Rath

it’s never too late to change

[Ah-Ram Kim @ahramkim1128]

Now ESMFold2 and Protenix-v2 can be analyzed in https://t.co/CDjJhAI1dT

The example is p53-MDM2.

[Peter Ly @PeterLyLab]

The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏

Full posting: https://t.co/INoSPaqx95

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Rath @RathSandip]

@luijsterburglab This is indeed a cool finding. Going to read it today. But just curious are these marks deposited at the same site where damage is being repaired or there is a global redistribution at damage prone loci’s.

[Rath @RathSandip]

@MolecularCell So it matters when we do the experiment

[Rath @RathSandip]

I guess bad microscopy counts too🤣

[Rath @RathSandip]

Do cells exchange the damage information to maintain epigenetic changes ??

[Nature Biotechnology @NatureBiotech]

CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci https://t.co/5VtEnCmKEB

[Rath @RathSandip]

I hope I never did a PhD…

[Oded Rechavi @OdedRechavi]

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!

[Rath @RathSandip]

JCI - Genomic adjusted radiation dose stratifies radiotherapy dosing based on tumor-specific sensitivity in HPV+ oropharyngeal cancer https://t.co/0ByrrNBg94

[Rath @RathSandip]

@MolecularCell Are those RNA have any specific PTM or have methylation or hydroxethylatiom signatures. Whether lipid modifications on those RNA would help it to tether to Ku more effectively..

[Rath @RathSandip]

@ShorterLab It would be interesting to understand in future how it plays a role in R loops stabilization

[Rath @RathSandip]

@MolecularCell RIF1, BARD1 and SAMHD1 are the next big targets

[Rath @RathSandip]

@Yael_David__ @MolecularCell @IfeAkano cool finding

[Rath @RathSandip]

@DNAmyStrom Beautiful piece of work

[SheqLab @ShechnerLab]

Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

https://t.co/gVMCVbSRoS

[Rath @RathSandip]

@FitFusion__ I am glad I didn’t

[Rath @RathSandip]

The universe works in mysterious ways. Thank you for everything

[andre nussenzweig lab @nussenza]

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: https://t.co/1AvK5l8CD0. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!