Yifu Han

Neurodegenerative diseases | Synaptic plasticity | Ichida lab

[Dion Dickman @dion_synapse]

Really excited to have this study out in @ScienceAdvances , on my birthday no less (and 'tines day!). Here we resolve input-specific mechanisms of homeostatic plasticity! Congrats @ChunJChien Kaikai and team! https://t.co/ZSJwNRwmpI

[Bruce Herring @beherring]

Latest from the lab now out in @NatureComms. Here we find that schizophrenia-associated mutations in SAP97 dramatically alter glutamatergic neurotransmission in the dentate gyrus. Big congrats to Yuni Kay and the rest of the team. https://t.co/08bMrnRhJX

[Dion Dickman @dion_synapse]

Really excited to have this study out in @ScienceAdvances ! Here we show how synapses elegantly tune inhibition of release to increased vesicle size and glutamate - through a Glutamate-Gated Chloride channel (ivermectin target)!👇https://t.co/ru6BqU5Guj

[Chengjie “Benji” Qiu 邱承杰 @ChengjieQ]

Curious about which antibodies work best for our best friend GFP in immunostaining? We want to know the answer too! So we quickly tested 12 anti-GFP antibodies we have in the lab and found our new favorites! Scroll down for how we tested them! 😉

[Yifu Han @YifuHan]

@MichaelBReiser @dion_synapse @flyknows @JoshmanRaji @gsxej Thanks for your suggestion!! We used nuclear reporter with 4 NT drivers, and found a majority of Ach in optic lobs. But still 10% unidentified cells compared to the total # of Elav staining. Maybe they're not included or inaccuracy for densely compacted cell bodies in optic lobs.

[Yifu Han @YifuHan]

@pragya1211 Thanks P!! Our Rig3 is multi function now!!

[Yifu Han @YifuHan]

With our widefield system, we can now see distinct spontanesous quantal events from tonic (Ib) and phasic (Is) syanpses simultaneously at Drosophila NMJs, which is homogeneous with ephys recording. Is quantal size is 70% larger than Ib by postsynaptic Ca signal.

[Yifu Han @YifuHan]

@wang_yupu Thanks!! To calculate QC, we need to acquire the entire muscle4 NMJ. Then the deltaF will be even smaller. For registration, I used the alignment tool in Nikon Element or a ImageJ plugin named "Image Stablizer". Both gave me good correction of movement.

[Yifu Han @YifuHan]

@nytimes Alright NYT. I admit that in my home town, everyone eats pangolin, bats and whatever you could imagine. Oh and you know what? They even produce vaccines from CHO cells!!!

[Yifu Han @YifuHan]

Say goodbye to the crazy 2020!! 🎉🎆 Just reminded me of my first new year's Eve in Wuhan at this famous clonial-era landmark 8 year's ago.

[Jinho Kim @jkimkj]

Ever wondered what happens in our brain when we touch a 3D object? How about when we recognize an object just by touching it? We looked into mice brain to get some idea. https://t.co/yUFe55KLA3… (Feat. @JonCheung6 and @incisrdrew Prod. by @AndrewHires). A lay-word thread (1/12)

[Dion Dickman @dion_synapse]

Great to have this pape out @PNASNews (2 years after Beril graduated)! We identified an auxiliary glutamate receptor subunit first found in worms, Sol-1, to be needed for presynaptic adaptive plasticity. Big thanks to everyone for their efforts, especially @pragya1211 !

[Dion Dickman @dion_synapse]

Interested in target-specific homeostatic control of synaptic function? Short paper out where we re-visit a manipulation that reveals really interesting target-specificity of synaptic plasticity...congrats @pragya1211 and the rest of the team!

https://t.co/YMYTELTiF3

[Yifu Han @YifuHan]

This is extremely helpful and something every research institute should have done for their employees.

[Dr. Carmen Falcone @CarmenFalcone6]

***What I learnt today about the proclamation***

The UC Union of Postdocs and Academic Researchers explained us more details about this recent executive proclamation (valid until Dec 2020).

I’ll try to summarize it in thread. (1/n) 👇👇👇

[Yifu Han @YifuHan]

GOAT!! 💪

[South China Morning Post @SCMPNews]

He has just one arm, but that doesn't stop this Chinese teenager from excelling in basketball – and impressing @NBA star @StephenCurry30.

[Yifu Han @YifuHan]

@maxwellmbay Not surprising. Based on a Pew poll, this tension is not a GOP thing. Biden also need to show some toughness unless he wants to lose votes. Kind of a patriotism show before the election. There might be some drawbacks and more practical solutions for tension after Nov?

[Development @Dev_journal]

Arrested (larval) development: a new window to synaptic plasticity
A Research Highlight featuring Sarah Perry @pragya1211 @dion_synapse & colleagues' new paper
https://t.co/iUvXBwkk12

[Dion Dickman @dion_synapse]

Interested in how synapses adapt to a novel life state to which they never evolved? See what happens when fly larvae are developmentally arrested and persist for over 35 days (rather than the conventional 5)!

https://t.co/I7nAjIonAF