#OncTwitter#regulatory#bcsm
📣 #FDA has approved trastuzumab deruxtecan + pertuzumab for 1st-line tx of adults w/ HER2+ unresectable or #MetastaticBreastCancer based on DB-09 trial:
🏆44% ⬇️ in risk of progression/death vs THP (mPFS: 40.7 vs 26.9 mos).
⚠️ ILD ~12%
In this FULL episode of CHM Conversations, two of breast oncology’s brightest specialists — @JAMouabbi and Dr. @PTarantinoMD — explore how trastuzumab deruxtecan (T-DXd) has fundamentally restructured therapeutic strategies across HER2-positive and HER2-low disease, while “curing” what was once thought to be really aggressive disease.
🔬 Topics include:
• The T-DXd era: from preclinical promise to clinical breakthrough
• Reframing HER2 biology: Low and ultra-low as therapeutic targets, not distinct entities
• Management of brain metastases
• Strategic dominance in metastatic disease: DESTINY-Breast03, 04, 06, and 12 insights
• Sequencing treatment strategies and minimizing ILD risk
• Minimizing ILD risk: The Five S's — Screen, Scan, Synergy, Suspend, Steroids
• The future of early-stage disease: Neoadjuvant and adjuvant trials challenging classical chemotherapy models
🎧 Don’t forget to like, share, and subscribe for more CHM Conversations.
#BreastCancer #OncologyPodcast #TDXd #HER2Low #CHMConversations #PrecisionMedicine #CancerResearch
Breezy Bowl XX 🤝🏿 @BroccoliCity
Chris Brown, Bryson Tiller and Summer Walker will perform at Nationals Park in Washington, D.C. to conclude Broccoli City Weekend.
🗓️ August 8-10, 2025
📍Nationals Park (Washington, D.C.)
📀 Chris Brown, Summer Walker & Bryson Tiller
What a way to ring in the New Year! 🎉 Huge thanks to everyone who came out to celebrate with us and made the night unforgettable. Special shoutout to #mariahthescientist for blessing the stage and bringing the vibes. ✨ Here’s a recap of an epic NYE! 🥂💃 @A1events