Yale Department of Genetics

Official Twitter home of the Yale University Department of Genetics. Sharing the latest advances in genetics, news and upcoming events.

[Journal of Clinical Investigation @jclinicalinvest]

Behind the scenes with the Lim lab:
Pic 1: Alison Chase and Changwoo (Chris) Lee examining a slide.
Pic 2: Changwoo (Chris) Lee, Ben Sanders, Alison Chase, and Janghoo Lim discussing science.
Pic 3: Alison Chase, Changwoo Lee, and Janghoo Lim working on transcriptomics and immunohistology.

[Journal of Clinical Investigation @jclinicalinvest]

From earlier this week: Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease driven by polyglutamine expansion in ataxin-1.

https://t.co/TAHYEx8QIU
Here, Changwoo (Chris) Lee @chchrislee, Janghoo Lim @Janghoolim @LimLabYale & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models of this incurable disease.

The image: Purkinje cell torpedoes and myelin debris in the granular layer are increased in OL-SCA1-934 cKI mice.
@LeonTejwani
#SCA1 #Ataxin1

[valentina greco @valentatormenta]

https://t.co/ytiJbMRqcr

[Krishnaswamy Lab @KrishnaswamyLab]

I will be speaking at the Spatial Biology Revolution 2026 Online Symposium on May 28th at 12:20pm EDT, alongside a host of other researchers including Bernd Bodenmiller and @jsb_ucla! You can register at https://t.co/KVGgGy5lgS

[Yale Department of Genetics @YaleGenetics]

A decade post-PhD and not sure where your research is headed? 🤔 🔬

A new Nature Careers piece offers practical advice on how to reset your research direction strategically and make the most of every opportunity.

https://t.co/D8AbPxZXDt

[Yale Department of Genetics @YaleGenetics]

'Zombie cells' are back! 🧟

Researchers have developed a technique that inserts the genome of one bacterial species into the emptied cells of another, potentially opening new doors in synthetic biology

https://t.co/IaM1MQnaVW

[Yale Department of Genetics @YaleGenetics]

Rare disease diagnoses can rely on exome sequencing, but answers may be hiding in noncoding regions. 🧬 PromoterAI is a new deep learning tool that identifies pathogenic promoter variants, which may account for up to 6% of rare disease genetic burden 🔍
https://t.co/1GoPVcAwNW

[Yale Department of Genetics @YaleGenetics]

CONGRATS🎉to Dr. Xiaona Lu on being honored with 2 prestigious awards 🏆 at the @ASGCTherapy annual meeting! Her innovative research @YaleMed is advancing gene therapy 🧬 for neurodevelopmental disorders🧠! More👇
https://t.co/yiwhBPPDsP

[Yale Department of Genetics @YaleGenetics]

A single base correction in the postnatal brain can restore protein function and reverse behavioral abnormalities. 🧬 In vivo base editing of a CHD3 variant ameliorated key features of Snijders Blok–Campeau syndrome in mice.

Read more here 👇
https://t.co/i38VYrkEjl

[Yale Department of Genetics @YaleGenetics]

It's not how much fat you eat, it's what kind 🥑

@YaleMed Prof. Mandar Muzumdar @MuzumdarLab shows how monounsaturated fats protect pancreatic cancer cells from ferroptosis, while polyunsaturated fats increase their vulnerability.
See more here👇https://t.co/iXOLQTjKJg

[Yale Department of Genetics @YaleGenetics]

The key to understanding autism may not be the genes themselves, but how they disrupt the brain. 🧠 Research co-led by @YaleMed profs Kristen Brennand and Ellen Hoffman reveals autism genes converge on shared neural pathways. Find the full study here 👇
https://t.co/VYLDPPI1BJ

[Yale Department of Genetics @YaleGenetics]

Today at the 2026 ASGCT @ASGCTherapy Annual Meeting, our very own Xiaona Lu is receiving an Excellence in Research Award! 🎉

Xiaona is being recognized on stage during the George Stamatoyannopoulos Memorial Lecture. Congratulations — so well deserved! 🌟

[Yale Department of Genetics @YaleGenetics]

What drives cell fate decisions during human cortical neurogenesis?

🧠 A new single-cell CRISPRi screen of 44 transcription factors identifies novel regulators including ZNF219, NR2E1, and ARX, with convergent roles in neurodevelopmental disorders 👇
https://t.co/7l6v5lubYF

[Yale Department of Genetics @YaleGenetics]

Why do the same genetic variants have different effects in different people? A new atlas of gene-environment interactions across nearly 1 million individuals reveals how the environment shapes genetic associations and what that means for precision medicine
https://t.co/zGtNc9u1f0

[Yale Department of Genetics @YaleGenetics]

TODAY! 05/12/26 Genetics Seminar Series/Genetics Clinical Grand Rounds at 10:15am, Dr. Clair Francomano, MD, presents: " Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Connecting the Dots Disease."
Link below https://t.co/cuFHwi9cpD

[Yale Department of Genetics @YaleGenetics]

SAVE THE DATE! 05/12/26 for our Genetics Seminar Series/Genetics Clinical Grand Rounds at 10:15am, Dr. Clair Francomano, MD, presenting: " Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Connecting the Dots Disease."
Link below
https://t.co/cuFHwi9cpD

[Muzumdar Lab @MuzumdarLab]

🎉 Excited to share our new paper led by @Xiangyu_GigiG in @CR_AACR! 🧬 We flip the script on the RAS/PI3K relationship: PI3K is more than a RAS effector, it is also its regulator! @YaleCancer @CancerYale @YaleMedicine @YaleGenetics @yalepathology
https://t.co/4i1MzYhHWh

[Yale Department of Genetics @YaleGenetics]

SAVE THE DATE! 05/05/26 for our Genetics Clinical Grand Rounds at 10:15am, Dr. Vahid Bahrambeigi, PhD presenting: " An Overview of Pelizaeus-Merzbacher disease (PMD) and Associated Neurological Disorders."
Link below...
https://t.co/u6nqtkZkjM

[Muzumdar Lab @MuzumdarLab]

🔔New paper alert! Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in @CD_AACR shows that fat composition — not just fat quantity — governs cancer development . https://t.co/LmKSIpfKWq

[Yale Department of Genetics @YaleGenetics]

Researchers have characterized SNIPE, a novel anti-phage defence system in E. coli. 🦠 Localizing to the cell membrane, SNIPE cleaves incoming phage DNA during injection, revealing a mechanism of self vs. non-self discrimination.
https://t.co/wOjUlcUbeZ