Yongfeng Liu

[Yongfeng Liu @yfengliu]

https://t.co/QF6lSgyoaD

[EvE Bio @EvEBiotech]

EvE Data Release 2 now live!

1.4K drugs' activities at 21 7TMs including
ADRA2A
ADRA2B
ADRA2C
ADRB1
ADRB2
DRD1
DRD2
GAL1
GAL2
GHSR
HRH1
HRH3
HRH4
HTR1A
HTR1B
HTR1D
HTR1F
HTR2A
HTR5
HTR6
PTH1R
in ag & antag modes.
https://t.co/jGJ651kSTV

[Sreeparna Majumdar ( শ্রীপর্ণা মজুমদার) @sree69177681]

FASEB SRC (June 4-8, 2023)

[Sreeparna Majumdar ( শ্রীপর্ণা মজুমদার) @sree69177681]

FASEB Science Research Conference (4-8 June, 2023)

[Yongfeng Liu @yfengliu]

@AashishManglik @FASEBorg @LleBillesb Exactly. That’s a fantastic talk on olfactory receptor.

[Yongfeng Liu @yfengliu]

Bryan as the session chair at the @FASEBorg conference.

[Yongfeng Liu @yfengliu]

Chapel Hill-Carrboro City Schools Visions: Art Show

[Seva Katritch @sevakat1]

Congratulations Sush and the whole amazing team on this groundbreaking study! Highly conserved sodium site in GPCRs was proposed for ligand design since its discovery in 2012, and now this concept led to the design of safer opioids!

[Tao @TaoChelab]

It’s a long journey but finally made by this great team.

[BryanRoth @zenbrainest]

And here it is: how and why DREADD-based chemogenetics works. @hustzsc solved structures with cryo-EM analysis by @Cannabatopia and MD simulations by @rgumpper
Amazing work--have waited since 2005 to understand why DREADDs work as well as they do!

https://t.co/DnXx2ysQUI

[BryanRoth @zenbrainest]

Yuuge!
https://t.co/u9psrcUHhE

[Hideaki E. Kato @emeKato]

new release2

8DWC: CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
8DWG: CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382
8DWH: CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16

Roth lab.

[Yongfeng Liu @yfengliu]

@gori7873 Thanks, Hye Jin.

[Nature Chemical Biology @nchembio]

A new paper from @zenbrainest, @Cannabatopia and @BShoichet reports cryo-EM structures of human MRGPRX1-Gq protein complexes, providing insight into the receptor's activation and allosteric modulation mechanisms. Free to read: https://t.co/UGAT1IplXw https://t.co/cknGjfa933

[BryanRoth @zenbrainest]

Whoo hooo!!

Congrats to Yongfeng, Can, Jonathan and others--major structural insights into a novel GPCR!

https://t.co/HILQfGGHzP

[eLife - the journal @eLife]

New technology measures the release of dopamine simultaneously from hundreds of release sites at the spatial resolution of a synapse. https://t.co/3ZEccErxCi

[Can Cao @CanCao_Natural]

Finally, this is out! Thanks so much for Bryan's support and the whole team! @zenbrainest @BShoichet @gori7873 @Cannabatopia

[UNC School of Medicine @UNC_SOM]

Nobel Laureate Aziz Sancar, @UNC scientists discover anticancer properties of common lab molecule: https://t.co/rLMzfjjbnp
Cells recognize molecule EdU as DNA damage, triggering repeat, deadly DNA repair @PNASNews @AzizGwenSancar @UNCResearch @ScienceMagazine @UNC_Lineberger

[FocalPlane @focalplane_jcs]

Happy #FluorescenceFriday! Today we selected this movie from @huiskenlab published in @Dev_journal a few years ago. This is a time-lapse imaging of vasculature development in zebrafish combining light-sheet microscopy and optical tomography.

https://t.co/dz2sgJffwp