ZagasYum

Miltoniano

[ZagasYum @zagasyum18]

"En el ser humano hay más cosas dignas de admiración que de desprecio"

Algo que se aprende en todas las pestes, tal y como nos enseñó Albert Camus

[ZagasYum @zagasyum18]

@reumacia @rosataberner Entonces, por esa rwgla de tres, vender vino sería también punible porque hay alcohólicos

Somos adultos
Que cada cual decida qué hacer con su vida

[Phil Hoyeck @PAHoyeck]

My 10 favourite films

1. 2001: A Space Odyssey (1968)
2. The Godfather (1972)
3. Lawrence of Arabia (1962)
4. The Sound of Music (1965)
5. Gladiator (2000)
6. The Third Man (1949)
7. Apocalypse Now (1979)
8. Forrest Gump (1994)
9. Goodfellas (1990)
10. Solaris (1972)

[NEJM @NEJM]

A 42-year-old man on prolonged immunosuppressive therapy for chronic graft-versus-host disease after stem-cell transplantation for acute lymphoblastic leukemia presented to clinic with a 2-week history of urinary frequency and weak stream. Read the full case details and submit your answer or see how others responded: https://t.co/vk73MHzLLH

[Gabriel Puche, MD/PhD @gabi_puchepalao]

🦟📚 ¿Te lías con los vectores en los exámenes? Aquí tienes una regla visual de alto rendimiento:

🦟 Anopheles → Paludismo
🦟 Aedes → "CAZa el Dengue" (Chikungunya, Amarilla, Zika, Dengue)
🦟 Culex → Encefalitis
🪰 Flebótomo → Leishmaniasis
#MedEd #Infectología #MIR

[ZagasYum @zagasyum18]

@ainhoazabaleta5 @elmundoes ¿Por qué no emplea entonces esos términos?

Los comentarios más hirientes sobre el físico de otras mujeres los suelen pronunciar otras mujeres. En público o en privado

[ZagasYum @zagasyum18]

@NEJM Surgery

[Radiology Masterclass @RadMasterclass]

CT BRAIN QUIZ: (Pre + post contrast): What does the scan show?
A: Subdural collection
B: Multiple metastases
C: Territorial infarct
D: Enhancing mass
E: Intracerebral haemorrhage
Start Quiz https://t.co/WjdsaB2Acb

[PROMIR @PROMIR_esp]

✅ Resolvemos la pregunta comentada del #MIR

🫀 Descubre por qué la ecocardiografía transesofágica es clave para valorar la válvula mitral, detectar trombos y diagnosticar endocarditis, entre otras aplicaciones.

#examenMIR #MIR2027 #Cardiología

[ZagasYum @zagasyum18]

@montano66 El odio a Madrid tiene ya una larga historia de al menos un siglo
Nos lo enseñó @TrapielloAndres en su gran libro sobre la ciudad

¡Viva la chulería madrileña en su sentido original de ciullo! (extrovertido, jovial e infantil)

[ZagasYum @zagasyum18]

@umbertoleon ¿Qué es la inteligencia?

En juegos mentales como el ajedrez o el go, hace ya tiempo que las máquinas nos dan sopas con ondas

Resuelven mejor los problenas
Por lo que son más inteligentes

[ZagasYum @zagasyum18]

https://t.co/FlbWv9nR5A

Haydn

[Auteur House @auteurhouse]

David Lynch on finding beauty in imperfection.

[Dr David Vernon @DrDavidVernon]

A few years ago I quit my academic career because I wanted to write different kinds of books, on the music and literature I love. It was a bit of a gamble, but seems to have paid off. Sometimes, you really do just have to follow your dreams.

[Charles Herbaux @Charles_Herbaux]

🧱 This Jenga tower explains how venetoclax kills cancer cells.

In Jenga, each player pulls a block. The tower holds. Then one player pulls THE one block too many — and everything collapses.

Your cells work the exact same way. Every cell in your body carries a built-in self-destruct program: apoptosis. This program is ready to fire at any moment. What stops it? Protein-blocks holding the tower up. Here's the game:

🔸 The tower = mitochondrial potential
The mitochondrial membrane maintains a tension, an electrical potential. As long as the tower stands, the cell lives. If the tower collapses — if the potential collapses — cytochrome c escapes, caspases activate, and the cell dies. Irreversibly.

🔸 The stabilizing blocks = anti-apoptotic proteins (BCL-2, MCL-1, BCL-XL)
These proteins sit on the mitochondria like Jenga blocks. They restrain the killer proteins (BAX, BAK) and keep the tower from falling. More blocks, more stable tower. Less vulnerable cell.

🔸 The blocks being pulled = BH3-only proteins (BIM, BAD, NOXA, PUMA)
With every stress — DNA damage, survival signal deprivation, chemotherapy — the cell produces these small BH3-only proteins that neutralize a stabilizing block. One by one, blocks are removed. The tower starts to wobble.

🔸 Venetoclax = the player who pulls the BCL-2 block
Venetoclax is a specific BCL-2 inhibitor. It doesn't touch MCL-1. It doesn't touch BCL-XL. It targets one single block — and pulls it out.
If the tower was mainly held up by BCL-2 → it collapses → the cell dies. This is CLL, where BCL-2 is often THE load-bearing block.
If the tower was held up by MCL-1 → pulling BCL-2 changes nothing → the cell resists. This is one mechanism of venetoclax resistance in AML and some lymphomas.

And this is where it gets exciting.

BH3 profiling is a functional assay that measures, BEFORE treatment, how wobbly the tower already is — and above all, WHICH block is holding it up.
→ Very unstable tower ("primed" cell) = high BCL-2 dependence = venetoclax will work
→ Solid tower, stabilized by MCL-1 = a different strategy is needed

We're no longer just looking at mutations. We're testing the physics of the tower. Playing Jenga in vitro before playing it on the patient.

Next time you see a Jenga tower wobble, think of your mitochondria. They're playing the same game. All the time.

#venetoclax #apoptosis #BCL2 #BH3profiling #CLL #leukemia #hematology #oncology #MedTwitter

[Julio Mayol @juliomayol]

Interested in #AI4SurgicalTraining?

- Artificial intelligence in surgical training and education: a narrative review
- Inteligencia artificial en la formación y el entrenamiento quirúrgico: revisión narrativa

https://t.co/Bngj3yNFSk

@SurgGPT
@me4_so
@IIS_IdISSC

[DylanRevisited @DylanRevisited]

Bob Dylan World Cup Last 16

Where the personal meets the political...

Click to pick your favourite.

The one with the most votes will advance to the quarter-finals.

#BobDylanWorldCup

[ZagasYum @zagasyum18]

@DarinaMarty Algunos se sorprenden luego de la desafección de los jóvenes por la política

[Mauricio Ambriz @AmbrizMau]

Hiperoxaluria primaria.

NEJM 2022; DOI: 10.1056/NEJMicm2113369

[ZagasYum @zagasyum18]

@acertijosymas Teresa

[Philosophy Matters @PhilosophyMttrs]

How social interactions work for philosophers