An 86-year-old man presented to the neurology clinic with 2 years of progressive memory loss and difficulty walking. An MRI showed microbleeds that appeared as hypointense foci throughout the lobar regions.
Read the full case details in the Images in Clinical Medicine article “Cerebral Amyloid Angiopathy”: https://t.co/Q3Otm9lH9q
Learn more about cerebral amyloid angiopathy in a new Review Article: https://t.co/dEMf0G2Nky
👩🎨Woman in her 50s referred after an incidental finding on a routine brain screening study. Neurological examination was completely normal, and no cranial nerve deficits were identified.
🤔What would be your differential?
Shrimp sign.
A recently described MRI marker used to identify cerebellar progressive multifocal leukoencephalopathy (PML).
It is characterized by a well-defined white matter lesion that abuts and outlines the dentate nucleus without invading it.
https://t.co/s4Rl9g8Ljw
Super duper rare but a classic!
Erdheim-Chester Disease!
Non-Langerhans histiocytosis with a constellation of findings you won’t forget once you’ve seen them:
🦴 Symmetric sclerosis of long bone diaphyses/metadiaphyses (sparing epiphyses)
🫘 Bilateral renal soft tissue infiltration → “hairy kidneys” on CT
🫀 Soft tissue encasement of the aorta → “coated aorta” sign
🧠 CNS involvement — pituitary stalk thickening, cerebellar/brainstem lesions
🔶 Orbital infiltration causing proptosis
⚡ Key associations:
→ BRAF V600E mutation in ~50%
→ Diabetes insipidus is a common presenting symptom
→ 18F-FDG PET/CT is invaluable for staging & treatment response
📸 When you see bilateral perirenal soft tissue + long bone sclerosis on a CT — think ECD!