share some exciting work that @rschep & I started back in 2018 at the @bvansteensellab. Check out our new pre-print to learn how drugs modulate #CRISPR editing and how their effect depends on the chromatin context of the cut site: https://t.co/4Wrokq4y91. A 🧵:

[deWitLab @deWitLab]

We’re excited to share our recent #gastruloid work using sciATACseq to investigate cell-type specific regulation. This work was spearheaded by @LucaBraccioli and @TeunvandenBrand. https://t.co/o26lCJ8jOb

[Xabier Vergara @xvergara2]

@AgnelSfeir @bvansteensellab Thank you! It means a lot 🙏

[Xabier Vergara @xvergara2]

@RathSandip @MedemaRene @bvansteensellab I hope our data can useful for your research! If you need help with our data drop me a line.

[Xabier Vergara @xvergara2]

Have you ever wondered if your favourite DNA repair protein modulates pathway balance depending on the local chromatin context? Check out our latest pre-print from the @MedemaRene and @bvansteensellab. A 🧵:
https://t.co/Qtfm93zgmj

[Xabier Vergara @xvergara2]

Does your favourite DNA repair protein have CCDs? Check the heatmap yourself! And do not hesitate to contact us with any doubt or comment. 7/7

[Xabier Vergara @xvergara2]

With the help of @MathijsSanders, we validated the BRCA2 CCD in tumors. Our screen, predicted that BRCA2 represses MMEJ (favor NHEJ) mainly in euchromatin. We found that MMEJ deletions increase mainly in euchromatin in BRCA2 mutant tumors. 6/7